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  1. The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of t...

    Authors: Yoshimitsu Nakanishi, Sujin Kang and Atsushi Kumanogoh

    Citation: Inflammation and Regeneration 2022 42:5

    Content type: Review

    Published on:

  2. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investi...

    Authors: Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato and Takafumi Ichikawa

    Citation: Inflammation and Regeneration 2022 42:1

    Content type: Research article

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  3. Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel...

    Authors: Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe and Fumiko Itoh

    Citation: Inflammation and Regeneration 2021 41:35

    Content type: Research article

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  4. Neuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). MS ...

    Authors: Kenichi Serizawa, Haruna Tomizawa-Shinohara, Shota Miyake, Kenji Yogo and Yoshihiro Matsumoto

    Citation: Inflammation and Regeneration 2021 41:34

    Content type: Review

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  5. The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan of more than 37 years and shows a negligible senescence phenotype, suggesting that tissue stem cells of NMRs are highly capable of m...

    Authors: Yuki Yamamura, Yoshimi Kawamura, Yuki Oiwa, Kaori Oka, Nobuyuki Onishi, Hideyuki Saya and Kyoko Miura

    Citation: Inflammation and Regeneration 2021 41:31

    Content type: Research article

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  6. The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of vario...

    Authors: Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata and Naoe Kaneko

    Citation: Inflammation and Regeneration 2021 41:33

    Content type: Review

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  7. Recent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in ...

    Authors: Masayuki Miyasaka

    Citation: Inflammation and Regeneration 2021 41:32

    Content type: Review

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  8. The liver has a high regenerative ability and can induce spontaneous regression of fibrosis when early liver damage occurs; however, these abilities are lost when chronic liver damage results in decompensated ...

    Authors: Shunsuke Nojiri, Atsunori Tsuchiya, Kazuki Natsui, Suguru Takeuchi, Takayuki Watanabe, Yuichi Kojima, Yusuke Watanabe, Hiroteru Kamimura, Masahiro Ogawa, Satoko Motegi, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Yui Ishii, Tomomi Kitayama, Yu-Tung Li…

    Citation: Inflammation and Regeneration 2021 41:28

    Content type: Research article

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  9. The liver is a highly regenerative organ; however, its regeneration potential is reduced by chronic inflammation with fibrosis accumulation, leading to cirrhosis. With an aim to tackle liver cirrhosis, a life-...

    Authors: Shuji Terai, Atsunori Tsuchiya, Yusuke Watanabe and Suguru Takeuchi

    Citation: Inflammation and Regeneration 2021 41:27

    Content type: Review

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  10. The lymphatic vasculature returns filtered interstitial arterial fluid and tissue metabolites to the blood circulation. It also plays a major role in lipid absorption and immune cell trafficking. Lymphatic vas...

    Authors: Ryota Hokari and Akira Tomioka

    Citation: Inflammation and Regeneration 2021 41:25

    Content type: Review

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  11. Even within a single type of cancer, cells of various types exist and play interrelated roles. Each of the individual cells resides in a distinct microenvironment and behaves differently. Such heterogeneity is...

    Authors: Satoi Nagasawa, Yukie Kashima, Ayako Suzuki and Yutaka Suzuki

    Citation: Inflammation and Regeneration 2021 41:22

    Content type: Review

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  12. Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel...

    Authors: Kentaro Iwata, Yohei Mikami, Motohiko Kato, Naohisa Yahagi and Takanori Kanai

    Citation: Inflammation and Regeneration 2021 41:21

    Content type: Review

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  13. Advances in DNA sequencing technology have significantly impacted human genetics; they have enabled the analysis of genetic causes of rare diseases, which are usually pathogenic variants in a single gene at th...

    Authors: Yusuke Kawashima, Ryuta Nishikomori and Osamu Ohara

    Citation: Inflammation and Regeneration 2021 41:19

    Content type: Review

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  14. Systemic sclerosis (SSc) is a complex disease, in which an interaction of genetic and environmental factors plays an important role in its development and pathogenesis. A number of genetic studies, including c...

    Authors: Yuko Ota and Masataka Kuwana

    Citation: Inflammation and Regeneration 2021 41:17

    Content type: Review

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  15. Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3. Idiopathic pulm...

    Authors: Hideki Amano, Yoshio Matsui, Ko Hatanaka, Kanako Hosono and Yoshiya Ito

    Citation: Inflammation and Regeneration 2021 41:16

    Content type: Review

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  16. Silicone tube (ST) conduits have been accepted as a therapeutic alternative to direct nerve suturing in the treatment of nerve injuries; however, the search for optimal adjuncts to maximize the outcomes is sti...

