Fig. 1
From: Cerebral sterile inflammation in neurodegenerative diseases
Induction of sterile neuroinflammation. ATP, uric acid, and other DAMPs released from the damaged cells activate microglia and macrophages infiltrating through disrupted BBB. Activated microglia and macrophages produce inflammatory cytokines including the activator of infiltrating T lymphocytes, resulting in the sustained neuroinflammation that leads to further cell death and progression of CNS pathologies