Fig. 2From: Endocannabinoids and related N-acylethanolamines: biological activities and metabolismMetabolism of 2-AG. Red thick arrows represent the major pathway. H2O is omitted in the hydrolytic reactions. Two hydroxyl groups indicated by asterisks are phosphorylated in the case of 2-arachidonoyl-phosphatidylinositol 4,5-bisphosphate. Numbers of acyl chains per molecule are indicated in parentheses. COX-2 cyclooxygenase-2, DDHD1 DDHD domain containing 1, PLC phospholipase CBack to article page