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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Association of cellular immunity with severity of COVID-19 from the perspective of antigen-specific memory T cell responses and cross-reactivity

Fig. 2

Different roles of specific and cross-reactive T cells in the immune response to SARS-CoV-2 infection. When an optimal epitope with high activation potential is identified, cross-reactive T cells proliferate rapidly and robustly in a short period of time, resulting in a strong anti-viral response. In case of specific, non-cross-reactive T cells against SARS-CoV-2, T cell activation requires dendritic cells for priming, which takes time (approximately 1–2 weeks for activation and over a month for memory T cell induction)

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