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  1. Content type: Review

    Periodontopathic bacteria such as Porphyromonas gingivalis produce a large amount of butyric acid as a metabolite. Though butyric acid has been reported to have an anti-inflammatory effect on inflammatory disease...

    Authors: Michihiro Shirasugi, Maki Nakagawa, Keisuke Nishioka, Toshiro Yamamoto, Takaaki Nakaya and Narisato Kanamura

    Citation: Inflammation and Regeneration 2018 38:23

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  2. Content type: Case report

    In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a cas...

    Authors: Maho Nakazawa, Katsuya Suzuki, Hidekata Yasuoka, Kunihiro Yamaoka and Tsutomu Takeuchi

    Citation: Inflammation and Regeneration 2018 38:20

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  3. Content type: Research article

    Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibril...

    Authors: Ayaka Nakanishi, Naoe Kaneko, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Wei Zhou, Mie Kurata, Toshihiro Yamamoto, Sheikh Mohammad Fazle Akbar, Tamotsu Zako and Junya Masumoto

    Citation: Inflammation and Regeneration 2018 38:27

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  4. Content type: Review

    In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA seq...

    Authors: Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio and Kazuhiko Yamamoto

    Citation: Inflammation and Regeneration 2018 38:21

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  5. Content type: Review

    Mitochondria regulate not only cell functions through energy generation but also aging-associated cell phenotypes. Impaired mitochondrial structural and functional integrity accompanied by excessive mitochondr...

    Authors: Kazuya Tsubouchi, Jun Araya and Kazuyoshi Kuwano

    Citation: Inflammation and Regeneration 2018 38:18

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  6. Content type: Review

    Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injure...

    Authors: Hidetoshi Masumoto and Jun K. Yamashita

    Citation: Inflammation and Regeneration 2018 38:26

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  7. Content type: Review

    Morphological change in endothelial cells is an initial and crucial step in the process of establishing a functional vascular network. Following or associated with differentiation and proliferation, endothelia...

    Authors: Kiyomi Tsuji-Tamura and Minetaro Ogawa

    Citation: Inflammation and Regeneration 2018 38:25

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  8. Content type: Research article

    Atherosclerosis and inflammation are more common in patients with diabetes than in patients without diabetes, and atherosclerosis progression contributes to inflammation. Therefore, anti-inflammatory therapy i...

    Authors: Shiho Yamadera, Yuya Nakamura, Masahiro Inagaki, Sachiyo Kenmotsu, Tetsuhito Nohara, Naoki Sato, Tatsunori Oguchi, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Akihiko Yura, Yuji Kiuchi and Shinichi Iwai

    Citation: Inflammation and Regeneration 2018 38:13

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  9. Content type: Review

    Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli and lead to kidney fibrosis. Connective tissue g...

    Authors: Naohiro Toda, Masashi Mukoyama, Motoko Yanagita and Hideki Yokoi

    Citation: Inflammation and Regeneration 2018 38:14

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  10. Content type: Case report

    Cysts of the salivary glands are common lesions that occur in the context of various etiologies. Although the diagnostic importance of cysts in salivary gland diseases has been well studied, molecular mechanis...

    Authors: Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2018 38:12

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  11. Content type: Research article

    Zoledronic acid (Zol), one of the bisphosphonates, is frequently utilized for the treatment of osteoporosis and bone metastasis. However, the onset of medication-related osteonecrosis of the jaw (MRONJ) follow...

    Authors: Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga and Tatsuji Nishihara

    Citation: Inflammation and Regeneration 2018 38:16

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  12. Content type: Review

    Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic i...

    Authors: Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo, Tomomi Ichikawa and Toshinori Nakayama

    Citation: Inflammation and Regeneration 2018 38:10

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  13. Content type: Review

    Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic approach for geriatric disorders. The molecular mechanisms underlying age-related dysfunctions of specific types of a...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Hirotaka Kito, Aoi Matsubara, Mizuki Kaneda, Yu Katsuyama and Hayato Naka-Kaneda

    Citation: Inflammation and Regeneration 2018 38:9

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  14. Content type: Review

    Periodontal diseases are chronic infectious disease in which the pathogenic bacteria initiate the host immune response leading to the destruction of tooth supporting tissue and eventually result in the tooth l...

    Authors: Gurjeet Kaur, Vishakha Grover, Nandini Bhaskar, Rose Kanwaljeet Kaur and Ashish Jain

    Citation: Inflammation and Regeneration 2018 38:8

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  15. Content type: Review

    Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is ...

