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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: The Ragulator complex: delving its multifunctional impact on metabolism and beyond

Fig. 2

Schematic model of mTORC1 and AMPK regulation by the Ragulator complex. When nutrients are abundant, active v-ATPase stimulates the GEF activity of Ragulator toward Rags and activates mTORC1. Active mTORC1 switches on anabolic pathways. Upon glucose starvation, inactive v-ATPase and the Ragulator complex become accessible for AXIN binding, which in turn inhibits the GEF activity of the Ragulator complex, leading to the dissociation of mTORC1 from lysosomes. Starvation leads to the translocation of AXIN/LKB1 to lysosomes, where LKB1 phosphorylates and activates AMPK, switching on catabolism

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