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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration

Fig. 2

Cellular diversity of skeletal muscle identified by single-cell RNA sequencing. Single-cell RNA sequencing analysis has revealed the detailed cellular composition of adult skeletal muscle and the molecular signature of each mononuclear cell type. This method has not only confirmed the previously established marker-based cell populations (MuSCs, FAPs, immune cells, ECs, pericytes, and neurons) but has also begun identifying new populations of tenocytes and rare cell subpopulations. Further functional analysis will reveal how each of these populations regulates skeletal muscle regeneration, leading to a better understanding of the pathophysiology of sarcopenia and fibrosis caused by regeneration defects. NMJ: neuromuscular junction; MTJ: myotendinous junction; SMMC: Smooth muscle-mesenchymal cell. Created with BioRender.com

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