Fig. 7

Electron micrograph of the spinal cord sections demonstrating a control group with intact dense compact myelin sheath (arrow) (× 20,000). b, c EB-treated group b exhibiting areas of demyelination and axonal swelling (star), degenerated mitochondria with complete loss of cristae (black arrow). Moreover, the splitting of myelin lamellae giving an onion-like appearance with shrunken atrophied axons is obvious (yellow arrow) (× 10,000). c Some nerve fibers reveal thin (arrow) interrupted (chevron) myelin sheaths (× 10,000). d, e PRP co-treated group d displaying reconstructed structure with regular more compact and thicker myelin sheaths (arrow) (× 15,000) and e Showing oligodendrocyte with euchromatic nucleus (N) and high capacity of remyelination (arrow) (× 10,000)