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  1. Pericytes, surrounding the endothelium, fulfill diverse functions that are crucial for vascular homeostasis. The loss of pericytes is associated with pathologies, such as diabetic retinopathy and Alzheimer’s d...

    Authors: Jan Eglinger, Haiko Karsjens and Eckhard Lammert
    Citation: Inflammation and Regeneration 2017 37:2
    Content type: Research article Published on:

  2. Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...

    Authors: Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio and Ikuo Morita
    Citation: Inflammation and Regeneration 2017 37:1
    Content type: Research article Published on:

  3. Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Authors: Takao Ito and Tatsushi Igaki
    Citation: Inflammation and Regeneration 2016 36:25
    Content type: Review Published on:

  4. This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. MSCs show a unique function to modulate immune reaction although the molecular m...

    Authors: Ryo Tamura, Shinji Uemoto and Yasuhiko Tabata
    Citation: Inflammation and Regeneration 2016 36:26
    Content type: Research article Published on:

  5. Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...

    Authors: Seitaro Fujishima
    Citation: Inflammation and Regeneration 2016 36:24
    Content type: Review Published on:

  7. The liver is a unique organ with an extraordinary capacity to regenerate upon various injuries. In acute and transient liver injury by insults such as chemical hepatotoxins, the liver in rodents returns to the...

    Authors: Minoru Tanaka and Atsushi Miyajima
    Citation: Inflammation and Regeneration 2016 36:19
    Content type: Review Published on:

  10. The lungs are the primary organs for respiration, the process by which carbon dioxide and oxygen are exchanged. The alveolus, which is the site of gas exchange in the lungs, consists of multiple cell types inc...

    Authors: Mitsuhiro Yamada, Naoya Fujino and Masakazu Ichinose
    Citation: Inflammation and Regeneration 2016 36:15
    Content type: Review Published on:

  11. The renin-angiotensin system (RAS) plays a potential role in the development of end-organ damage, and tissue RAS activation has been suggested as a risk factor of several diseases including diabetes. So far, u...

    Authors: Atsuhiro Kanda and Susumu Ishida
    Citation: Inflammation and Regeneration 2016 36:22
    Content type: Review Published on:

  12. Age-related loss of the skeletal muscle and its function is known as sarcopenia. Definition and diagnostic criteria for sarcopenia have been outlined as consensus statements from several study groups, includin...

    Authors: Sumito Ogawa, Mitsutaka Yakabe and Masahiro Akishita
    Citation: Inflammation and Regeneration 2016 36:17
    Content type: Review Published on:

  14. Bacterial infections cause an increase in the population of hematopoietic stem cells (HSCs). To investigate the downstream factors associated with hematopoietic stem cells, mice are infected with Mycobacterium av...

    Authors: Atsuko Masumi, Keiko Mochida, Kazuya Takizawa, Takuo Mizukami, Madoka Kuramitsu, Momoka Tsuruhara, Shigetarou Mori, Keigo Shibayama, Kazunari Yamaguchi and Isao Hamaguchi
    Citation: Inflammation and Regeneration 2016 36:21
    Content type: Research article Published on:

  15. Chronological aging is linked to cellular senescence, and there is accumulating evidence for a pathological role of cellular senescence in age-related disorders such as obesity, diabetes, and heart failure. Th...

    Authors: Goro Katsuumi, Ippei Shimizu, Yohko Yoshida and Tohru Minamino
    Citation: Inflammation and Regeneration 2016 36:16
    Content type: Review Published on:

  17. Vascular and cardiac valve calcification is associated with cardiovascular mortality in the general population. Increasing clinical and experimental evidence suggests that inflammation accelerates the progress...

    Authors: Ryo Kawakami, Hironori Nakagami, Takahisa Noma, Koji Ohmori, Masakazu Kohno and Ryuichi Morishita
    Citation: Inflammation and Regeneration 2016 36:10
    Content type: Review Published on:

  19. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been known as a hematopoietic growth factor and immune modulator. Recent studies revealed that GM-CSF also had pro-inflammatory functions and contr...

    Authors: Aoi Shiomi, Takashi Usui and Tsuneyo Mimori
    Citation: Inflammation and Regeneration 2016 36:8
    Content type: Review Published on:

  22. Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding fo...

    Authors: Hideki Arimochi, Yuki Sasaki, Akiko Kitamura and Koji Yasutomo
    Citation: Inflammation and Regeneration 2016 36:13
    Content type: Review Published on:

  23. Within the phospholipase A2 (PLA2) superfamily that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 isoforms in ...

    Authors: Hiroyasu Sato, Yoshitaka Taketomi and Makoto Murakami
    Citation: Inflammation and Regeneration 2016 36:7
    Content type: Review Published on:

  24. Systemic sclerosis is a complex disease that involves “autoimmunity,” “inflammation,” “fibrosis,” and “vasculopathy.” Microvascular damage and dysfunction particularly represent the earliest morphological and ...

    Authors: Satoshi Kubo and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2016 36:5
    Content type: Review Published on:

  25. Osteonecrosis of the femoral head is an intractable disease often occurring in patients aged 30–40 years that can cause femoral head collapse, pain, and gait disturbance. Background factors, including corticos...

    Authors: Yutaka Kuroda, Shuichi Matsuda and Haruhiko Akiyama
    Citation: Inflammation and Regeneration 2016 36:4
    Content type: Review Published on:

  27. Rodent studies have recently demonstrated substantial integration of transplanted photoreceptors, with potential synaptic connection and functional restoration. Consequently, photoreceptor transplantation ther...

    Authors: Hiroshi Shirai and Michiko Mandai
    Citation: Inflammation and Regeneration 2016 36:2
    Content type: Review Published on:


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Inflammation and Regeneration

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