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Fig. 7 | Inflammation and Regeneration

Fig. 7

From: Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

Fig. 7

IL-1α stimulated hair follicle conversion from telogen to anagen phase and induced Lgr5 HFSCs proliferation in 7W mice. A Experimental steps. B Representative photos of mice on the 14th day after treatment. Blue arrows direct the control (PBS) area, and red arrows direct the treatment (IL-1α) area. C IL-1α increased outer hair length (PBS vs IL-1α, 1.304 ± 0.3546 vs 2.298 ± 0.3026, n = 12) (D) Representative pictures of HE and Sirius Red staining from the same mouse. E IL-1α increased HFs size. (PBS vs IL-1α, 0.6032 ± 0.04112 vs1.146 ± 0.09502, n = 8). F IL-1α increased skin thickness (PBS vs IL-1α, 1.316 ± 0.1599 vs 2.184 ± 0.2040, n = 8). G Representative pictures from Lgr5 + /mTmG mice (n = 8). *P < 0.05, **P < 0.01, ***P < 0.005

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Inflammation and Regeneration

ISSN: 1880-8190

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