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Fig. 7 | Inflammation and Regeneration

Fig. 7

From: Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

Fig. 7

Pharmacologically inhibiting the PDGF-BB/PDGFRβ signaling pathway reduces fibrotic scarring and fibroblasts after SCI. a Representative immunofluorescence images of GFAP (green) and PDGFRβ (red) in mice treated with imatinib or PBS (control) at 14 and 28 days post-injury (dpi). b Representative immunofluorescence images of PDGFRβ (green) and extracellular matrix fibronectin (red, upper panel) and laminin (red, lower panel) at 28 dpi. c, d Quantification of fibrotic scar area (c) and extracellular matrix area (d) in a and b. e, f Representative immunofluorescence images of PDGFRβ (green) and FSP1 (red) in mice treated as described above at 14 dpi (e) and 28 dpi (f). The nuclei are stained with DAPI (blue). High magnification images of the dotted area in the left panel are shown in the right panel. All images are from sagittal sections. g Quantification of the fibroblast area occupied by FSP1 in e and f. Scale bars: 100 μm (a, b and left panel in e and f) and 20 μm (right panel in e and f). Data are expressed as mean ± s.e.m. n = 4–6 per group. **p < 0.01 and ***p < 0.001 versus control by unpaired two-tailed Student’s t test in c, d, and g

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