Fig. 3
From: Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective
TRM in IBD. In IBD, certain subsets of TRM have been implicated in the pathogenesis of IBD. A subset of CD4+ CD103+ TRM, which is increased in Crohn’s disease, becomes activated by cytokines that are abundant in the gut mucosa of IBD patients. These TRM secrete inflammatory cytokines and cytotoxic granules, contributing to the induction of inflammation. In UC, CD8+ TRM with high Eomes expression undergo clonal expansion in the gut mucosa and express high levels of inflammatory cytokines, chemokines, and cytotoxic granules. In contrast, CD39-expressing CD8.+ TRM are reduced in IBD, leading to inflammation triggered by the accumulation of ATP and ADP (figure created by BioRender)