    Authors: Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka and Shuichi Matsuda

    Citation: Inflammation and Regeneration 2018 38:7

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  16. Content type: Review

    Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland...

    Authors: Naoto Azuma, Yoshinori Katada and Hajime Sano

    Citation: Inflammation and Regeneration 2018 38:6

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  17. Content type: Review

    The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maint...

    Authors: Ryu Okumura and Kiyoshi Takeda

    Citation: Inflammation and Regeneration 2018 38:5

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  18. Content type: Case report

    Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blocka...

    Authors: Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata and Ken-ichiro Seino

    Citation: Inflammation and Regeneration 2018 38:3

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  19. Content type: Research article

    MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyos...

    Authors: Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura and Iwao Sekigawa

    Citation: Inflammation and Regeneration 2018 38:1

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  20. Content type: Research article

    We previously reported that the mouse Ly6/Plaur domain containing 8 (mLypd8), a GPI-anchored protein highly and selectively expressed on colonic epithelia, contributes to segregation of intestinal microbiota a...

    Authors: Chiao-Ching Hsu, Ryu Okumura and Kiyoshi Takeda

    Citation: Inflammation and Regeneration 2017 37:23

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  21. Content type: Research article

    Abatacept, a CTLA4-Ig fusion protein attenuates T cell activation by inhibiting the CD80/86-CD28 costimulatory pathway that is required for the proper T cell activation and thus displays beneficial effects in ...

    Authors: Toshihiro Tono, Satoko Aihara, Takayuki Hoshiyama, Yoshiyuki Arinuma, Tatsuo Nagai and Shunsei Hirohata

    Citation: Inflammation and Regeneration 2017 37:24

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  22. Content type: Research article

    We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However...

    Authors: Miki Maehara, Masato Sato, Eriko Toyoda, Takumi Takahashi, Eri Okada, Tomomi Kotoku and Masahiko Watanabe

    Citation: Inflammation and Regeneration 2017 37:22

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  23. Content type: Review

    We recently developed novel cell transplantation method “cell transfer technology” utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patter...

    Authors: Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi and Ikuo Morita

    Citation: Inflammation and Regeneration 2017 37:21

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  24. Content type: Review

    Short-lived reactive nitrogen species and reactive oxygen species have acquired significant attention in the field of biomedical science. Nitric oxide (NO), which was thought to be an unstable gas and pollutan...

    Authors: Sandesh Panthi and Kripa Gautam

    Citation: Inflammation and Regeneration 2017 37:20

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    The Correction to this article has been published in Inflammation and Regeneration 2019 39:1

  25. Content type: Research article

    In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MS...

    Authors: Aya Fujishiro, Yasuo Miura, Masaki Iwasa, Sumie Fujii, Noriko Sugino, Akira Andoh, Hideyo Hirai, Taira Maekawa and Tatsuo Ichinohe

    Citation: Inflammation and Regeneration 2017 37:19

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  26. Content type: Review

    Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...

    Authors: Pornkawee Charoenlarp, Arun Kumar Rajendran and Sachiko Iseki

    Citation: Inflammation and Regeneration 2017 37:10

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  27. Content type: Review

    Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...

    Authors: Hironori Hara, Norifumi Takeda and Issei Komuro

    Citation: Inflammation and Regeneration 2017 37:13

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  28. Content type: Review

    Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...

    Authors: Sachiko Ono, Gyohei Egawa and Kenji Kabashima

    Citation: Inflammation and Regeneration 2017 37:11

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  29. Content type: Review

    Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...

    Authors: Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata and Shuji Terai

    Citation: Inflammation and Regeneration 2017 37:16

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  30. Content type: Review

    Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. Extensive recent studies ha...

    Authors: Pawinee Rerknimitr, Atsushi Otsuka, Chisa Nakashima and Kenji Kabashima

    Citation: Inflammation and Regeneration 2017 37:14

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  31. Content type: Review

    The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...

    Authors: Kenly Wuputra, Chang-Shen Lin, Ming-Ho Tsai, Chia-Chen Ku, Wen-Hsin Lin, Ya-Han Yang, Kung-Kai Kuo and Kazunari K. Yokoyama

    Citation: Inflammation and Regeneration 2017 37:15

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  32. Content type: Review

    The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...

    Authors: Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata and Junya Masumoto

    Citation: Inflammation and Regeneration 2017 37:9

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2017 Journal Metrics

  • Speed
    39 days to first decision for reviewed manuscripts only
    39 days to first decision for all manuscripts
    77 days from submission to acceptance
    19 days from acceptance to publication