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  1. Content type: Review

    Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic i...

    Authors: Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo, Tomomi Ichikawa and Toshinori Nakayama

    Citation: Inflammation and Regeneration 2018 38:10

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  2. Content type: Review

    Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic approach for geriatric disorders. The molecular mechanisms underlying age-related dysfunctions of specific types of a...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Hirotaka Kito, Aoi Matsubara, Mizuki Kaneda, Yu Katsuyama and Hayato Naka-Kaneda

    Citation: Inflammation and Regeneration 2018 38:9

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  3. Content type: Review

    Periodontal diseases are chronic infectious disease in which the pathogenic bacteria initiate the host immune response leading to the destruction of tooth supporting tissue and eventually result in the tooth l...

    Authors: Gurjeet Kaur, Vishakha Grover, Nandini Bhaskar, Rose Kanwaljeet Kaur and Ashish Jain

    Citation: Inflammation and Regeneration 2018 38:8

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  4. Content type: Review

    Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is ...

    Authors: Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka and Shuichi Matsuda

    Citation: Inflammation and Regeneration 2018 38:7

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  5. Content type: Review

    Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland...

    Authors: Naoto Azuma, Yoshinori Katada and Hajime Sano

    Citation: Inflammation and Regeneration 2018 38:6

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  6. Content type: Review

    The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maint...

    Authors: Ryu Okumura and Kiyoshi Takeda

    Citation: Inflammation and Regeneration 2018 38:5

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  7. Content type: Case report

    Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blocka...

    Authors: Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2018 38:3

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  8. Content type: Research article

    MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyos...

    Authors: Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura and Iwao Sekigawa

    Citation: Inflammation and Regeneration 2018 38:1

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  9. Content type: Research article

    We previously reported that the mouse Ly6/Plaur domain containing 8 (mLypd8), a GPI-anchored protein highly and selectively expressed on colonic epithelia, contributes to segregation of intestinal microbiota a...

    Authors: Chiao-Ching Hsu, Ryu Okumura and Kiyoshi Takeda

    Citation: Inflammation and Regeneration 2017 37:23

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  10. Content type: Research article

    Abatacept, a CTLA4-Ig fusion protein attenuates T cell activation by inhibiting the CD80/86-CD28 costimulatory pathway that is required for the proper T cell activation and thus displays beneficial effects in ...

    Authors: Toshihiro Tono, Satoko Aihara, Takayuki Hoshiyama, Yoshiyuki Arinuma, Tatsuo Nagai and Shunsei Hirohata

    Citation: Inflammation and Regeneration 2017 37:24

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  11. Content type: Research article

    We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However...

    Authors: Miki Maehara, Masato Sato, Eriko Toyoda, Takumi Takahashi, Eri Okada, Tomomi Kotoku and Masahiko Watanabe

    Citation: Inflammation and Regeneration 2017 37:22

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  12. Content type: Review

    We recently developed novel cell transplantation method “cell transfer technology” utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patter...

    Authors: Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi and Ikuo Morita

    Citation: Inflammation and Regeneration 2017 37:21

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  13. Content type: Research article

    In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MS...

    Authors: Aya Fujishiro, Yasuo Miura, Masaki Iwasa, Sumie Fujii, Noriko Sugino, Akira Andoh, Hideyo Hirai, Taira Maekawa and Tatsuo Ichinohe

    Citation: Inflammation and Regeneration 2017 37:19

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  14. Content type: Review

    Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...

    Authors: Pornkawee Charoenlarp, Arun Kumar Rajendran and Sachiko Iseki

    Citation: Inflammation and Regeneration 2017 37:10

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  15. Content type: Review

    Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...

    Authors: Hironori Hara, Norifumi Takeda and Issei Komuro

    Citation: Inflammation and Regeneration 2017 37:13

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  16. Content type: Review

    Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...

    Authors: Sachiko Ono, Gyohei Egawa and Kenji Kabashima

    Citation: Inflammation and Regeneration 2017 37:11

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  17. Content type: Review

    Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...

    Authors: Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata and Shuji Terai

    Citation: Inflammation and Regeneration 2017 37:16

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