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  1. Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant to anti-cancer drugs and a deeper unders...

    Authors: Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2023 43:46
    Content type: Research article Published on:

  2. Idiopathic pulmonary fibrosis (IPF) is a progressive aging-related lung disease with a poor prognosis. Despite extensive research, the cause of IPF remains largely unknown and treatment strategies are limited....

    Authors: Ryusuke Kizawa, Jun Araya and Yu Fujita
    Citation: Inflammation and Regeneration 2023 43:45
    Content type: Review Published on:

  3. The types of bone damage in rheumatoid arthritis (RA) include joint erosion, periarticular osteoporosis, and systemic osteoporosis. Janus kinase (JAK) inhibitors ameliorate inflammation and joint erosion in RA...

    Authors: Masatsugu Komagamine, Noriko Komatsu, Rui Ling, Kazuo Okamoto, Shi Tianshu, Kotaro Matsuda, Tsutomu Takeuchi, Yuko Kaneko and Hiroshi Takayanagi
    Citation: Inflammation and Regeneration 2023 43:44
    Content type: Research article Published on:

  4. Disease-specific induced pluripotent stem cells (iPSCs) are useful tools for pathological analysis and diagnosis of rare diseases. Given the limited available resources, banking such disease-derived iPSCs and ...

    Authors: Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi and Shinya Yamanaka
    Citation: Inflammation and Regeneration 2023 43:43
    Content type: Research article Published on:

  5. Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to su...

    Authors: Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Chia-Chen Ku, Jia-Bin Pan, Ya-Han Yang, Shigeo Saito, Chun-Chieh Wu, Ying-Chu Lin, Kuang-Hung Cheng, Kung-Kai Kuo, Michiya Noguchi, Yukio Nakamura, Tohru Yoshioka, Deng-Chyang Wu, Chang-Shen Lin…
    Citation: Inflammation and Regeneration 2023 43:42
    Content type: Research article Published on:

  6. During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aor...

    Authors: Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama and Tetsuya Taga
    Citation: Inflammation and Regeneration 2023 43:41
    Content type: Research article Published on:

  8. Recently accumulating evidence identified the disease entity where astrocytes residing within the central nervous system (CNS) are the target of autoantibody-mediated autoimmunity. Aquaporin4 (AQP4) is the mos...

    Authors: Makoto Kinoshita and Tatsusada Okuno
    Citation: Inflammation and Regeneration 2023 43:39
    Content type: Review Published on:

  9. Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic me...

    Authors: Shota Yamamoto and Takahiro Masuda
    Citation: Inflammation and Regeneration 2023 43:38
    Content type: Review Published on:

  10. Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injur...

    Authors: Tian Lan, Yang Tai, Chong Zhao, Yang Xiao, Zhu Yang, Linhao Zhang, Can Gan, Wenting Dai, Huan Tong, Chengwei Tang, Zhiyin Huang and Jinhang Gao
    Citation: Inflammation and Regeneration 2023 43:37
    Content type: Research article Published on:

  11. Impaired wound re-epithelialization contributes to cutaneous barrier reconstruction dysfunction. Recently, N6-methyladenosine (m6A) RNA modification has been shown to participate in the determination of RNA fate,...

    Authors: Xin Huang, Yixuan Zhao, Daiming Liu, Shuchen Gu, Yunhan Liu, Yimin Khoong, Shenying Luo, Zewei Zhang, Wenzheng Xia, Meng Wang, Hsin Liang, Minxiong Li, Qingfeng Li and Tao Zan
    Citation: Inflammation and Regeneration 2023 43:36
    Content type: Research article Published on:

  12. This study aimed to investigate how aging alters the homeostasis of the colonic intestinal epithelium and regeneration after tissue injury using organoid models and to identify its underlying molecular mechanism.

    Authors: Min Kyoung Jo, Chang Mo Moon, Hyeon-Jeong Jeon, Yerim Han, Eun Sook Lee, Ji-Hee Kwon, Kyung-Min Yang, Young-Ho Ahn, Seong-Eun Kim, Sung-Ae Jung and Tae Il Kim
    Citation: Inflammation and Regeneration 2023 43:35
    Content type: Research article Published on:

  15. Bone defects remain a challenge today. In addition to osteogenic activation, the crucial role of angiogenesis has also gained attention. In particular, vascular endothelial growth factor (VEGF) is likely to pl...

    Authors: Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Jia Deng, Noriyuki Wakabayashi and Keiji Itaka
    Citation: Inflammation and Regeneration 2023 43:32
    Content type: Research article Published on:

  16. In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing evidence has shown that the external ...

    Authors: Zi-Yuan Zhang, Zhao-Yang Zuo, Yang Liang, Si-Ming Zhang, Chun-Xia Zhang, Jing Chi, Bin Fan and Guang-Yu Li
    Citation: Inflammation and Regeneration 2023 43:31
    Content type: Research article Published on:

  18. Aging of the global population increases the incidence of osteoporosis and associated fragility fractures, significantly impacting patient quality of life and healthcare costs. The acute inflammatory reaction ...

