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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1

Fig. 1

Clinical findings of the patient carrying the heterozygous HTRA1 mutation. a Family pedigree of the patient with heterozygous HTRA1-related CSVD. Squares, men; circles, women; filled symbols, individuals with a history of a stroke; a filled arrow, the donor for iPSC establishment; diagonal lines through symbols, deceased members. b Image of magnetic resonance angiography (MRA) acquired at the age of 69. ACA; anterior cerebral artery, MCA; middle cerebral artery, ICA; internal carotid artery, BA; basilar artery, L, left; R, right; AP, anterior superior; PI, posterior inferior. c. Fluid-attenuated inversion recovery (FLAIR) image of the brain magnetic resonance imaging (MRI) acquired at the age of 69. Ischemic changes are indicated by arrowheads. L left; R, right; A, anterior; P, posterior. d. T2*-weighted Image (T2*WI) of the brain MRI acquired at the age of 69. Microbleeds are marked with arrowheads

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Inflammation and Regeneration

ISSN: 1880-8190

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