    Authors: Sepehr Aghajanian, Aliasghar Taghi Doulabi, Masoume Akhbari and Alireza Shams

    Citation: Inflammation and Regeneration 2021 41:13

    Content type: Research article

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  17. Extracellular vesicles (EVs) are known to be secreted by various cells. In particular, mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have tissue repair capacity and anti-inflammatory properties. Dental pul...

    Authors: Yuka Imanishi, Masaki Hata, Ryohei Matsukawa, Atsushi Aoyagi, Maiko Omi, Makoto Mizutani, Keiko Naruse, Shogo Ozawa, Masaki Honda, Tatsuaki Matsubara and Jun Takebe

    Citation: Inflammation and Regeneration 2021 41:12

    Content type: Research article

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  18. The management of systemic lupus erythematosus (SLE) remains challenging for clinicians because of the clinical heterogeneity of this disease. In attempts to identify useful biomarkers for the diagnosis of and...

    Authors: Masahiro Nakano, Yukiko Iwasaki and Keishi Fujio

    Citation: Inflammation and Regeneration 2021 41:11

    Content type: Review

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  19. To date, genome-wide association studies (GWASs) have successfully identified thousands of associations between genetic polymorphisms and human traits. However, the pathways between the associated genotype and...

    Authors: Yuya Shirai and Yukinori Okada

    Citation: Inflammation and Regeneration 2021 41:6

    Content type: Review

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  20. Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and re...

    Authors: Azela Glady, Arno Vandebroek and Masato Yasui

    Citation: Inflammation and Regeneration 2021 41:4

    Content type: Research article

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  21. Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...

    Authors: Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita and Keiichi Fukuda

    Citation: Inflammation and Regeneration 2021 41:5

    Content type: Review

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  22. The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be genetic, but secondary to rapidly modernized environmen...

    Authors: Yusuke Yoshimatsu, Yohei Mikami and Takanori Kanai

    Citation: Inflammation and Regeneration 2021 41:3

    Content type: Review

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  23. Human pluripotent stem cells (PSCs), including human embryonic stem cells and induced pluripotent stem cells, are promising cell sources in regenerating pancreatic islets through in vitro directed differentiat...

    Authors: Erinn Zixuan Sim, Nobuaki Shiraki and Shoen Kume

    Citation: Inflammation and Regeneration 2021 41:1

    Content type: Review

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  24. The world today is facing a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which mainly causes a respiratory disease known as coronavirus disease 2019 (COVID-19). Therefore, i...

    Authors: Taichiro Minami, Yasunori Iwata and Takashi Wada

    Citation: Inflammation and Regeneration 2020 40:31

    Content type: Review

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    The Correction to this article has been published in Inflammation and Regeneration 2021 41:24

  25. Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of t...

    Authors: Kento Otani and Takashi Shichita

    Citation: Inflammation and Regeneration 2020 40:28

    Content type: Review

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  26. Platelet products are used in treatments for thrombocytopenia caused by hematopoietic diseases, chemotherapy, massive hemorrhages, extracorporeal circulation, and others. Their manufacturing depends on volunte...

    Authors: Sou Nakamura, Naoshi Sugimoto and Koji Eto

    Citation: Inflammation and Regeneration 2020 40:30

    Content type: Review

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  27. The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials’ properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are s...

    Authors: Arun Kumar Rajendan, Yoshinori Arisaka, Nobuhiko Yui and Sachiko Iseki

    Citation: Inflammation and Regeneration 2020 40:27

    Content type: Review

    Published on:

  28. Bone homeostasis is dynamically regulated by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Visualizing and evaluating the dynamics of bone cells in vivo remain difficult u...

    Authors: Kunihiko Hashimoto, Takashi Kaito, Junichi Kikuta and Masaru Ishii

    Citation: Inflammation and Regeneration 2020 40:26

    Content type: Review

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  29. Spinal cord injury (SCI) is a devastating event that causes permanent neurologic impairments. Cell transplantation therapy using neural precursor cells (NPCs) is a promising intervention aiming to replace dama...

    Authors: Narihito Nagoshi, Hideyuki Okano and Masaya Nakamura

    Citation: Inflammation and Regeneration 2020 40:40

    Content type: Review

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  30. Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been ...

    Authors: Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi, Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2020 40:25

    Content type: Research article

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  31. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread globally to most countries. In Japan, the first COVID-...

    Authors: Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe and Hirotaka Kanuka

    Citation: Inflammation and Regeneration 2020 40:38

    Content type: Review

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  32. In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world d...

    Authors: Misato Hashizume

    Citation: Inflammation and Regeneration 2020 40:24

    Content type: Review

    Published on:


The official journal of the Japanese Society of Inflammation and Regeneration.

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