Fig. 8

Dexamethasone and TEMPOL reduced IL-1α-induced effects in 7W mice. A Experimental steps. B Representative photos of mice on the 14th day after dexamethasone treatment. Blue arrows direct the PBS area, and red arrows direct the IL-1α area. C IL-1α failed to increase the outer hair length under the treatment of dexamethasone (PBS vs IL-1α, 1.796 ± 0.5952 vs 1.775 ± 0.5914, n = 10). D Representative pictures of HE and Sirius Red staining from the same mouse. E IL-1α did not increase HFs size (PBS vs IL-1α, 0.4420 ± 0.04205 vs 0.5618 ± 0.04586, n = 10). F IL-1α increased skin thickness (PBS vs IL-1α, 2.272 ± 0.07921 vs 2.625 ± 0.09812, n = 10). G Representative pictures from Lgr5 + /mTmG mice. H Experimental steps. I TEMPOL delayed IL-1α-induced hair regrowth. *P < 0.05, **P < 0.01