    Authors: Junichi Kushioka, Simon Kwoon-Ho Chow, Masakazu Toya, Masanori Tsubosaka, Huaishuang Shen, Qi Gao, Xueping Li, Ning Zhang and Stuart B. Goodman
    Citation: Inflammation and Regeneration 2023 43:29
    Content type: Review Published on:

  20. Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d. iNKT cells express an invariant T cell receptor (...

    Authors: Takahiro Aoki, Shinichiro Motohashi and Haruhiko Koseki
    Citation: Inflammation and Regeneration 2023 43:27
    Content type: Review Published on:

  22. Authors: Cassandra Margotta, Paola Fabbrizio, Marco Ceccanti, Chiara Cambieri, Gabriele Rufolo, Jessica D’Agostino, Maria Chiara Trolese, Pierangelo Cifelli, Veronica Alfano, Christian Laurini, Silvia Scaricamazza, Alberto Ferri, Gianni Sorarù, Eleonora Palma, Maurizio Inghilleri, Caterina Bendotti…
    Citation: Inflammation and Regeneration 2023 43:25
    Content type: Correction Published on:

    The original article was published in Inflammation and Regeneration 2023 43:19

  23. Human mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV) revealed neuroprotective potentials in various brain injury models, including neonatal encephalopathy caused by hypoxia–ischemia (HI). H...

    Authors: Nicole Labusek, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Tobias Tertel, Constanze Wiek, Helmut Hanenberg, Peter A. Horn, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel and Josephine Herz
    Citation: Inflammation and Regeneration 2023 43:24
    Content type: Research article Published on:

  24. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an inherited cerebral small vessel disease (CSVD) caused by biallelic mutations in the high-temperature req...

    Authors: Emi Qian, Masahiro Uemura, Hiroya Kobayashi, Shiho Nakamura, Fumiko Ozawa, Sho Yoshimatsu, Mitsuru Ishikawa, Osamu Onodera, Satoru Morimoto and Hideyuki Okano
    Citation: Inflammation and Regeneration 2023 43:23
    Content type: Rapid communication Published on:

  25. Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative a...

    Authors: Pengxiang Zhao, Zheng Dang, Mengyu Liu, Dazhi Guo, Ruiliu Luo, Mingzi Zhang, Fei Xie, Xujuan Zhang, Youbin Wang, Shuyi Pan and Xuemei Ma
    Citation: Inflammation and Regeneration 2023 43:22
    Content type: Research article Published on:

  26. Since the discovery of group 2 innate lymphoid cells (ILC2s) in 2010, subsequent studies have revealed their developmental pathways, mechanisms of activation and regulation, and immunological roles in tissue h...

    Authors: Maiko Naito and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2023 43:21
    Content type: Review Published on:

  27. Alzheimer’s disease (AD) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (Aβ) aggregates and phosphorylated tau with aging. The aggregation of Aβ, whi...

    Authors: Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C. Saido and Minako Ito
    Citation: Inflammation and Regeneration 2023 43:20
    Content type: Research article Published on:

  28. Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease in terms of onset and progression rate. This may account for therapeutic clinical trial failure. Transgenic SOD1G93A mice on C57 or 129Sv backgrou...

    Authors: Cassandra Margotta, Paola Fabbrizio, Marco Ceccanti, Chiara Cambieri, Gabriele Ruffolo, Jessica D’Agostino, Maria Chiara Trolese, Pierangelo Cifelli, Veronica Alfano, Christian Laurini, Silvia Scaricamazza, Alberto Ferri, Gianni Sorarù, Eleonora Palma, Maurizio Inghilleri, Caterina Bendotti…
    Citation: Inflammation and Regeneration 2023 43:19
    Content type: Research article Published on:

    The Correction to this article has been published in Inflammation and Regeneration 2023 43:25

  29. Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JA...

    Authors: Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi and Masaru Ishii
    Citation: Inflammation and Regeneration 2023 43:18
    Content type: Research article Published on:

  30. Extracellular vesicles (EVs) are nano-sized lipid-bilayer encapsulated vesicles produced by the cells. These EVs are released into the surrounding space by almost all cell types. The EVs help in intercellular ...

    Authors: Tasaduq Manzoor, Afnan Saleem, Nida Farooq, Lateef Ahmad Dar, Junaid Nazir, Sahar Saleem, Sameena Ismail, Mudasir Bashir Gugjoo, Parvaiz A. Shiekh and Syed Mudasir Ahmad
    Citation: Inflammation and Regeneration 2023 43:17
    Content type: Review Published on:

  33. The hair follicles (HFs) are barely regenerated after loss in injuries in mammals as well as in human beings. Recent studies have shown that the regenerative ability of HFs is age-related; however, the relatio...

    Authors: Guang Yang, Haiyan Chen, Qun Chen, Jiayi Qiu, Mulan Qahar, Zhimeng Fan, Weiwei Chu, Edward E. Tredget and Yaojiong Wu
    Citation: Inflammation and Regeneration 2023 43:14
    Content type: Research article Published on:

  34. CTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of human IgG1 that is approved for treating rheumatoid arthritis. However, CTLA4...

