Table 1 Fluorescent-labeled mice for intravital imaging of immune cells in the intestine
From: Intravital imaging of immune responses in intestinal inflammation
Target gene/promotor | Fluorescence | Labeled cells | Disease model | Observed phenomena | Reference |
|---|---|---|---|---|---|
LysM | eGFP | Neutrophils | Intestinal ischemia–reperfusion Celiac disease | Cell recruitment/extravasation Cell recruitment/accumulation | Hashimoto et al. [5] Lammers et al. [17] |
CCR2 | RFP | CCR2 + monocytes | DSS colitis | Changes of cellular phenotype | Honda et al. [18] |
CX3CR1 | GFP | CX3CR1 + monocytes/macrophages | DSS colitis Salmonella infection | Changes of cellular phenotype Phagocytic function | Honda et al. [18] Niess et al. [19] |
CX3CR1 × CD11c | GFP × YFP | Dendritic cells | Salmonella infection | Phagocytic function | Farache et al. [20] |
TCRδ | eGFP | TCRδ + intraepithelial lymphocytes | Indomethacin/LPS-induced intestinal leakage | Changes in cell movement Intercellular contacts | Sumida et al. [21] Hu et al. [22] |
Foxp3 | tdTomato | Regulatory T cells | Intestinal inflammation | Changes in cell movement | Sujino et al. [23] |
CD2 × IL13 | GFP × tdTomato | Group 2 innate lymphoid cells | Helminth infection | Intercellular contacts | Lok et al. [24] |
Rorc × IL22 | GFP × tdTomato | Group 3 innate lymphoid cells | Intestinal inflammation | Changes in cell movement | Jarade et al. [25] |
Eo | tdTomato, GFP | Eosinophils | Helminth infection | Cell recruitment/accumulation | Nguyen et al. [26] |