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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

Fig. 1

JAK inhibitor suppressed the function of inflammation-activated mature osteoclasts. A Representative intravital multiphoton imaging results of the bone resorptive activity of mature osteoclasts in calvarial bones in JAK inhibitor (JAKi)-treated LPS-induced mice. Green, pHocas-3; red, TRAP-tdTomato+ mature osteoclasts; blue, bones (second harmonic generation). Arrowheads: bone resorption areas. Scale bar, 30 µm. B The bone resorption index (BRI) of mature osteoclasts. A higher BRI indicates increased osteoclast activity (steady state, n = 43 images; vehicle, n = 40 images; JAKi, n = 38 images from 5 mice per group). Error bars indicate the means + SDs. C Mobility of mature osteoclasts. A higher cell deformation index (CDI) indicates increased mobility (steady state, n = 32 cells from 3 mice; vehicle, n = 36 cells from 3 mice; JAKi, n = 30 cells from 4 mice). Error bars indicate the means ± SDs. Statistical significance was determined by Kruskal-Wallis test. **P < 0.01, ***P < 0.001 ****P<0.0001

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