Fig. 2
From: Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
A schema of various immune regulation approaches. a Transplantation of thymic antigen-presenting cells prior to iPSC-derived allogeneic cells/tissue to induce donor-specific immune tolerance. b Simultaneous transplantation of iPSC-derived allogeneic cells/tissue and syngeneic mesenchymal stem cells (MSCs) to induce immune tolerance. c Modulation of HLAs of allogeneic iPSCs to circumvent CD8+ cytotoxic T cells and natural killer cells (NK cells)-mediated immune responses