Fig. 1
From: Efficacy and risk of mRNA vaccination in patients with autoimmune inflammatory rheumatic diseases
Commonalities between AIRD and COVID-19. Both AIRDs, which develop from genetic background and environmental factors, and COVID-19, which results from SARS-CoV-2 infection, are known to cause cytokine storms. In common, they are treated with glucocorticoid, JAKi, or IL-6. Among JAKis, baricitinib has also been reported to inhibit endocytosis pathway and may inhibit viral replication. COVID-19 coronavirus disease, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2, IL-6 interleukin-6, IFN interferon, TNF tumor necrosis factor, JAK Janus kinase