Fig. 1
From: The Ragulator complex: delving its multifunctional impact on metabolism and beyond
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex. Overall structures of the Ragulator complex. Lamtor1 wraps around Lamtor2–5, stabilizing the Ragulator complex, and the LAMTOR2/3 heterodimer associates with RagA/B and RagC/D GTPases. The original image is from the RCSB PDB (rcsb.org), PDB ID: 6WJ2 (from S. A., Lawrence, R. E., Hurley, J. H. (2020). Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. Nat Struct Mol Biol 27: 1017–1023)