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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19

Fig. 4

Enhanced expression of MACROH2A1 in monocytes and macrophages of fatal COVID-19 lungs revealed by snRNA-seq. a Overview of single-cell analysis of lung transcriptome obtained from patients with fatal COVID-19 and controls (previous study: Melms et al. (2021)). b UMAP embedding of snRNA data analysis of lungs obtained from fatal COVID-19 cases and controls. c RNA expression levels (log-normalized) of MACROH2A1 in each of the controls and fatal COVID-19 cases. d Violin plots of MACROH2A1 expression in each lung cell of controls and fatal COVID-19 cases. e Differential expression analysis of MACROH2A1 in monocytes and macrophages. The y-axis indicates expression changes of fatal COVID-19 cases relative to controls. **p < 0.01, ***p < 0.001

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Inflammation and Regeneration

ISSN: 1880-8190

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