Fig. 4From: Molecular biology of autoinflammatory diseasesActivation of pyrin inflammasome is inhibited by phosphorylation by PKN1/2. Upon bacterial infection, bacterial toxin can inhibit PKN1/2 activity, resulting in pyrin inflammasome activation. The L293F mutation in WDR1 leads to actin accumulation and aggregates with pyrin, resulting in pyrin activationBack to article page