Fig. 1
From: Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
IL-6 signaling. D1āD3, subdomains of IL-6RĪ±; gp130, glycoprotein 130; IL-6, interleukin-6; IL-6R, interleukin-6 receptor; JAK, Janus kinase; mAb, monoclonal antibody; MAPK, mitogen-activated protein kinase; sgp, soluble glycoprotein 130; SHP2, Src homology region 2 domainācontaining phosphatase-2; sIL-6R, soluble IL-6R; STAT3, signal transducer and activator of transcription 3