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Table 2 Small molecular fluorescent probes for intravital multiphoton imaging in bone

From: Intravital imaging of orthotopic and ectopic bone

Small molecular probe

Fluorescence

Cell function

Report

(development)

Report

(intravital imaging)

BAp-E

Green

Bone resorption (osteoclast)

Kowada et al. J Am Chem Soc. (2011) [21].

Kikuta et al. J. Clin. Invest. (2013) [12].

pHocas-3

Green

Bone resorption (osteoclast)

Maeda et al. Nat. Chem. Biol. (2016) [22].

Furuya et al. Nat. Commun. (2018) [13].

  1. BAp-E boron-dipyrromethene-based (BODIPY-based) H+-sensing fluorescent probe, pHocas-3 pH-activatable fluorescent probe for osteoclast activity sensing-3