Fig. 5From: Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settingsEngineered PSCs designed to prevent the immunological rejection.Based on the disruption of HLA expression on PSCs, CD47 was overexpressed to prevent the engulfment by phagocytosis (a), HLA-E molecule was overexpressed (b), CD47, PD-L1, and HLA-G were overexpressed (c), HLA-C molecules were retained in HLA-homo-iPSCs (d)Back to article page