Fig. 4
From: Endothelial-specific depletion of TGF-β signaling affects lymphatic function
LEC-specific TβRII deletion does not affect tumor growth. a LLC cells were subcutaneously transplanted into Tx-treated control or TβRIIiΔLEC mice. Tumor size was measured from above the skin at the indicated days. Tumor volumes were calculated using the formula: length × width × width × 0.5. The data presented are the means ± S.D. (n = 6) b Tumor weight 15 days after LLC transplantation. (n = 6) c Appearance of xenografted tumors transplanted into control or TβRIIiΔLEC mice 15 days after LLC transplantation. TβRIIiΔLEC mice had tissue fluid accumulation around tumor (arrows). Representative images are shown. Scale bar: 5 mm. d Immunohistostaining of the tumor sections with anti-PECAM-1 (green) and anti-VEGFR3 (red) antibodies. Sections were counterstained with DAPI (nucleus, blue). Scale bar: 50 μm