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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

Fig. 1

Infiltration of activated CD8+ T cells increased in the injured spinal cords. A Representative flow cytometry images showing the percentage of CD8+ T cells (CD3+CD4−CD8+) at 0, 3, 7, 14, and 35 dpi after SCI, n = 6 independent mice. B and C Statistical box plots of A, *P < 0.05, ***P < 0.001, ****P < 0.0001, one-way ANOVA with Tukey. D Immunofluorescence images of a sagittal section showing the location of CD8+ T cells (red) after SCI at 14 dpi. CD31 (green) is used to label endothelial cells of blood vessels. The lesion border was outlined by a dashed white line. V, ventral; D, dorsal; R, rostral; C, caudal. Scale bar, 500 μm or 50 μm. E–G Flow cytometry images showing the expression levels of CD69, CTLA-4, and PD-1 in CD8+ T cells in sham blood, 14 dpi, and 35 dpi groups, respectively. n = 5 independent mice. **P < 0.01, ****P < 0.0001, one-way ANOVA with Tukey. MFI, mean fluorescence intensity

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Inflammation and Regeneration

ISSN: 1880-8190

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