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Fig. 5 | Inflammation and Regeneration

Fig. 5

From: Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition

Fig. 5

Model of EndoMT and vascular destabilization induced by oral cancer cell-derived EVs. Oral cancer cells that undergo TGF-β-induced EMT increase the release of EVs. These TGF-β-stimulated cell-derived EVs induce EndoMT in vascular endothelial cells, which leads to decreased intercellular adhesion in vascular endothelial cells and increased vascular permeability. Hence, oral cancer cells that have undergone TGF-β-induced EMT may contribute to cancer metastasis by enhancing EndoMT-associated vascular destabilization in vascular endothelial cells via EVs

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Inflammation and Regeneration

ISSN: 1880-8190

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