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  1. Different neural subtypes are selectively lost in diverse neurodegenerative diseases. Huntington’s disease (HD) is an inherited neurodegenerative disease characterized by motor abnormalities that primarily aff...

    Authors: Junjiao Wu, Jie Ren, Hongfei Cui, Yali Xie and Yu Tang
    Citation: Inflammation and Regeneration 2024 44:7
  2. Severe peripheral nerve damage always requires surgical treatment. Autologous nerve transplantation is a standard treatment, but it is not sufficient due to length limitations and extended surgical time. Even ...

    Authors: Takayuki Nishijima, Kentaro Okuyama, Shinsuke Shibata, Hiroo Kimura, Munehisa Shinozaki, Takehito Ouchi, Yo Mabuchi, Tatsukuni Ohno, Junpei Nakayama, Manabu Hayatsu, Keiko Uchiyama, Tomoko Shindo, Eri Niiyama, Sayaka Toita, Jiro Kawada, Takuji Iwamoto…
    Citation: Inflammation and Regeneration 2024 44:6
  3. In recent years, extracellular vesicles (EVs) have attracted significant attention as carriers in intercellular communication. The vast array of information contained within EVs is critical for various cellula...

    Authors: Tomohiro Minakawa and Jun K. Yamashita
    Citation: Inflammation and Regeneration 2024 44:4
  4. Thymosin beta family has a significant role in promoting hair regeneration, but which type of T cells play a key role in this process has not been deeply studied. This research aimed to find out the subtypes o...

    Authors: Nana Tao, Yuyuan Ying, Xie Xu, Qingru Sun, Yaoying Shu, Shiyu Hu, Zhaohuan Lou and Jianli Gao
    Citation: Inflammation and Regeneration 2024 44:3
  5. Recent advances in the analysis of intestinal bacteria have led to reports of variations in intestinal bacterial levels among hepatobiliary diseases. The mechanisms behind the changes in intestinal bacteria in...

    Authors: Masataka Ichikawa, Haruka Okada, Nobuhiro Nakamoto, Nobuhito Taniki, Po-Sung Chu and Takanori Kanai
    Citation: Inflammation and Regeneration 2024 44:2
  6. Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively from donors. CB, a known source ...

    Authors: Tokiko Nagamura-Inoue and Fumitaka Nagamura
    Citation: Inflammation and Regeneration 2023 43:59
  7. The regenerative ability of skeletal muscle (SM) in response to damage, injury, or disease is a highly intricate process that involves the coordinated activities of multiple cell types and biomolecular factors...

    Authors: Khurshid Ahmad, Sibhghatulla Shaikh, Hee Jin Chun, Shahid Ali, Jeong Ho Lim, Syed Sayeed Ahmad, Eun Ju Lee and Inho Choi
    Citation: Inflammation and Regeneration 2023 43:58
  8. Exposure to a harsh ovarian microenvironment induced by chemotherapeutic agents seriously affects the remodeling of ovarian function and follicular development, leading to premature ovarian failure or insuffic...

    Authors: Yating Huang, Qiuwan Zhang, Wenjiao Cao, Qinyu Zhang, Lulu Wang and Dongmei Lai
    Citation: Inflammation and Regeneration 2023 43:57
  9. Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococca...

    Authors: Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro Sato…
    Citation: Inflammation and Regeneration 2023 43:55
  10. Inflammatory bowel disease (IBD) is a multifactorial intractable intestinal disease. Focusing on only one facet of the pathogenesis of IBD is insufficient to fully capture the complexity of the disease, and re...

    Authors: Sho Kitamoto and Nobuhiko Kamada
    Citation: Inflammation and Regeneration 2023 43:54
  11. Chronic non-healing wounds pose a global health challenge. Under optimized conditions, skin wounds heal by the formation of scar tissue. However, deregulated cell activation leads to persistent inflammation an...

    Authors: Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp, Doris Wilflingseder, Susanne Lobenwein, Dragana Savic, Leo Pölzl, Evi M. Morandi, Dolores Wolfram, Ira-Ida Skvortsova, Patrizia Stoitzner, Johannes Haybaeck…
    Citation: Inflammation and Regeneration 2023 43:53
  12. Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation is central to the pathogenesis of BPD...

    Authors: Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch…
    Citation: Inflammation and Regeneration 2023 43:52
  13. Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functi...

    Authors: Yu Suematsu, Narihito Nagoshi, Munehisa Shinozaki, Yoshitaka Kase, Yusuke Saijo, Shogo Hashimoto, Takahiro Shibata, Keita Kajikawa, Yasuhiro Kamata, Masahiro Ozaki, Kaori Yasutake, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura and Hideyuki Okano
    Citation: Inflammation and Regeneration 2023 43:50
  14. Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system develop...

