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  1. Metastasis remains the leading cause of cancer-related death. In 1889, Stephen Paget originally proposed the theory “seed-and-soil.” Both cancer cell-intrinsic properties (“seed”) and fertile microenvironment ...

    Authors: Atsuko Deguchi and Yoshiro Maru
    Citation: Inflammation and Regeneration 2022 42:22
  2. Among the different etiologies for fever of unknown origin in children, infectious diseases are the most frequent final diagnosis, followed by autoimmune diseases and malignancies. Autoinflammatory diseases ar...

    Authors: Akihiro Yachie
    Citation: Inflammation and Regeneration 2022 42:21
  3. Microglia are innate immune cells that are the only residential macrophages in the central nervous system. They play vital physiological roles in the adult brain and during development. Microglia are particula...

    Authors: Iki Sonn, Fumiko Honda-Ozaki, Sho Yoshimatsu, Satoru Morimoto, Hirotaka Watanabe and Hideyuki Okano
    Citation: Inflammation and Regeneration 2022 42:20
  4. Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and c...

    Authors: Yoshimasa Tanaka, Megumi Nishikawa, Kaho Kamisaki, Saki Hachiya, Moeka Nakamura, Takahiro Kuwazuru, Susumu Tanimura, Kiyoshi Soyano and Kohsuke Takeda
    Citation: Inflammation and Regeneration 2022 42:18
  5. Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts. An advanced intravital imaging system using a two-photon...

    Authors: Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta and Masaru Ishii
    Citation: Inflammation and Regeneration 2022 42:17
  6. The duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA positivity will be important to prevent the spread of coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis...

    Authors: Yasutaka Okita, Takayoshi Morita and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2022 42:16
  7. Neuropathic pain is often chronic and can persist after overt tissue damage heals, suggesting that its underlying mechanism involves the alteration of neuronal function. Such an alteration can be a direct cons...

    Authors: Shin-ichiro Hiraga, Takahide Itokazu, Mariko Nishibe and Toshihide Yamashita
    Citation: Inflammation and Regeneration 2022 42:15
  8. The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel effects of PRG4 as a signal...

    Authors: Taku Saito
    Citation: Inflammation and Regeneration 2022 42:14
  9. Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue is the origin of chronic inflammation of metabolic syndrome...

    Authors: Rumi Hachiya, Miyako Tanaka, Michiko Itoh and Takayoshi Suganami
    Citation: Inflammation and Regeneration 2022 42:13
  10. Age-driven immune signals cause a state of chronic low-grade inflammation and in consequence affect bone healing and cause challenges for clinicians when repairing critical-sized bone defects in elderly patients.

    Authors: Salwa Suliman, Anna Mieszkowska, Justyna Folkert, Neha Rana, Samih Mohamed-Ahmed, Tiziana Fuoco, Anna Finne-Wistrand, Kai Dirscherl, Bodil Jørgensen, Kamal Mustafa and Katarzyna Gurzawska-Comis
    Citation: Inflammation and Regeneration 2022 42:12
  11. Systemic lupus erythematosus (SLE), an autoimmune disorder that damages various organ systems, is caused by a combination of genetic and environmental factors. Although germline mutations of several genes are ...

    Authors: Sze-Ming Law, Shuji Akizuki, Akio Morinobu and Koichiro Ohmura
    Citation: Inflammation and Regeneration 2022 42:10
  12. Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous system (CNS) injuries and diseases. However, the roles of these cells and the molecular mechanisms toward regeneration in...

    Authors: Lili Quan, Akiko Uyeda and Rieko Muramatsu
    Citation: Inflammation and Regeneration 2022 42:7
  13. The expression of FZD5 distinguishes immature human mesenchymal stem/stromal cells (MSC) in cultures, and the function of FZD5 is crucial for maintaining the proliferation and multilineage differentiation capacit...

    Authors: Satoru Miyagi, Yuko Kato, Ayako Watanabe, Kenichi Miyamoto, Rintaro Yoshikawa, Keita Hagiya, Daisuke Hirano and Yumi Matsuzaki
    Citation: Inflammation and Regeneration 2022 42:6
  14. Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens. To suppress allo-immune respons...

