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Table 3 Territorial Structure of hyaline articular cartilage [8]

From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review

  Location Collagen fibers Proteoglycans Function
1 Pericellular matrix
Type II, VI, and IX concentrated in the pericellular network of thin fibrils as fibronectin. Mainly proteoglycans as aggrecan, hyaluronan and decorin, glycoproteins, and other non-collagenous proteins Functional role to initiate signal transduction within cartilage with load bearing
2 (The territorial matrix)
This region is thicker than the pericellular matrix
Fine collagen fibrils, forming a basketlike network around the cells
Type VI collagen microfibrils but little or no fibrillar collagen.
High concentrations May protect the cartilage cells against mechanical stresses and may contribute to the resiliency of the articular cartilage structure and its ability to withstand a substantial load
  The interterritorial matrix
largest of the 3 matrix regions; it contributes most to the biomechanical properties of articular cartilage
Large collagen type IV fibers
Randomly oriented bundles of large collagen fibrils, as zonal structure
collagen type II, type XI collagen and type IX collagen
Are abundant Bulk of articular cartilage
permitting association with other matrix components and retention of proteoglycans. These collagens give to the cartilage form, tensile stiffness, and strength