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Fig. 9 | Inflammation and Regeneration

Fig. 9

From: Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury

Fig. 9

Microvascular endothelial cells secrete PDGF-BB to induce PDGFRβ+ pericyte detachment from the blood vessel wall and then transition into fibroblasts, which contributes to the formation of fibrotic scar. The pharmacologic PDGFRβ inhibitor imatinib restrains pericyte-fibroblast transition and fibrotic scar formation

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