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  1. Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...

    Authors: Yutaka Kuroda, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda

    Citation: Inflammation and Regeneration 2019 39:20

    Content type: Review

    Published on:

  2. Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its l...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Tomoaki Yoshida, Shunsuke Nojiri, Masahiro Ogawa and Shuji Terai

    Citation: Inflammation and Regeneration 2019 39:18

    Content type: Review

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  3. Induced pluripotent stem cells (iPSCs) can be produced from various somatic cells and have the ability to differentiate into various cells and tissues of the body. Regenerative medicine using iPSCs is expected...

    Authors: Masafumi Umekage, Yoshiko Sato and Naoko Takasu

    Citation: Inflammation and Regeneration 2019 39:17

    Content type: Review

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  4. Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential a...

    Authors: Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito and Takahiro Ochiya

    Citation: Inflammation and Regeneration 2019 39:13

    Content type: Review

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  5. Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 fam...

    Authors: Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa and Junya Masumoto

    Citation: Inflammation and Regeneration 2019 39:12

    Content type: Review

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  6. Chimeric antigen receptor (CAR) T cell therapy is a new cancer immunotherapy targeting cancer-specific cell surface antigen. CD19-CAR T cells have been already shown to be very effective to B cell leukemia/lym...

    Authors: Kana Hasegawa and Naoki Hosen

    Citation: Inflammation and Regeneration 2019 39:10

    Content type: Review

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  7. During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell...

    Authors: Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi and Nobuyuki Takakura

    Citation: Inflammation and Regeneration 2019 39:9

    Content type: Research article

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  8. Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, ...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Shinsuke Ikeno, Hitomi Taniura, Masayoshi Kurono, Keito Minemori, Yu Katsuyama and Hayato Naka-Kaneda

    Citation: Inflammation and Regeneration 2019 39:8

    Content type: Research article

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  9. TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of...

    Authors: Maryam Hormozi, Mohammadreza Gholami, Ayda Babaniazi and Anneh Mohammad Gharravi

    Citation: Inflammation and Regeneration 2019 39:7

    Content type: Research article

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  10. T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are compos...

    Authors: Ryunosuke Muro, Hiroshi Takayanagi and Takeshi Nitta

    Citation: Inflammation and Regeneration 2019 39:6

    Content type: Review

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  11. Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demogra...

    Authors: Noriko Kimura, Katsuya Suzuki and Tsutomu Takeuchi

    Citation: Inflammation and Regeneration 2019 39:5

    Content type: Research article

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  12. Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, mac...

    Authors: Kentaro Maruyama, Eiji Nemoto and Satoru Yamada

    Citation: Inflammation and Regeneration 2019 39:3

    Content type: Review

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  13. Finding the best dressing for a specific wound had continued from the past to present. The aim of this study was to evaluate the effect of encapsulated extract of Satureja khuzistanica in hydrogel alginate at wou...

    Authors: Fatemeh Beyranvand, Ahmad Gharzi, Abolfazl Abbaszadeh, Reza Mohammadrezaei Khorramabadi, Mohammadreza Gholami and Anneh Mohammad Gharravi

    Citation: Inflammation and Regeneration 2019 39:2

    Content type: Research article

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  14. Periodontopathic bacteria such as Porphyromonas gingivalis produce a large amount of butyric acid as a metabolite. Though butyric acid has been reported to have an anti-inflammatory effect on inflammatory disease...

    Authors: Michihiro Shirasugi, Maki Nakagawa, Keisuke Nishioka, Toshiro Yamamoto, Takaaki Nakaya and Narisato Kanamura

    Citation: Inflammation and Regeneration 2018 38:23

    Content type: Review

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  15. In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a cas...

    Authors: Maho Nakazawa, Katsuya Suzuki, Hidekata Yasuoka, Kunihiro Yamaoka and Tsutomu Takeuchi

    Citation: Inflammation and Regeneration 2018 38:20

    Content type: Case report

    Published on:

  16. Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibril...

    Authors: Ayaka Nakanishi, Naoe Kaneko, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Wei Zhou, Mie Kurata, Toshihiro Yamamoto, Sheikh Mohammad Fazle Akbar, Tamotsu Zako and Junya Masumoto

    Citation: Inflammation and Regeneration 2018 38:27

    Content type: Research article

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  17. In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA seq...