    Authors: Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2022 42:4
  15. ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO...

    Authors: Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa and Shuji Terai
    Citation: Inflammation and Regeneration 2022 42:3
  16. Within the extensively developed therapeutic application of mesenchymal stem cells (MSCs), allogenic immunomodulatory therapy is among the promising categories. Although donor selection is a critical early pro...

    Authors: Yuta Imai, Kei Kanie and Ryuji Kato
    Citation: Inflammation and Regeneration 2022 42:8
  17. The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of t...

    Authors: Yoshimitsu Nakanishi, Sujin Kang and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2022 42:5
  18. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investi...

    Authors: Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato and Takafumi Ichikawa
    Citation: Inflammation and Regeneration 2022 42:1
  19. Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel...

    Authors: Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe and Fumiko Itoh
    Citation: Inflammation and Regeneration 2021 41:35
  20. Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS ...

    Authors: Kenichi Serizawa, Haruna Tomizawa-Shinohara, Shota Miyake, Kenji Yogo and Yoshihiro Matsumoto
    Citation: Inflammation and Regeneration 2021 41:34
  21. The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan of more than 37 years and shows a negligible senescence phenotype, suggesting that tissue stem cells of NMRs are highly capable of m...

    Authors: Yuki Yamamura, Yoshimi Kawamura, Yuki Oiwa, Kaori Oka, Nobuyuki Onishi, Hideyuki Saya and Kyoko Miura
    Citation: Inflammation and Regeneration 2021 41:31
  22. The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of vario...

    Authors: Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata and Naoe Kaneko
    Citation: Inflammation and Regeneration 2021 41:33
  23. Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in ...

    Authors: Masayuki Miyasaka
    Citation: Inflammation and Regeneration 2021 41:32
  24. The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated ...

    Authors: Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li…
    Citation: Inflammation and Regeneration 2021 41:28
  25. The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-...

    Authors: Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe and Suguru Takeuchi
    Citation: Inflammation and Regeneration 2021 41:27
  26. The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vas...

    Authors: Ryota Hokari and Akira Tomioka
    Citation: Inflammation and Regeneration 2021 41:25
  27. Even within a single type of cancer, cells of various types exist and play interrelated roles. Each of the individual cells resides in a distinct microenvironment and behaves differently. Such heterogeneity is...

    Authors: Satoi Nagasawa, Yukie Kashima, Ayako Suzuki and Yutaka Suzuki
    Citation: Inflammation and Regeneration 2021 41:22
  28. Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel...

    Authors: Kentaro Iwata, Yohei Mikami, Motohiko Kato, Naohisa Yahagi and Takanori Kanai
    Citation: Inflammation and Regeneration 2021 41:21
  29. Advances in DNA sequencing technology have significantly impacted human genetics; they have enabled the analysis of genetic causes of rare diseases, which are usually pathogenic variants in a single gene at th...

    Authors: Yusuke Kawashima, Ryuta Nishikomori and Osamu Ohara
    Citation: Inflammation and Regeneration 2021 41:19
  30. Systemic sclerosis (SSc) is a complex disease, in which an interaction of genetic and environmental factors plays an important role in its development and pathogenesis. A number of genetic studies, including c...

    Authors: Yuko Ota and Masataka Kuwana
    Citation: Inflammation and Regeneration 2021 41:17
  31. Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...

    Authors: Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono and Yoshiya Ito
    Citation: Inflammation and Regeneration 2021 41:16
  32. Silicone tube (ST) conduits have been accepted as a therapeutic alternative to direct nerve suturing in the treatment of nerve injuries; however, the search for optimal adjuncts to maximize the outcomes is sti...

    Authors: Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari and Alireza Shams
    Citation: Inflammation and Regeneration 2021 41:13
  33. Extracellular vesicles (EVs) are known to be secreted by various cells. In particular, mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have tissue repair capacity and anti-inflammatory properties. Dental pul...

    Authors: Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara and Jun Takebe
    Citation: Inflammation and Regeneration 2021 41:12
  34. The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and...

    Authors: Masahiro Nakano, Yukiko Iwasaki and Keishi Fujio
    Citation: Inflammation and Regeneration 2021 41:11


The official journal of the Japanese Society of Inflammation and Regeneration.

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