    Authors: Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N’dzie Noah and DianShuai Gao
    Citation: Inflammation and Regeneration 2023 43:49
  15. The progression of liver fibrosis leads to portal hypertension and liver dysfunction. However, no antifibrotic agents have been approved for cirrhosis to date, making them an unmet medical need. Small extracel...

    Authors: Nobutaka Takeda, Atsunori Tsuchiya, Masaki Mito, Kazuki Natsui, Yui Natusi, Yohei Koseki, Kei Tomiyoshi, Fusako Yamazaki, Yuki Yoshida, Hiroyuki Abe, Masayuki Sano, Taketomo Kido, Yusuke Yoshioka, Junichi Kikuta, Tohru Itoh, Ken Nishimura…
    Citation: Inflammation and Regeneration 2023 43:48
  16. Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. This study aimed to evaluate the effects of extracellular vesicles from placenta-deri...

    Authors: Wenjie Zheng, Saiyan Bian, Shi Qiu, Colin E. Bishop, Meimei Wan, Nuo Xu, Xieyin Sun, Russel Clive Sequeira, Anthony Atala, Zhifeng Gu and Weixin Zhao
    Citation: Inflammation and Regeneration 2023 43:47
  17. Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant to anti-cancer drugs and a deeper unders...

    Authors: Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2023 43:46
  18. Idiopathic pulmonary fibrosis (IPF) is a progressive aging-related lung disease with a poor prognosis. Despite extensive research, the cause of IPF remains largely unknown and treatment strategies are limited....

    Authors: Ryusuke Kizawa, Jun Araya and Yu Fujita
    Citation: Inflammation and Regeneration 2023 43:45
  19. The types of bone damage in rheumatoid arthritis (RA) include joint erosion, periarticular osteoporosis, and systemic osteoporosis. Janus kinase (JAK) inhibitors ameliorate inflammation and joint erosion in RA...

    Authors: Masatsugu Komagamine, Noriko Komatsu, Rui Ling, Kazuo Okamoto, Shi Tianshu, Kotaro Matsuda, Tsutomu Takeuchi, Yuko Kaneko and Hiroshi Takayanagi
    Citation: Inflammation and Regeneration 2023 43:44
  20. Disease-specific induced pluripotent stem cells (iPSCs) are useful tools for pathological analysis and diagnosis of rare diseases. Given the limited available resources, banking such disease-derived iPSCs and ...

    Authors: Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi and Shinya Yamanaka
    Citation: Inflammation and Regeneration 2023 43:43
  21. Crosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the “AhR–Nrf2 gene battery”, which works synergistically in detoxification to su...

    Authors: Kenly Wuputra, Ming-Ho Tsai, Kohsuke Kato, Chia-Chen Ku, Jia-Bin Pan, Ya-Han Yang, Shigeo Saito, Chun-Chieh Wu, Ying-Chu Lin, Kuang-Hung Cheng, Kung-Kai Kuo, Michiya Noguchi, Yukio Nakamura, Tohru Yoshioka, Deng-Chyang Wu, Chang-Shen Lin…
    Citation: Inflammation and Regeneration 2023 43:42
  22. During mouse embryonic development, definitive hematopoiesis is first detected around embryonic day (E) 10.5 in the aorta-gonad-mesonephros (AGM) region. Hematopoietic stem cells (HSCs) arise in the dorsal aor...

    Authors: Gerel Melig, Ikuo Nobuhisa, Kiyoka Saito, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai-Azuma, Mitsujiro Osawa, Motohiko Oshima, Atsushi Iwama and Tetsuya Taga
    Citation: Inflammation and Regeneration 2023 43:41
  23. Recently accumulating evidence identified the disease entity where astrocytes residing within the central nervous system (CNS) are the target of autoantibody-mediated autoimmunity. Aquaporin4 (AQP4) is the mos...

    Authors: Makoto Kinoshita and Tatsusada Okuno
    Citation: Inflammation and Regeneration 2023 43:39
  24. Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic me...

    Authors: Shota Yamamoto and Takahiro Masuda
    Citation: Inflammation and Regeneration 2023 43:38
  25. Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injur...

    Authors: Tian Lan, Yang Tai, Chong Zhao, Yang Xiao, Zhu Yang, Linhao Zhang, Can Gan, Wenting Dai, Huan Tong, Chengwei Tang, Zhiyin Huang and Jinhang Gao
    Citation: Inflammation and Regeneration 2023 43:37
  26. Impaired wound re-epithelialization contributes to cutaneous barrier reconstruction dysfunction. Recently, N6-methyladenosine (m6A) RNA modification has been shown to participate in the determination of RNA fate,...

    Authors: Xin Huang, Yixuan Zhao, Daiming Liu, Shuchen Gu, Yunhan Liu, Yimin Khoong, Shenying Luo, Zewei Zhang, Wenzheng Xia, Meng Wang, Hsin Liang, Minxiong Li, Qingfeng Li and Tao Zan
    Citation: Inflammation and Regeneration 2023 43:36
  27. This study aimed to investigate how aging alters the homeostasis of the colonic intestinal epithelium and regeneration after tissue injury using organoid models and to identify its underlying molecular mechanism.

