Table 1 Strategies of immune regulation other than HLA-matching
From: Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
Author | Strategy | Graft | Recipient | Mechanism of immune tolerance | Ref. |
|---|---|---|---|---|---|
Otsuka et al. | Transplantation with iPSC-derived immunogenicity cells | Tissues derived from iPSCs | Allogeneic animal | iPSC-derived antigens induce donor-specific immune tolerance | [29] |
Yoshida et al. | Transplantation with syngeneic MSCs | Tissues derived from iPSCs | Allogeneic animal | Syngeneic MSCs induce Treg cells and the apoptosis of CD8+ T cells for graft | [30] |
Xu et al. | Universal cells by genomic editing | Tissues derived from HLA-modulated iPSCs | Allogeneic animal | Inducing tolerances from CD8+ cytotoxic T cells and NK cells | [31] |
Rong et al. | Universal cells by genomic editing | Cells derived from immune-modified ESCs | Allogeneic animal | The expression of immunomodulatory transgenes | [32] |