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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

Fig. 4

Scheme of the effects of JAK inhibitor on osteoclasts in vivo. Under inflammatory conditions, many osteoclast precursors migrate to the bone surface at the inflammatory site through CCR1-induced signaling. These cells differentiate into mature osteoclasts and cause abnormal bone destruction (left). JAK inhibitor decreased the expression of Ccr1 on osteoclast precursors and blocked the migration of these cells to the bone surface, resulting in a decrease in the number of mature osteoclasts. In addition, JAK inhibitor suppressed the bone resorptive activity of mature osteoclasts (right)

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Inflammation and Regeneration

ISSN: 1880-8190

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