    Authors: Min Kyoung Jo, Chang Mo Moon, Hyeon-Jeong Jeon, Yerim Han, Eun Sook Lee, Ji-Hee Kwon, Kyung-Min Yang, Young-Ho Ahn, Seong-Eun Kim, Sung-Ae Jung and Tae Il Kim
    Citation: Inflammation and Regeneration 2023 43:35
  28. Bone defects remain a challenge today. In addition to osteogenic activation, the crucial role of angiogenesis has also gained attention. In particular, vascular endothelial growth factor (VEGF) is likely to pl...

    Authors: Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Jia Deng, Noriyuki Wakabayashi and Keiji Itaka
    Citation: Inflammation and Regeneration 2023 43:32
  29. In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various retinal/optic neuropathies, increasing evidence has shown that the external ...

    Authors: Zi-Yuan Zhang, Zhao-Yang Zuo, Yang Liang, Si-Ming Zhang, Chun-Xia Zhang, Jing Chi, Bin Fan and Guang-Yu Li
    Citation: Inflammation and Regeneration 2023 43:31
  30. Aging of the global population increases the incidence of osteoporosis and associated fragility fractures, significantly impacting patient quality of life and healthcare costs. The acute inflammatory reaction ...

    Authors: Junichi Kushioka, Simon Kwoon-Ho Chow, Masakazu Toya, Masanori Tsubosaka, Huaishuang Shen, Qi Gao, Xueping Li, Ning Zhang and Stuart B. Goodman
    Citation: Inflammation and Regeneration 2023 43:29
  31. Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d. iNKT cells express an invariant T cell receptor (...

    Authors: Takahiro Aoki, Shinichiro Motohashi and Haruhiko Koseki
    Citation: Inflammation and Regeneration 2023 43:27
  32. Authors: Cassandra Margotta, Paola Fabbrizio, Marco Ceccanti, Chiara Cambieri, Gabriele Rufolo, Jessica D’Agostino, Maria Chiara Trolese, Pierangelo Cifelli, Veronica Alfano, Christian Laurini, Silvia Scaricamazza, Alberto Ferri, Gianni Sorarù, Eleonora Palma, Maurizio Inghilleri, Caterina Bendotti…
    Citation: Inflammation and Regeneration 2023 43:25

    The original article was published in Inflammation and Regeneration 2023 43:19

  33. Human mesenchymal stromal cell (MSC)-derived extracellular vesicles (EV) revealed neuroprotective potentials in various brain injury models, including neonatal encephalopathy caused by hypoxia–ischemia (HI). H...

    Authors: Nicole Labusek, Yanis Mouloud, Christian Köster, Eva Diesterbeck, Tobias Tertel, Constanze Wiek, Helmut Hanenberg, Peter A. Horn, Ursula Felderhoff-Müser, Ivo Bendix, Bernd Giebel and Josephine Herz
    Citation: Inflammation and Regeneration 2023 43:24
  34. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is an inherited cerebral small vessel disease (CSVD) caused by biallelic mutations in the high-temperature req...

    Authors: Emi Qian, Masahiro Uemura, Hiroya Kobayashi, Shiho Nakamura, Fumiko Ozawa, Sho Yoshimatsu, Mitsuru Ishikawa, Osamu Onodera, Satoru Morimoto and Hideyuki Okano
    Citation: Inflammation and Regeneration 2023 43:23
  35. Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative a...

    Authors: Pengxiang Zhao, Zheng Dang, Mengyu Liu, Dazhi Guo, Ruiliu Luo, Mingzi Zhang, Fei Xie, Xujuan Zhang, Youbin Wang, Shuyi Pan and Xuemei Ma
    Citation: Inflammation and Regeneration 2023 43:22
  36. Since the discovery of group 2 innate lymphoid cells (ILC2s) in 2010, subsequent studies have revealed their developmental pathways, mechanisms of activation and regulation, and immunological roles in tissue h...

    Authors: Maiko Naito and Atsushi Kumanogoh
    Citation: Inflammation and Regeneration 2023 43:21
  37. Alzheimer’s disease (AD) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (Aβ) aggregates and phosphorylated tau with aging. The aggregation of Aβ, whi...

    Authors: Ryusei Kaneko, Ako Matsui, Mahiro Watanabe, Yoshihiro Harada, Mitsuhiro Kanamori, Natsumi Awata, Mio Kawazoe, Tomoaki Takao, Yutaro Kobayashi, Chie Kikutake, Mikita Suyama, Takashi Saito, Takaomi C. Saido and Minako Ito
    Citation: Inflammation and Regeneration 2023 43:20


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