Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries

Table 1 Par2 modulation experiments conducted in the same tissue assigned according to the observed phenotype. Note that in the cases in which the damage is mediated by the immune system, Par2 has an aggravating role, while in the cases in which the damage is inflicted directly to the tissue, Par2 activation alleviates the damage

System	PAR2 as a phenotypic Alleviator/acts primarily in the tissue	PAR2 as a phenotypic aggravator/ acts primarily in the immune system	Reference
Respiratory	Dissected sub-mucosal glands secrete mucus to alleviate injury		[62. ]
		Naive T cells respond to the allergen papain through PAR2, to produce IL-4 and other chemokines.	[63. ]
Colitis and inflammatory bowel diseases	protective effects of PAR2 agonists on HCl/ethanol-induced gastric mucosal injury in WT mice		[8. ]
		Mediates the pro-inflammatory effects of TxA from C. difficile.	[64. ]
Neurological disorders	PAR2KO increases the acute ischemic cerebral injury		[65. ]
		PAR2 modulates neuroinflammation and T cell proliferation during experimental autoimmune encephalomyelitis	[66. ]
Pancreatitis	Ameliorates caerulein-induced pancreatitis		[37. , 67. ]
		Exerts a worsening effect in a bile salts induced pancreatitis	[44. ]

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