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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

Fig. 3

CD8+ T cells inhibit NSC proliferation via the IFN-γ-Stat1 pathway in vitro. A Experimental design, CM: conditioned medium. B Flow cytometry showing EdU-positive NSCs (proliferative NSCs) with CD8+ T-cell-derived conditioned medium with or without an anti-IFN-γ antibody. C Statistical graph of B. n = 6. ***P < 0.001, ****P < 0.0001, one-way ANOVA with Tukey. D–I Western blotting showing the expression levels of Stat1, p-Stat1 (Tyr705), and P27 in NSCs. n = 4. *P < 0.05, ****P < 0.0001, one-way ANOVA with Tukey. J Experimental design, CM, conditioned medium. K Flow cytometry showing EdU-positive NSCs with CD8+ T-cell-derived conditioned medium with or without Stat1 knockdown. L A statistical graph of K. n = 6. ****P < 0.0001, one-way ANOVA with Tukey

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Inflammation and Regeneration

ISSN: 1880-8190

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