Fig. 1
From: Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy
Epigenetic changes associated with CAR-T-cell differentiation and exhaustion. Epigenetic profiles such as DNA or histone H3K9/K27 methylations are altered during A differentiation of stem cell-like memory T (TSCM) cells into effector memory T (TEM) cells or B T-cell exhaustion. A Transcriptional repression by DNA or histone modification at the promoter/enhancer regions of native T-cell-associated genes (TCF7, SELL, CCR7, and LEF1) by epigenetics factors including DNMT3A, TET2, SUV39H1, and PRDM1. B Expression of exhaustion-associated genes (NR4A1/2/3, HAVCR2, TOX, and LAG3) is also regulated by epigenetic mechanisms such as DNA methylation or histone H3K9/K27 methylation