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  1. Review

    Organ dysfunction as a new standard for defining sepsis

    Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...

    Seitaro Fujishima

    Inflammation and Regeneration 2016 36:24

    Published on: 15 November 2016

  2. Review

    Liver regeneration and fibrosis after inflammation

    The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the...

    Minoru Tanaka and Atsushi Miyajima

    Inflammation and Regeneration 2016 36:19

    Published on: 18 October 2016

  3. Review

    Age-related sarcopenia and its pathophysiological bases

    Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, includin...

    Sumito Ogawa, Mitsutaka Yakabe and Masahiro Akishita

    Inflammation and Regeneration 2016 36:17

    Published on: 7 September 2016

  4. Review

    Inflammatory predisposition predicts disease phenotypes in muscular dystrophy

    Duchenne muscular dystrophy is an incurable genetic disease that presents with skeletal muscle weakness and chronic inflammation and is associated with early mortality. Indeed, immune cell infiltration into th...

    Yuko Nitahara-Kasahara, Shin’ichi Takeda and Takashi Okada

    Inflammation and Regeneration 2016 36:14

    Published on: 5 September 2016

  5. Research article

    Mycobacterium avium infection induces the resistance of the interferon-γ response in mouse spleen cells at late stages of infection

    Bacterial infections cause an increase in the population of hematopoietic stem cells (HSCs). To investigate the downstream factors associated with hematopoietic stem cells, mice are infected with Mycobacterium av...

    Atsuko Masumi, Keiko Mochida, Kazuya Takizawa, Takuo Mizukami, Madoka Kuramitsu, Momoka Tsuruhara, Shigetarou Mori, Keigo Shibayama, Kazunari Yamaguchi and Isao Hamaguchi

    Inflammation and Regeneration 2016 36:21

    Published on: 26 August 2016

  6. Review

    The pathological role of vascular aging in cardio-metabolic disorder

    Chronological aging is linked to cellular senescence, and there is accumulating evidence for a pathological role of cellular senescence in age-related disorders such as obesity, diabetes, and heart failure. Th...

    Goro Katsuumi, Ippei Shimizu, Yohko Yoshida and Tohru Minamino

    Inflammation and Regeneration 2016 36:16

    Published on: 16 August 2016

  7. Review

    Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes

    The renin-angiotensin system (RAS) regulates diverse cellular responses and is crucial for normal organ development and function. On the other hand, RAS exerts deleterious effects promoting cardiovascular and ...

    Takehiro Kamo, Hiroshi Akazawa, Jun-ichi Suzuki and Issei Komuro

    Inflammation and Regeneration 2016 36:12

    Published on: 9 August 2016

  8. Review

    RANKL system in vascular and valve calcification with aging

    Vascular and cardiac valve calcification is associated with cardiovascular mortality in the general population. Increasing clinical and experimental evidence suggests that inflammation accelerates the progress...

    Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori, Masakazu Kohno and Ryuichi Morishita

    Inflammation and Regeneration 2016 36:10

    Published on: 1 August 2016

  9. Review

    BAFF- and APRIL-targeted therapy in systemic autoimmune diseases

    B cells play a pivotal role in autoimmunity not only by producing pathogenic autoantibodies but also by modulating immune responses via the production of cytokines and chemokines. The B cell-activating factor/...

    Shingo Nakayamada and Yoshiya Tanaka

    Inflammation and Regeneration 2016 36:6

    Published on: 21 July 2016

  10. Review

    GM-CSF as a therapeutic target in autoimmune diseases

    Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been known as a hematopoietic growth factor and immune modulator. Recent studies revealed that GM-CSF also had pro-inflammatory functions and contr...

    Aoi Shiomi, Takashi Usui and Tsuneyo Mimori

    Inflammation and Regeneration 2016 36:8

    Published on: 5 July 2016

  11. Review

    Dysfunctional immunoproteasomes in autoinflammatory diseases

    Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding fo...

    Hideki Arimochi, Yuki Sasaki, Akiko Kitamura and Koji Yasutomo

    Inflammation and Regeneration 2016 36:13

    Published on: 28 May 2016

  12. Review

    Metabolic regulation by secreted phospholipase A2

    Within the phospholipase A2 (PLA2) superfamily that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 isoforms in ...

    Hiroyasu Sato, Yoshitaka Taketomi and Makoto Murakami

    Inflammation and Regeneration 2016 36:7

    Published on: 21 May 2016

  13. Review

    Usefulness of nailfold videocapillaroscopy for systemic sclerosis

    Systemic sclerosis is a complex disease that involves “autoimmunity,” “inflammation,” “fibrosis,” and “vasculopathy.” Microvascular damage and dysfunction particularly represent the earliest morphological and ...

    Satoshi Kubo and Yoshiya Tanaka

    Inflammation and Regeneration 2016 36:5

    Published on: 25 April 2016

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