Effects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells

Table 2 Hematopoiesis-associated characteristics of five lots of BM-MSCs that were exposed to 0.1 Gy γ-radiation.

		Lot of BM-MSCs
Phase of BM-MSCs after low-dose γ-irradiation	Characteristics of low-dose γ-irradiated BM-MSCs	A	C	B	D	E
Early phase (24 hours)	Enhanced generation of CD34⁺CD38⁺ cells from HPCs	+	+	−	−	−
Early phase (24 hours)	Increased expression of IL-6/Decreased expression of SCF and Flt3L	+	+	−	−	−
Late phase (3 weeks)	Enhanced generation of CD34⁺CD38⁺ cells from HPCs	−	−	n.t.	n.t.	n.t.
Late phase (3 weeks)	Increased expression of IL-6/Decreased expression of SCF and Flt3L	−	−	n.t.	n.t.	n.t.

BM-MSCs bone marrow mesenchymal stromal/stem cells, HPCs hematopoietic stem/progenitor cells, IL-6 interleukin-6, SCF stem cell factor, Flt3L fms-related tyrosine kinase 3 ligand, n.t. not tested

ISSN: 1880-8190