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Table 3 Functional pathways and categories included in the top enriched pathway in Fig. 1i

From: Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19

Categories

Diseases or functions annotation

P value

Molecules

# Molecules

Infectious diseases, organismal injury and abnormalities

Severe COVID-19

9.63 × 10−15

ACSL1, APOL1, C4A/C4B, C4BPA, C5, C6, FCN2, HLA-DQB1, ITIH3, ITIH4, PF4, PLBD1, SAA1, SAA2, SELL, SPARC, TNFAIP2, TXNIP

18

Infectious diseases, organismal injury and abnormalities

Viral Infection

1.22 × 10−10

ABCB1, ABCE1, ACSL1, APOL1, APP, ARPC1b, ARPC5, BGN, C2, C4A/C4B, C4BPA, C5, C6, CAMP, CD14, CD247, CD93, CHMP6, CLTA, COLEC10, DBN1, DDOST, EPS15, FCN2, GPX1, HLA-DQB1, IGHM, ITIH3, ITIH4, ITLN1, JCHAIN, LPL, MUC5B, NPC1L1, PACSIN3, PCSK9, PF4, PLBD1, PLCG2, PNN, PURA, RABEP1, SAA1, SAA2, SELL, SERPINA10, SMPDL3B, SPARC, SPP1, TMX1, TNFAIP2, TPM3, TXNIP, WWP1, ZMPSTE24

55

Infectious diseases, organismal injury and abnormalities

COVID-19

1.44 × 10−10

ABCB1, ACSL1, APOL1, C4A/C4B, C4BPA, C5, C6, DBN1, FCN2, GPX1, HLA-DQB1, ITIH3, ITIH4, PCSK9, PF4, PLBD1, SAA1, SAA2, SELL, SPARC, TMX1, TNFAIP2, TXNIP

23

Infectious diseases, organismal injury and abnormalities

Infection by RNA virus

6.59 × 10−10

ABCB1, ACSL1, APOL1, APP, ARPC1B, ARPC5, C2, C4A/C4B, C4BPA, C5, C6, CD14, CD93, CLTA, DBN1, DDOST, EPS15, FCN2, GPX1, HLA-DQB1, IGHM, ITIH3, ITIH4, LPL, MUC5B, NPC1L1, PACSIN3, PCSK9, PF4, PLBD1, PURA, SAA1, SAA2, SELL, SPARC, SPP1, TMX1, TNFAIP2, TXNIP, ZMPSTE24

40

Infectious diseases, organismal injury and abnormalities

Infection of mammalian

6.64 × 10−8

ADAMTS13, C4A/C4B, CAMP, CD14, CD5L, DCN, HLA-DQB1, IGHM, JCHAIN, MPO, MUC5AC, MUC5B, NRROS, OLFM4, PIGR, PLCG2, SPP1

17

Infectious diseases, inflammatory disease, organismal injury and abnormalities, respiratory disease

Severe acute respiratory syndrome

0.0000417

ACSL1, CAMP, CD14, CD247, GPX1, PNN, SMPDL3B, SPARC, TPM3

9

Infectious diseases, organismal injury and abnormalities

Sepsis

0.0000826

C4A/C4B, C5, CAMP, CD14, FSTL1, HLA-DQB1, LRP1, MPO, MUC5B, SPP1, TGM2

11

Infectious diseases, organismal injury and abnormalities, respiratory disease

Infection of respiratory tract

0.000181

ACSL1, CAMP, CD14, CD247, GPX1, PNN, SAA1, SMPDL3B, SPARC, TPM3

10

Infectious diseases, organismal injury and abnormalities

Tuberculosis

0.000228

ABCB1, CAMP, CD14, CTSG, MPO, OLFM4, SELL, SPP1

8

Infectious diseases, organismal injury and abnormalities

Infection by Neisseria meningitidis

0.000542

C5, C9

2

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Inflammation and Regeneration

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