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Table 2 Hematopoiesis-associated characteristics of five lots of BM-MSCs that were exposed to 0.1 Gy γ-radiation.

From: Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells

  Lot of BM-MSCs
Phase of BM-MSCs after low-dose γ-irradiation Characteristics of low-dose γ-irradiated BM-MSCs A C B D E
Early phase (24 hours) Enhanced generation of CD34+CD38+ cells from HPCs + +
Increased expression of IL-6/Decreased expression of SCF and Flt3L + +
Late phase (3 weeks) Enhanced generation of CD34+CD38+ cells from HPCs n.t. n.t. n.t.
Increased expression of IL-6/Decreased expression of SCF and Flt3L n.t. n.t. n.t.
  1. BM-MSCs bone marrow mesenchymal stromal/stem cells, HPCs hematopoietic stem/progenitor cells, IL-6 interleukin-6, SCF stem cell factor, Flt3L fms-related tyrosine kinase 3 ligand, n.t. not tested