Fig. 3From: Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role modelWorking hypothesis of the hierarchical cytokine network in patients with RA. White boxes indicate cells. Light gray box indicates autoantibody. Dark gray boxes indicate targeted treatments and methotrexate (MTX). RF, rheumatoid factor; AMPA, anti-modified protein antibody; SL, sublining in synovial tissues; LL, lining in synovial tissues. *Not approved in JapanBack to article page