Fig. 2
From: Group 2 innate lymphoid cells and their surrounding environment
Regulation of ILC2s by epithelial cells. ILC2s reside just below the epithelial cells in mucosal tissues, such as lung, intestine and skin. IL-33, IL-25, and TSLP are released from epithelial cell in response to epithelial damage due to invasion of allergen, helminth and pathogen. These alarmins activate ILC2s and lead to type 2 inflammation