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  1. In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are ...

    Authors: Kiyotaka Okada, Minoru Nishioka and Hiroshi Kaji

    Citation: Inflammation and Regeneration 2020 40:22

    Content type: Review

    Published on:

  2. The COVID-19 pandemic highlighted the vulnerability of every aspect of the globalized world, including R&D. Potentially critical R&D areas have been neglected because of the lack of market-driven incentives. H...

    Authors: Hiroki Nakatani, Kei Katsuno and Hayato Urabe

    Citation: Inflammation and Regeneration 2020 40:34

    Content type: Review

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  3. Due to the nature of enhanced resistance to conventional chemo/radiotherapies and metastasis, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for cancer eradication. To tac...

    Authors: Tetsuya Taga and Kouichi Tabu

    Citation: Inflammation and Regeneration 2020 40:33

    Content type: Review

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  4. It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mech...

    Authors: Yoshitaka Kase and Hideyuki Okano

    Citation: Inflammation and Regeneration 2020 40:32

    Content type: Rapid communication

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  5. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinica...

    Authors: Yoshiya Tanaka

    Citation: Inflammation and Regeneration 2020 40:20

    Content type: Review

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  6. Analysis of various genetically modified mice, with supernumerary teeth, has revealed the following two intrinsic molecular mechanisms that increase the number of teeth. One plausible explanation for supernume...

    Authors: Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata and Kazuhisa Bessho

    Citation: Inflammation and Regeneration 2020 40:21

    Content type: Review

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  7. An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating pandemic. As we have not developed curative medicine and effective vaccine, the end of this life-threatening infectious disease is...

    Authors: Ryo Otsuka and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2020 40:19

    Content type: Review

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  8. Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.

    Authors: Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka and Masaru Ishii

    Citation: Inflammation and Regeneration 2020 40:15

    Content type: Research article

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  9. The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura…

    Citation: Inflammation and Regeneration 2020 40:14

    Content type: Review

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  10. Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...

    Authors: Yoshitaka Kase, Takuya Shimazaki and Hideyuki Okano

    Citation: Inflammation and Regeneration 2020 40:10

    Content type: Review

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  11. Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...

    Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada and Teruhisa Kawamura

    Citation: Inflammation and Regeneration 2020 40:8

    Content type: Review

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  12. Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions i...

    Authors: Naoki Hosen

    Citation: Inflammation and Regeneration 2020 40:4

    Content type: Review

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  13. Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signalin...

    Authors: Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki and Tomoki Nakashima

    Citation: Inflammation and Regeneration 2020 40:2

    Content type: Review

    Published on:

  14. Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...

    Authors: Yoshikazu Kishino, Jun Fujita, Shugo Tohyama, Marina Okada, Sho Tanosaki, Shota Someya and Keiichi Fukuda

    Citation: Inflammation and Regeneration 2020 40:1

    Content type: Review

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  15. Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...

    Authors: Yutaka Kuroda, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda

    Citation: Inflammation and Regeneration 2019 39:20

    Content type: Review

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  16. Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its l...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Tomoaki Yoshida, Shunsuke Nojiri, Masahiro Ogawa and Shuji Terai

    Citation: Inflammation and Regeneration 2019 39:18

    Content type: Review

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  17. Induced pluripotent stem cells (iPSCs) can be produced from various somatic cells and have the ability to differentiate into various cells and tissues of the body. Regenerative medicine using iPSCs is expected...

    Authors: Masafumi Umekage, Yoshiko Sato and Naoko Takasu

    Citation: Inflammation and Regeneration 2019 39:17

    Content type: Review

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  18. Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential a...

    Authors: Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito and Takahiro Ochiya

    Citation: Inflammation and Regeneration 2019 39:13

    Content type: Review

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  19. Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 fam...

    Authors: Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa and Junya Masumoto

    Citation: Inflammation and Regeneration 2019 39:12

    Content type: Review

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  20. Chimeric antigen receptor (CAR) T cell therapy is a new cancer immunotherapy targeting cancer-specific cell surface antigen. CD19-CAR T cells have been already shown to be very effective to B cell leukemia/lym...

    Authors: Kana Hasegawa and Naoki Hosen

    Citation: Inflammation and Regeneration 2019 39:10

    Content type: Review

    Published on:

  21. During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell...

    Authors: Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi and Nobuyuki Takakura

    Citation: Inflammation and Regeneration 2019 39:9

    Content type: Research article

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  22. Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, ...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Shinsuke Ikeno, Hitomi Taniura, Masayoshi Kurono, Keito Minemori, Yu Katsuyama and Hayato Naka-Kaneda

    Citation: Inflammation and Regeneration 2019 39:8

    Content type: Research article

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  23. TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of...

    Authors: Maryam Hormozi, Mohammadreza Gholami, Ayda Babaniazi and Anneh Mohammad Gharravi

    Citation: Inflammation and Regeneration 2019 39:7

    Content type: Research article

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  24. T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are compos...

    Authors: Ryunosuke Muro, Hiroshi Takayanagi and Takeshi Nitta

    Citation: Inflammation and Regeneration 2019 39:6

    Content type: Review

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  25. Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demogra...

    Authors: Noriko Kimura, Katsuya Suzuki and Tsutomu Takeuchi

    Citation: Inflammation and Regeneration 2019 39:5

    Content type: Research article

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  26. Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, mac...

    Authors: Kentaro Maruyama, Eiji Nemoto and Satoru Yamada

    Citation: Inflammation and Regeneration 2019 39:3

    Content type: Review

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  27. Finding the best dressing for a specific wound had continued from the past to present. The aim of this study was to evaluate the effect of encapsulated extract of Satureja khuzistanica in hydrogel alginate at wou...

    Authors: Fatemeh Beyranvand, Ahmad Gharzi, Abolfazl Abbaszadeh, Reza Mohammadrezaei Khorramabadi, Mohammadreza Gholami and Anneh Mohammad Gharravi

    Citation: Inflammation and Regeneration 2019 39:2

    Content type: Research article

    Published on:

  28. Periodontopathic bacteria such as Porphyromonas gingivalis produce a large amount of butyric acid as a metabolite. Though butyric acid has been reported to have an anti-inflammatory effect on inflammatory disease...

    Authors: Michihiro Shirasugi, Maki Nakagawa, Keisuke Nishioka, Toshiro Yamamoto, Takaaki Nakaya and Narisato Kanamura

    Citation: Inflammation and Regeneration 2018 38:23

    Content type: Review

    Published on:


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