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  1. Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers. Notably, the comparative and longitudinal alterations in the pro...

    Authors: Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara and Hideyuki Okano
    Citation: Inflammation and Regeneration 2024 44:32
    Content type: Research article Published on:

  2. Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcino...

    Authors: Hye-Jin Boo, Hye-Young Min, Heung-Bin Lim, Euni Lee and Ho-Young Lee
    Citation: Inflammation and Regeneration 2024 44:31
    Content type: Research article Published on:

  3. The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. CX3CR1, the only receptor of CX3CL1, is specifically expressed on reti...

    Authors: Huan Yu, Bingqiao Shen, Ruiqi Han, Yang Zhang, Shushu Xu, Yumeng Zhang, Yanzhi Guo, Ping Huang, Shouyue Huang and Yisheng Zhong
    Citation: Inflammation and Regeneration 2024 44:30
    Content type: Research article Published on:

  4. Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheles...

    Authors: Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo and Keishi Fujio
    Citation: Inflammation and Regeneration 2024 44:29
    Content type: Research article Published on:

  5. Cellular senescence is the state in which cells undergo irreversible cell cycle arrest and acquire diverse phenotypes. It has been linked to chronic inflammation and fibrosis in various organs as well as to in...

    Authors: Yuki Saito, Sena Yamamoto and Takako S. Chikenji
    Citation: Inflammation and Regeneration 2024 44:28
    Content type: Review Published on:

  6. Regeneration of injured tissue is dependent on stem/progenitor cells, which can undergo proliferation and maturation processes to replace the lost cells and extracellular matrix (ECM). Bone has a higher regene...

    Authors: Yifan Qing, Takehito Ono, Yukihiro Kohara, Atsushi Watanabe, Noboru Ogiso, Masako Ito, Tomoki Nakashima and Sunao Takeshita
    Citation: Inflammation and Regeneration 2024 44:27
    Content type: Research article Published on:

  8. Extracellular vesicles (EVs) derived from dental pulp mesenchymal stem cells (DP-MSCs) are a promising therapeutic option for the treatment of myocardial ischemia. The aim of this study is to determine whether...

    Authors: Elena Amaro-Prellezo, Marta Gómez-Ferrer, Lusine Hakobyan, Imelda Ontoria-Oviedo, Esteban Peiró-Molina, Sonia Tarazona, Pedro Salguero, Amparo Ruiz-Saurí, Marta Selva-Roldán, Rosa Vives-Sanchez and Pilar Sepúlveda
    Citation: Inflammation and Regeneration 2024 44:25
    Content type: Research article Published on:

  9. It is known that maternal immunoglobulins (Igs) are transferred to the offspring across the placenta. However, receiving maternal Igs, especially before the blood–brain barrier (BBB) is formed in the offspring...

    Authors: Keiko Morimoto, Rikuo Takahashi, Goro Takahashi, Michio Miyajima and Kazunori Nakajima
    Citation: Inflammation and Regeneration 2024 44:24
    Content type: Research article Published on:

  10. Cancer tissues contain a wide variety of immune cells that play critical roles in suppressing or promoting tumor progression. Macrophages are one of the most predominant populations in the tumor microenvironme...

    Authors: Takahiro Matsui, Seiji Taniguchi and Masaru Ishii
    Citation: Inflammation and Regeneration 2024 44:23
    Content type: Review Published on:

  11. Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oli...

    Authors: Kenji Suzuki, Yukinori Sameshima, Junji Yokoyama, Shuji Terai, Hiroyuki Yoneyama, Raja Atreya, Markus F. Neurath, Toshifumi Hibi and Hitoshi Asakura
    Citation: Inflammation and Regeneration 2024 44:22
    Content type: Research article Published on:

  13. In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or...

    Authors: Sota Kurihara, Akihiro Ishikawa and Shin Kaneko
    Citation: Inflammation and Regeneration 2024 44:20
    Content type: Review Published on:

  17. Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by retarded alveolarization. Tenascin-C (TN-C), an extracellular matrix glycoprotein and soluble molecule, is involved in tissue morphog...

