Fig. 1

Changes of Aβ accumulation in the brains of App^NL-G-F mice with induced colon inflammation. A Schematic diagram of inducing acute DSS colitis, chronic DSS colitis, and food allergies. B Body weight of colitis-induced App^{NL-G-F F} mice. In acute colitis model, DSS treatment was started on day 20, indicated by the red arrow. C, D Images (C) and length (D) of colons from App^NL-G-F mice on day 27. E, F Immunohistochemical staining of glial cell activation and Aβ plaques. Representative images of Aβ, GFAP, and Iba1. Scale bar = 100 μm (E). The number of Aβ plaques per mm² in cortex (F). Data points are individual mice from one representative experiment. P values were determined by one-way ANOVA (D, F). Data are shown as the mean ± s.e.m