Fig. 3
From: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
Roles of the 12-HHT-LTB4 receptor 2 (BLT2) axis in lung injury. PLY treatment induces the production of large amounts of cysteinyl leukotrienes (CysLTs) from mast cells. The CysLT1 receptor antagonist ameliorates PLY-induced mortality, vascular permeability, and airway resistance. 12-HHT-BLT2 axis suppresses CysLT1 signaling in vascular endothelial cells and smooth muscle cells, but the detailed molecular mechanism is under investigation