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  1. Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...

    Authors: Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono and Yoshiya Ito

    Citation: Inflammation and Regeneration 2021 41:16

    Content type: Review

    Published on:

  2. Silicone tube (ST) conduits have been accepted as a therapeutic alternative to direct nerve suturing in the treatment of nerve injuries; however, the search for optimal adjuncts to maximize the outcomes is sti...

    Authors: Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari and Alireza Shams

    Citation: Inflammation and Regeneration 2021 41:13

    Content type: Research article

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  3. Extracellular vesicles (EVs) are known to be secreted by various cells. In particular, mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have tissue repair capacity and anti-inflammatory properties. Dental pul...

    Authors: Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara and Jun Takebe

    Citation: Inflammation and Regeneration 2021 41:12

    Content type: Research article

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  4. The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and...

    Authors: Masahiro Nakano, Yukiko Iwasaki and Keishi Fujio

    Citation: Inflammation and Regeneration 2021 41:11

    Content type: Review

    Published on:

  5. To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...

    Authors: Yuya Shirai and Yukinori Okada

    Citation: Inflammation and Regeneration 2021 41:6

    Content type: Review

    Published on:

  6. Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and re...

    Authors: Azela Glady, Arno Vandebroek and Masato Yasui

    Citation: Inflammation and Regeneration 2021 41:4

    Content type: Research article

    Published on:

  7. Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...

    Authors: Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita and Keiichi Fukuda

    Citation: Inflammation and Regeneration 2021 41:5

    Content type: Review

    Published on:

  8. The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be genetic, but secondary to rapidly modernized environmen...

    Authors: Yusuke Yoshimatsu, Yohei Mikami and Takanori Kanai

    Citation: Inflammation and Regeneration 2021 41:3

    Content type: Review

    Published on:

  9. Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiat...

    Authors: Erinn Zixuan Sim, Nobuaki Shiraki and Shoen Kume

    Citation: Inflammation and Regeneration 2021 41:1

    Content type: Review

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  10. Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of t...

    Authors: Kento Otani and Takashi Shichita

    Citation: Inflammation and Regeneration 2020 40:28

    Content type: Review

    Published on:

  11. Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunte...

    Authors: Sou Nakamura, Naoshi Sugimoto and Koji Eto

    Citation: Inflammation and Regeneration 2020 40:30

    Content type: Review

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  12. The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are s...

    Authors: Arun Kumar Rajendan, Yoshinori Arisaka, Nobuhiko Yui and Sachiko Iseki

    Citation: Inflammation and Regeneration 2020 40:27

    Content type: Review

    Published on:

  13. Bone homeostasis is dynamically regulated by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Visualizing and evaluating the dynamics of bone cells in vivo remain difficult u...

    Authors: Kunihiko Hashimoto, Takashi Kaito, Junichi Kikuta and Masaru Ishii

    Citation: Inflammation and Regeneration 2020 40:26

    Content type: Review

    Published on:

  14. Spinal cord injury (SCI) is a devastating event that causes permanent neurologic impairments. Cell transplantation therapy using neural precursor cells (NPCs) is a promising intervention aiming to replace dama...

    Authors: Narihito Nagoshi, Hideyuki Okano and Masaya Nakamura

    Citation: Inflammation and Regeneration 2020 40:40

    Content type: Review

    Published on:

  15. Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been ...

    Authors: Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi, Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2020 40:25

    Content type: Research article

    Published on:

  16. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread globally to most countries. In Japan, the first COVID-...

    Authors: Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe and Hirotaka Kanuka

    Citation: Inflammation and Regeneration 2020 40:38

    Content type: Review

    Published on:

  17. In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world d...

    Authors: Misato Hashizume

    Citation: Inflammation and Regeneration 2020 40:24

    Content type: Review

    Published on:

  18. The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some...

    Authors: Shintaro Hojyo, Mona Uchida, Kumiko Tanaka, Rie Hasebe, Yuki Tanaka, Masaaki Murakami and Toshio Hirano

    Citation: Inflammation and Regeneration 2020 40:37

    Content type: Review

    Published on:

  19. Hair follicle (HF) formation and growth are sustained by epithelial-mesenchymal interaction via growth factors and cytokines. Pivotal roles of FGFs on HF regeneration and neogenesis have been reported mainly i...

    Authors: Misaki Kinoshita-Ise, Aki Tsukashima, Tomonari Kinoshita, Yoshimi Yamazaki and Manabu Ohyama

    Citation: Inflammation and Regeneration 2020 40:35

    Content type: Research article

    Published on:

  20. In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are ...

    Authors: Kiyotaka Okada, Minoru Nishioka and Hiroshi Kaji

    Citation: Inflammation and Regeneration 2020 40:22

    Content type: Review

    Published on:

  21. The COVID-19 pandemic highlighted the vulnerability of every aspect of the globalized world, including R&D. Potentially critical R&D areas have been neglected because of the lack of market-driven incentives. H...

    Authors: Hiroki Nakatani, Kei Katsuno and Hayato Urabe

    Citation: Inflammation and Regeneration 2020 40:34

    Content type: Review

    Published on:

  22. Due to the nature of enhanced resistance to conventional chemo/radiotherapies and metastasis, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for cancer eradication. To tac...

    Authors: Tetsuya Taga and Kouichi Tabu

    Citation: Inflammation and Regeneration 2020 40:33

    Content type: Review

    Published on:

  23. It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mech...

    Authors: Yoshitaka Kase and Hideyuki Okano

    Citation: Inflammation and Regeneration 2020 40:32

    Content type: Rapid communication

    Published on:

  24. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinica...

    Authors: Yoshiya Tanaka

    Citation: Inflammation and Regeneration 2020 40:20

    Content type: Review

    Published on:

  25. Analysis of various genetically modified mice, with supernumerary teeth, has revealed the following two intrinsic molecular mechanisms that increase the number of teeth. One plausible explanation for supernume...

    Authors: Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata and Kazuhisa Bessho

    Citation: Inflammation and Regeneration 2020 40:21

    Content type: Review

    Published on:

  26. Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative ...

    Authors: So Nakagawa and Takayuki Miyazawa

    Citation: Inflammation and Regeneration 2020 40:17

    Content type: Review

    Published on:

    The Correction to this article has been published in Inflammation and Regeneration 2020 40:41

  27. An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating pandemic. As we have not developed curative medicine and effective vaccine, the end of this life-threatening infectious disease is...

    Authors: Ryo Otsuka and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2020 40:19

    Content type: Review

    Published on:

  28. Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.

    Authors: Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka and Masaru Ishii

    Citation: Inflammation and Regeneration 2020 40:15

    Content type: Research article

    Published on:

  29. The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura…

    Citation: Inflammation and Regeneration 2020 40:14

    Content type: Review

    Published on:

  30. Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...

    Authors: Yoshitaka Kase, Takuya Shimazaki and Hideyuki Okano

    Citation: Inflammation and Regeneration 2020 40:10

    Content type: Review

    Published on:

  31. Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...

    Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada and Teruhisa Kawamura

    Citation: Inflammation and Regeneration 2020 40:8

    Content type: Review

    Published on:


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