    Authors: Fu-Yao Jiang, Yan-Zhu Zhang, Yuan-Hong Tai, Chien-Yu Chou, Yu-Ching Hsieh, Ya-Chi Chang, Hsiao-Chen Huang, Zhi-Qin Li, Yuan-Chin Hsieh, I-Ju Chen, Bo-Cheng Huang, Yu-Cheng Su, Wen-Wei Lin, Hsin-Chieh Lin, Jui-I Chao, Shyng-Shiou F. Yuan…
    Citation: Inflammation and Regeneration 2023 43:13
    Content type: Research article Published on:

  35. Spinal cord injury (SCI) causes nearly all patients to suffer from protracted disabilities. An emerging therapeutic strategy involving the recruitment of endogenous neural stem cells (NSCs) has been developed....

    Authors: Jingyu Wang, Lintao Xu, Deqing Peng, Yongjian Zhu, Zhaowen Gu, Ying Yao, Heyangzi Li, Xi Cao, Chun-yan Fu, Mingzhi Zheng, Xinghui Song, Yueming Ding, Yueliang Shen, Jinjie Zhong, Ying-ying Chen, Jue Hu…
    Citation: Inflammation and Regeneration 2023 43:12
    Content type: Research article Published on:

  36. Canonical Wnt signaling is involved in a variety of biological processes including stem cell renewal and differentiation, embryonic development, and tissue regeneration. Previous studies reported the stage-spe...

    Authors: Takahiro Sogo, Shu Nakao, Tasuku Tsukamoto, Tomoe Ueyama, Yukihiro Harada, Dai Ihara, Tomoaki Ishida, Masato Nakahara, Koji Hasegawa, Yuka Akagi, Yasuyuki S. Kida, Osamu Nakagawa, Teruyuki Nagamune, Masahiro Kawahara and Teruhisa Kawamura
    Citation: Inflammation and Regeneration 2023 43:11
    Content type: Research article Published on:

  37. Inflammation can contribute to the development and progression of cancer. The inflammatory responses in the tumor microenvironment are shaped by complex sequences of dynamic intercellular cross-talks among div...

    Authors: Yoshinobu Konishi and Kenta Terai
    Citation: Inflammation and Regeneration 2023 43:10
    Content type: Review Published on:

  38. To date, many kinds of immune cells have been identified, but their precise roles in intestinal immunity remain unclear. Understanding the in vivo behavior of these immune cells and their function in gastroint...

    Authors: Masaki Honda, Masashi Kadohisa, Daiki Yoshii, Yoshihiro Komohara and Taizo Hibi
    Citation: Inflammation and Regeneration 2023 43:9
    Content type: Review Published on:

  39. Tissue stem cells are confined within a special microenvironment called niche. Stem cells in such a niche are supplied with nutrients and contacted by other cells to maintain their characters and also to keep ...

    Authors: Taichi Kashiwagi, Yuuki Takazawa, Tetsushi Kagawa and Tetsuya Taga
    Citation: Inflammation and Regeneration 2023 43:8
    Content type: Research article Published on:

  40. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of the infected individuals have asymp...

    Authors: Taisho Yamada and Akinori Takaoka
    Citation: Inflammation and Regeneration 2023 43:7
    Content type: Review Published on:

  42. Wound healing depends largely on the remodeling of the extracellular matrix around and reorganization of tissue-resident cells. Matrix remodeling associated 7 (MXRA7) is a member of the matrix remodeling-assoc...

    Authors: Ying Shen, Jinling Ning, Lu Zhao, Wei Liu, Ting Wang, Jie Yu and Yiqiang Wang
    Citation: Inflammation and Regeneration 2023 43:5
    Content type: Research article Published on:

  43. The coronavirus disease 2019 (COVID-19) pandemic is ongoing because of the repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, highlighting the importance of developing...

    Authors: Ryutaro Kotaki, Saya Moriyama and Yoshimasa Takahashi
    Citation: Inflammation and Regeneration 2023 43:4
    Content type: Review Published on:

  45. Blood coagulation factor XIII (FXIII) promotes cross-linking between fibrin molecules at the final stage of the blood coagulation cascade. However, its expression in cells or tissues and function, particularly...

    Authors: Hirofumi Watanabe, Sho Mokuda, Tadahiro Tokunaga, Hiroki Kohno, Michinori Ishitoku, Kei Araki, Tomohiro Sugimoto, Yusuke Yoshida, Toshihiro Yamamoto, Mayuko Matsumoto, Junya Masumoto, Shintaro Hirata and Eiji Sugiyama
    Citation: Inflammation and Regeneration 2023 43:2
    Content type: Research article Published on:

  50. Subarachnoid hemorrhage (SAH) is a fatal disease, with early brain injury (EBI) occurring within 72 h of SAH injury contributes to its poor prognosis. EBI is a complicated phenomenon involving multiple mechani...

    Authors: Hiroki Yamada, Yoshitaka Kase, Yuji Okano, Doyoon Kim, Maraku Goto, Satoshi Takahashi, Hideyuki Okano and Masahiro Toda
    Citation: Inflammation and Regeneration 2022 42:61
    Content type: Research article Published on:


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Inflammation and Regeneration

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