Fig. 5
From: A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis
Structure simulation of mouse Alb-CTLA4Ig. The protein sequences of mAlb-CTLA4Ig were input into the online server ROBETTA for structure prediction. Shown here are the front view and the side view (rotated 90°) of the predicted structure of the fusion protein where albumin is represented in green, the extracellular domain of mouse CTLA4 is represented in magenta, the mouse Ig domain is represented in white, and the MMP substrate sequence is represented in red. Note that the CDR3-like loop is blocked by helix h4 (light blue) of domain IIb and helix h3 (orange) of domain IIIb