Fig. 1
From: State-of-the-art liver disease research using liver-on-a-chip
Recapitulation of hepatic zonation using liver-on-a-chips. A A schematic image of hepatic lobules. B A schematic image of the hepatic cord. C The design of metabolic patterning on a chip (MPOC) with a Christmas-tree-like gradient generator. Medium containing glucagon was injected into one of the inlets of the gradient generator, and medium containing insulin was injected into the other inlet. Adapted with permission under a Creative Commons CC BY 4.0 License from ref [9]. Copyright 2018 Springer Nature. D The design of a liver lobule chip (LLC). The LLC is composed of a portal vein- and hepatic artery-like perfusion inlet and central vein-like outlet. Reprinted with permission from ref [10]. Copyright 2021 American Chemical Society