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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

Fig. 1

Therapeutic effects of ONO-1301 (20 weeks of treatment) in the Mc4r-KO NASH model mice. Mc4r-KO mice were fed a Western diet from 8 weeks of age and followed up for an additional 20 weeks. A Schematic of the experiment. B Serum levels of albumin (ALB), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (T-Bil), total cholesterol (T-cho), and triglyceride (TG). Liver-to-body weight ratios were analyzed. C Sirius Red staining of liver tissues. Scale bar = 500 μm. The quantification of Sirius Red staining. D Quantification of hydroxyproline. E Immunohistochemistry of F4/80 and quantification of hepatic crown-like structures (hCLS). F The levels of cAMP in the liver tissues. Scale bar = 50 μm. Total number of mice in each group: n = 6–10 in Ctl group, n = 6–15 in ONO group. Data are presented as mean ± standard deviation. ns: not significant

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Inflammation and Regeneration

ISSN: 1880-8190

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