    Authors: Wei Liu, Yu Mao, Qianru Lv, Keyu Lu, Chunyu Yin, Rui Cheng and Mingshun Zhang
    Citation: Inflammation and Regeneration 2024 44:16
    Content type: Research article Published on:

  18. Cancer cell therapy, particularly chimeric antigen receptor (CAR) T-cell therapy for blood cancers, has emerged as a powerful new modality for cancer treatment. Therapeutic cells differ significantly from conv...

    Authors: Noyuri Zama and Satoshi Toda
    Citation: Inflammation and Regeneration 2024 44:15
    Content type: Review Published on:

  20. Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and imm...

    Authors: Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura and Hideyuki Okano
    Citation: Inflammation and Regeneration 2024 44:10
    Content type: Note Published on:

  22. The dynamic interaction and movement of substances and cells between the central nervous system (CNS) and peripheral organs are meticulously controlled by a specialized vascular structure, the blood–brain barr...

    Authors: Yuki Tanaka, Izuru Ohki, Kaoru Murakami, Satoshi Ozawa, Yaze Wang and Masaaki Murakami
    Citation: Inflammation and Regeneration 2024 44:12
    Content type: Review Published on:

  24. Staphylococcus aureus is a leading cause of human bacterial infections worldwide. It is the most common causative agent of skin and soft tissue infections, and can also cause various other infections, including p...

    Authors: Yuriko Yamazaki, Tomoka Ito, Masakazu Tamai, Seitaro Nakagawa and Yuumi Nakamura
    Citation: Inflammation and Regeneration 2024 44:9
    Content type: Review Published on:

  25. The development of induced pluripotent stem cells (iPSCs) technology has enabled human cellular disease modeling for inaccessible cell types, such as neural cells in the brain. However, many of the iPSC-derive...

    Authors: Sopak Supakul, Rei Murakami, Chisato Oyama, Tomoko Shindo, Yuki Hatakeyama, Maika Itsuno, Hiroko Bannai, Shinsuke Shibata, Sumihiro Maeda and Hideyuki Okano
    Citation: Inflammation and Regeneration 2024 44:8
    Content type: Research article Published on:

  26. Different neural subtypes are selectively lost in diverse neurodegenerative diseases. Huntington’s disease (HD) is an inherited neurodegenerative disease characterized by motor abnormalities that primarily aff...

    Authors: Junjiao Wu, Jie Ren, Hongfei Cui, Yali Xie and Yu Tang
    Citation: Inflammation and Regeneration 2024 44:7
    Content type: Research article Published on:

  27. Severe peripheral nerve damage always requires surgical treatment. Autologous nerve transplantation is a standard treatment, but it is not sufficient due to length limitations and extended surgical time. Even ...

    Authors: Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto…
    Citation: Inflammation and Regeneration 2024 44:6
    Content type: Research article Published on:

  29. In recent years, extracellular vesicles (EVs) have attracted significant attention as carriers in intercellular communication. The vast array of information contained within EVs is critical for various cellula...

    Authors: Tomohiro Minakawa and Jun K. Yamashita
    Citation: Inflammation and Regeneration 2024 44:4
    Content type: Review Published on:

  30. Thymosin beta family has a significant role in promoting hair regeneration, but which type of T cells play a key role in this process has not been deeply studied. This research aimed to find out the subtypes o...

    Authors: Nana Tao, Yuyuan Ying, Xie Xu, Qingru Sun, Yaoying Shu, Shiyu Hu, Zhaohuan Lou and Jianli Gao
    Citation: Inflammation and Regeneration 2024 44:3
    Content type: Research article Published on:

  31. Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases. The mechanisms behind the changes in intestinal bacteria in...

    Authors: Masataka Ichikawa, Haruka Okada, Nobuhiro Nakamoto, Nobuhito Taniki, Po-Sung Chu and Takanori Kanai
    Citation: Inflammation and Regeneration 2024 44:2
    Content type: Review Published on:

  36. Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively from donors. CB, a known source ...

