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Table 2 Application of different FGFs in non-critical-sized bone defect in vivo models

From: Role of fibroblast growth factors in bone regeneration

Growth factor Dose In vivo model Carrier Investigations Effect References
FGF2 200 μg Monkey ulna fracture Injectable gelatin hydrogel Bone mineral content and mechanical properties Accelerates fracture healing and prevents nonunion [67]
FGF2 2.5 μg Rat periodontal defect (2 × 2 × 1.7 mm) Injectable calcium phosphate cement Histology and histomorphometry of bone Increased periodontal regeneration [68]
FGF2 50 μg Rat calvarial defect (4-mm diameter) PLGA/β-TCP Histomorphometry of bone Enhanced bone regeneration [69]
FGF2 50 μg/ml Rat calvarial defect (5-mm diameter) Collagen and nano-bioactive glass hybrid membrane Histomorphometry of bone Accelerated bone regeneration [70]
FGF2 45 μg Rabbit femoral condyle (4-mm diameter and 6 mm long) Hydrogel polymer Bone mass and microarchitecture Enhanced bone regeneration [32]
FGF2 10 μg Rat tibia (2-mm diameter, 4 mm long) Titanium implant Bone histomorphometry Synergistically enhanced new bone formation [71]
Melatonin 100 mg/kg i.p.
FGF2 200, 400, or 800 μg Human tibia (high tibial osteotomy) Gelatin hydrogel Radiographic assessment of bone Dose dependently accelerated bone union [72]
FGF2 100 μg Rabbit femoral condyle (10 mm2 × 5 mm depth) Interconnected porous calcium hydroxyapatite ceramic Bone histomorphometry Decreases lamellar bone formation, increases vascularization and osseointegration [73]
FGF2 0, 25, or 250 ng Rat calvarial defect (3.5-mm diameter) PLGA/gelatin Radiological, histological, and biochemical examination Low-dose administration enhanced the degree of calcification and ALP activity [74]
BMP2 0.1 mg/ml
FGF9 2 μg Mouse tibia (1-mm defect) Collagen sponge Bone histomorphometry Enhances angiogenesis and bone regeneration [19]
  1. The table shows the various growth factors and their combinations used for regeneration of non-critical-sized defects, their dose, the site of application, the carrier used for the application, and the investigations through which the effects of bone healing have been studied
  2. i.p. intraperitoneal injection
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Inflammation and Regeneration

ISSN: 1880-8190

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