    Authors: Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio and Kazuhiko Yamamoto

    Citation: Inflammation and Regeneration 2018 38:21

    Content type: Review

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  18. Mitochondria regulate not only cell functions through energy generation but also aging-associated cell phenotypes. Impaired mitochondrial structural and functional integrity accompanied by excessive mitochondr...

    Authors: Kazuya Tsubouchi, Jun Araya and Kazuyoshi Kuwano

    Citation: Inflammation and Regeneration 2018 38:18

    Content type: Review

    Published on:

  19. Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injure...

    Authors: Hidetoshi Masumoto and Jun K. Yamashita

    Citation: Inflammation and Regeneration 2018 38:26

    Content type: Review

    Published on:

  20. Morphological change in endothelial cells is an initial and crucial step in the process of establishing a functional vascular network. Following or associated with differentiation and proliferation, endothelia...

    Authors: Kiyomi Tsuji-Tamura and Minetaro Ogawa

    Citation: Inflammation and Regeneration 2018 38:25

    Content type: Review

    Published on:

  21. Atherosclerosis and inflammation are more common in patients with diabetes than in patients without diabetes, and atherosclerosis progression contributes to inflammation. Therefore, anti-inflammatory therapy i...

    Authors: Shiho Yamadera, Yuya Nakamura, Masahiro Inagaki, Sachiyo Kenmotsu, Tetsuhito Nohara, Naoki Sato, Tatsunori Oguchi, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Akihiko Yura, Yuji Kiuchi and Shinichi Iwai

    Citation: Inflammation and Regeneration 2018 38:13

    Content type: Research article

    Published on:

  22. Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli and lead to kidney fibrosis. Connective tissue g...

    Authors: Naohiro Toda, Masashi Mukoyama, Motoko Yanagita and Hideki Yokoi

    Citation: Inflammation and Regeneration 2018 38:14

    Content type: Review

    Published on:

  23. Cysts of the salivary glands are common lesions that occur in the context of various etiologies. Although the diagnostic importance of cysts in salivary gland diseases has been well studied, molecular mechanis...

    Authors: Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2018 38:12

    Content type: Case report

    Published on:

  24. Zoledronic acid (Zol), one of the bisphosphonates, is frequently utilized for the treatment of osteoporosis and bone metastasis. However, the onset of medication-related osteonecrosis of the jaw (MRONJ) follow...

    Authors: Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga and Tatsuji Nishihara

    Citation: Inflammation and Regeneration 2018 38:16

    Content type: Research article

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  25. Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic i...

    Authors: Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo, Tomomi Ichikawa and Toshinori Nakayama

    Citation: Inflammation and Regeneration 2018 38:10

    Content type: Review

    Published on:

  26. Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic approach for geriatric disorders. The molecular mechanisms underlying age-related dysfunctions of specific types of a...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Hirotaka Kito, Aoi Matsubara, Mizuki Kaneda, Yu Katsuyama and Hayato Naka-Kaneda

    Citation: Inflammation and Regeneration 2018 38:9

    Content type: Review

    Published on:

  27. Periodontal diseases are chronic infectious disease in which the pathogenic bacteria initiate the host immune response leading to the destruction of tooth supporting tissue and eventually result in the tooth l...

    Authors: Gurjeet Kaur, Vishakha Grover, Nandini Bhaskar, Rose Kanwaljeet Kaur and Ashish Jain

    Citation: Inflammation and Regeneration 2018 38:8

    Content type: Review

    Published on:

  28. Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is ...

    Authors: Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka and Shuichi Matsuda

    Citation: Inflammation and Regeneration 2018 38:7

    Content type: Review

    Published on:

  29. Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland...

    Authors: Naoto Azuma, Yoshinori Katada and Hajime Sano

    Citation: Inflammation and Regeneration 2018 38:6

    Content type: Review

    Published on:

  30. The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maint...

    Authors: Ryu Okumura and Kiyoshi Takeda

    Citation: Inflammation and Regeneration 2018 38:5

    Content type: Review

    Published on:

  31. Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blocka...

    Authors: Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2018 38:3

    Content type: Case report

    Published on:


The official journal of the Japanese Society of Inflammation and Regeneration.

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