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Fig. 6 | Inflammation and Regeneration

Fig. 6

From: 2D and 3D cultured human umbilical cord-derived mesenchymal stem cell-conditioned medium has a dual effect in type 1 diabetes model in rats: immunomodulation and beta-cell regeneration

Fig. 6

Immunohistochemical analyzes. A Immunohistochemical analyzes showing numbers of the Nkx6.1, Pdx1-positive, and insulin-positive areas in the pancreatic islets, × 40. B Percentage of the Nkx6.1-positive cells in the islets. ap < 0.001 versus the C group, bp < 0.001 versus the C+2D-CM group, cp < 0.001 according to the C+3D group. C Percentage of the Pdx1-positive cells in the islets. ap < 0.001 versus the C group, bp < 0.001 versus the C+2D-CM group, cp < 0.001 versus the C+3D-CM group, dp < 0.001 according to the D group. D Percentage of insulin positivity in the islets. ap < 0.001versus the C group, bp < 0.001 versus the C+2D-CM group, cp < 0.001 versus the C+3D-CM group, dp < 0.01 versus the D group, ep < 0.05 versus the D+2D-CM group. Scale bar: 20 ul

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