Fig. 9From: Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injuryMicrovascular endothelial cells secrete PDGF-BB to induce PDGFRβ+ pericyte detachment from the blood vessel wall and then transition into fibroblasts, which contributes to the formation of fibrotic scar. The pharmacologic PDGFRβ inhibitor imatinib restrains pericyte-fibroblast transition and fibrotic scar formationBack to article page