The official journal of the Japanese Society of Inflammation and Regeneration.
Articles
Page 2 of 6
-
Citation: Inflammation and Regeneration 2022 42:41
-
Localization and movement of Tregs in gastrointestinal tract: a systematic review
The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that prevents systemic autoimmune diseases and inhibits inflammation by encount...
Citation: Inflammation and Regeneration 2022 42:47 -
IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis
Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the r...
Citation: Inflammation and Regeneration 2022 42:46 -
Therapy-resistant nature of cancer stem cells in view of iron metabolism
Due to increased resistance to standard chemo/radiotherapies and relapse, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for the development of effective cancer treatments...
Citation: Inflammation and Regeneration 2022 42:34 -
Mesenchymal stromal cells in the thymus
The microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site fo...
Citation: Inflammation and Regeneration 2022 42:33 -
Characterization of the human gut virome in metabolic and autoimmune diseases
The intestinal microbiome is dominated by bacteria and plays a pivotal role in the occurrence and development of disease, including several metabolic and autoimmune disorders. While intestinal viral communitie...
Citation: Inflammation and Regeneration 2022 42:32 -
A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats
Multiple sclerosis (MS) is a progressive autoimmune demyelinating disease of the central nervous system. To date, there is no effective therapy for it. Our study aimed to determine the potential role of platel...
Citation: Inflammation and Regeneration 2022 42:45 -
Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment
Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable ...
Citation: Inflammation and Regeneration 2022 42:40 -
Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges
Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. Characterized by the loss of learning, memory, problem-solving, language, and other thinking abilit...
Citation: Inflammation and Regeneration 2022 42:31 -
Morphology-based noninvasive early prediction of serial-passage potency enhances the selection of clone-derived high-potency cell bank from mesenchymal stem cells
Rapidly expanding clones (RECs) are one of the single-cell-derived mesenchymal stem cell clones sorted from human bone marrow mononuclear cells (BMMCs), which possess advantageous features. The RECs exhibit lo...
Citation: Inflammation and Regeneration 2022 42:30 -
Identification of molecular subtypes based on inflammatory response in lower-grade glioma
Inflammatory response is an important characteristic affecting prognosis and therapeutic response in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory response are still under exp...
Citation: Inflammation and Regeneration 2022 42:29 -
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in p...
Citation: Inflammation and Regeneration 2022 42:44 -
Enhancer RNA commits osteogenesis via microRNA-3129 expression in human bone marrow-derived mesenchymal stem cells
Highly regulated gene expression program underlies osteogenesis of mesenchymal stem cells (MSCs), but the regulators in the program are not entirely identified. As enhancer RNAs (eRNAs) have recently emerged a...
Citation: Inflammation and Regeneration 2022 42:43 -
Entering the era of precision medicine through multiomics approach
Citation: Inflammation and Regeneration 2022 42:42 -
Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease
Helicobacter pylori (HP) is a Gram-negative bacterium that colonizes the human stomach chronically. Colonization of HP in the gastric mucosa not only causes gastrointestinal diseases, but also is associated with ...
Citation: Inflammation and Regeneration 2022 42:39 -
Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and me...
Citation: Inflammation and Regeneration 2022 42:38 -
Thymic self-antigen expression for immune tolerance and surveillance
T cells are a group of lymphocytes that play a central role in the immune system, notably, eliminating pathogens and attacking cancer while being tolerant of the self. Elucidating how immune tolerance is ensur...
Citation: Inflammation and Regeneration 2022 42:28 -
Osteoclast biology in the single-cell era
Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasi...
Citation: Inflammation and Regeneration 2022 42:27 -
Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases
The skin serves as the interface between the human body and the environment and interacts with the microbial community. The skin microbiota consists of microorganisms, such as bacteria, fungi, mites, and virus...
Citation: Inflammation and Regeneration 2022 42:26 -
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extrace...
Citation: Inflammation and Regeneration 2022 42:25 -
Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells
Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP...
Citation: Inflammation and Regeneration 2022 42:24 -
Extracellular vesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease that occurs due to increased fibrosis of lung tissue in response to chronic injury of the epithelium. Therapeutic options for IPF remain limite...
Citation: Inflammation and Regeneration 2022 42:23 -
Inflammation-associated premetastatic niche formation
Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory “seed-and-soil.” Both cancer cell-intrinsic properties (“seed”) and fertile microenvironment ...
Citation: Inflammation and Regeneration 2022 42:22 -
Clinical perspectives and therapeutic strategies: pediatric autoinflammatory disease—a multi-faceted approach to fever of unknown origin of childhood
Among the different etiologies for fever of unknown origin in children, infectious diseases are the most frequent final diagnosis, followed by autoimmune diseases and malignancies. Autoinflammatory diseases ar...
Citation: Inflammation and Regeneration 2022 42:21 -
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia
Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particula...
Citation: Inflammation and Regeneration 2022 42:20 -
Marine-derived microbes and molecules for drug discovery
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and c...
