Fig. 5
From: Group 2 innate lymphoid cells and their surrounding environment
Regulation of ILC2s by mesenchymal cells. ILC2s localize with fibroblast-like mesenchymal cells in perivascular regions. Mesenchymal cells produce IL-33 and TSLP to support ILC2s, and ILC2s promote mesenchymal cell expansion and IL-33 production during helminth infection. Mesenchymal cells not only activate ILC2s but also regulate IL-10 production via Semaphorine6D-PlexinA1 manner