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Table 1 Predictors of fibrostenosing Crohn’s disease

From: Pathogenesis and management of gastrointestinal inflammation and fibrosis: from inflammatory bowel diseases to endoscopic surgery

Clinical Age at diagnosis < 40 years
Perianal disease at diagnosis
Need for steroids during first flare
Early use of azathioprine or anti-TNF
Small bowel disease location
Prior appendectomy
Environmental Smoking
Endoscopic Deep mucosal laceration
Genetic Janus-associated kinase 2 (JAK2)
ATG16L1
NOD2/CARD15 mutations on both chromosomes
TNF superfamily 15 (TNFSF15) in Asians
5T5T in the MMP3 gene
rs1363670
Serological Antimicrobial antibodies
Anti-Saccharomyces cerevisiae (ASCA) IgA in Asians