Citation: Inflammation and Regeneration 2022 42:18 -
Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion
Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts. An advanced intravital imaging system using a two-photon...
Citation: Inflammation and Regeneration 2022 42:17 -
Duration of SARS-CoV-2 RNA positivity from various specimens and clinical characteristics in patients with COVID-19: a systematic review and meta-analysis
The duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA positivity will be important to prevent the spread of coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis...
Citation: Inflammation and Regeneration 2022 42:16 -
Neuroplasticity related to chronic pain and its modulation by microglia
Neuropathic pain is often chronic and can persist after overt tissue damage heals, suggesting that its underlying mechanism involves the alteration of neuronal function. Such an alteration can be a direct cons...
Citation: Inflammation and Regeneration 2022 42:15 -
The superficial zone of articular cartilage
The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signal...
Citation: Inflammation and Regeneration 2022 42:14 -
Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue is the origin of chronic inflammation of metabolic syndrome...
Citation: Inflammation and Regeneration 2022 42:13 -
Immune-instructive copolymer scaffolds using plant-derived nanoparticles to promote bone regeneration
Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly patients.
Citation: Inflammation and Regeneration 2022 42:12 -
The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has long been considered to suppress ...
Citation: Inflammation and Regeneration 2022 42:11 -
A case of refractory systemic lupus erythematosus with monocytosis exhibiting somatic KRAS mutation
Systemic lupus erythematosus (SLE), an autoimmune disorder that damages various organ systems, is caused by a combination of genetic and environmental factors. Although germline mutations of several genes are ...
Citation: Inflammation and Regeneration 2022 42:10 -
Editorial: Towards a better understanding of the physiology of the lymphatics
Citation: Inflammation and Regeneration 2022 42:19 -
Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination
Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in...
Citation: Inflammation and Regeneration 2022 42:7 -
Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus
The expression of FZD5 distinguishes immature human mesenchymal stem/stromal cells (MSC) in cultures, and the function of FZD5 is crucial for maintaining the proliferation and multilineage differentiation capacit...
Citation: Inflammation and Regeneration 2022 42:6 -
Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
Endothelial–mesenchymal transition (EndoMT), a cellular differentiation process in which endothelial cells (ECs) lose their properties and differentiate into mesenchymal cells, has been observed not only durin...
Citation: Inflammation and Regeneration 2022 42:9 -
Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model
Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens. To suppress allo-immune respons...
Citation: Inflammation and Regeneration 2022 42:4 -
A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice
ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO...
Citation: Inflammation and Regeneration 2022 42:3 -
Morphological heterogeneity description enabled early and parallel non-invasive prediction of T-cell proliferation inhibitory potency and growth rate for facilitating donor selection of human mesenchymal stem cells
Within the extensively developed therapeutic application of mesenchymal stem cells (MSCs), allogenic immunomodulatory therapy is among the promising categories. Although donor selection is a critical early pro...
Citation: Inflammation and Regeneration 2022 42:8 -
Axon guidance molecules in immunometabolic diseases
The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of t...
Citation: Inflammation and Regeneration 2022 42:5 -
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Studies analyzing heterochronic parabiosis mice models showed that molecules in the blood of young mice rejuvenate aged mice. Therefore, blood-based therapies have become one of the therapeutic approaches to b...
Citation: Inflammation and Regeneration 2022 42:2 -
Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1
Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investi...
Citation: Inflammation and Regeneration 2022 42:1 -
Endothelial-specific depletion of TGF-β signaling affects lymphatic function
Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel...
Citation: Inflammation and Regeneration 2021 41:35 -
Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS ...
Citation: Inflammation and Regeneration 2021 41:34 -
Isolation and characterization of neural stem/progenitor cells in the subventricular zone of the naked mole-rat brain
The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan of more than 37 years and shows a negligible senescence phenotype, suggesting that tissue stem cells of NMRs are highly capable of m...
Citation: Inflammation and Regeneration 2021 41:31 -
Molecular biology of autoinflammatory diseases
The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of vario...
Citation: Inflammation and Regeneration 2021 41:33 -
A short review on lymphatic endothelial cell heterogeneity
Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in ...
Citation: Inflammation and Regeneration 2021 41:32 -
Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disorders
Autophagy is a highly conserved mechanism of delivering cytoplasmic components for lysosomal degradation. Among the three major autophagic pathways, chaperone-mediated autophagy (CMA) is primarily characterize...
Citation: Inflammation and Regeneration 2021 41:29
Follow
Annual Journal Metrics
-
Citation Impact
10.426 - 2-Year Impact Factor (2021)
8.388 - 5-Year Impact Factor (2021)
1.423 - Source Normalized Impact per Paper (SNIP)
1.962 - Scimago Journal Rank (SJR)Speed
13 days to first decision for all manuscripts (Median)
34 days to first decision for reviewed manuscripts only (Median)Usage
347,031 Downloads (2022)
332 Altmetric mentions (2021)