    Authors: Tokiko Nagamura-Inoue and Fumitaka Nagamura
    Citation: Inflammation and Regeneration 2023 43:59
    Content type: Review Published on:

  37. The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the coordinated activities of multiple cell types and biomolecular factors...

    Authors: Khurshid Ahmad, Sibhghatulla Shaikh, Hee Jin Chun, Shahid Ali, Jeong Ho Lim, Syed Sayeed Ahmad, Eun Ju Lee and Inho Choi
    Citation: Inflammation and Regeneration 2023 43:58
    Content type: Review Published on:

  38. Exposure to a harsh ovarian microenvironment induced by chemotherapeutic agents seriously affects the remodeling of ovarian function and follicular development, leading to premature ovarian failure or insuffic...

    Authors: Yating Huang, Qiuwan Zhang, Wenjiao Cao, Qinyu Zhang, Lulu Wang and Dongmei Lai
    Citation: Inflammation and Regeneration 2023 43:57
    Content type: Research article Published on:

  39. Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococca...

    Authors: Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro Sato…
    Citation: Inflammation and Regeneration 2023 43:55
    Content type: Research article Published on:

  41. Inflammatory bowel disease (IBD) is a multifactorial intractable intestinal disease. Focusing on only one facet of the pathogenesis of IBD is insufficient to fully capture the complexity of the disease, and re...

    Authors: Sho Kitamoto and Nobuhiko Kamada
    Citation: Inflammation and Regeneration 2023 43:54
    Content type: Review Published on:

  42. Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin wounds heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation an...

    Authors: Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp, Doris Wilflingseder, Susanne Lobenwein, Dragana Savic, Leo Pölzl, Evi M. Morandi, Dolores Wolfram, Ira-Ida Skvortsova, Patrizia Stoitzner, Johannes Haybaeck…
    Citation: Inflammation and Regeneration 2023 43:53
    Content type: Research article Published on:

  43. Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation is central to the pathogenesis of BPD...

    Authors: Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch…
    Citation: Inflammation and Regeneration 2023 43:52
    Content type: Research article Published on:

  45. Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functi...

    Authors: Yu Suematsu, Narihito Nagoshi, Munehisa Shinozaki, Yoshitaka Kase, Yusuke Saijo, Shogo Hashimoto, Takahiro Shibata, Keita Kajikawa, Yasuhiro Kamata, Masahiro Ozaki, Kaori Yasutake, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura and Hideyuki Okano
    Citation: Inflammation and Regeneration 2023 43:50
    Content type: Research article Published on:

  46. Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system develop...

    Authors: Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N’dzie Noah and DianShuai Gao
    Citation: Inflammation and Regeneration 2023 43:49
    Content type: Research article Published on:

  47. The progression of liver fibrosis leads to portal hypertension and liver dysfunction. However, no antifibrotic agents have been approved for cirrhosis to date, making them an unmet medical need. Small extracel...

    Authors: Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, Masayuki Sano, Taketomo Kido, Yusuke Yoshioka, Junichi Kikuta, Tohru Itoh, Ken Nishimura…
    Citation: Inflammation and Regeneration 2023 43:48
    Content type: Research article Published on:

  48. Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. This study aimed to evaluate the effects of extracellular vesicles from placenta-deri...

    Authors: Wenjie Zheng, Saiyan Bian, Shi Qiu, Colin E. Bishop, Meimei Wan, Nuo Xu, Xieyin Sun, Russel Clive Sequeira, Anthony Atala, Zhifeng Gu and Weixin Zhao
    Citation: Inflammation and Regeneration 2023 43:47
    Content type: Research article Published on:

  49. Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant to anti-cancer drugs and a deeper unders...

    Authors: Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2023 43:46
    Content type: Research article Published on:

  50. Idiopathic pulmonary fibrosis (IPF) is a progressive aging-related lung disease with a poor prognosis. Despite extensive research, the cause of IPF remains largely unknown and treatment strategies are limited....

    Authors: Ryusuke Kizawa, Jun Araya and Yu Fujita
    Citation: Inflammation and Regeneration 2023 43:45
    Content type: Review Published on:


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Inflammation and Regeneration

ISSN: 1880-8190

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