Conboy IM, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433(7027):760–4.
Article
CAS
PubMed
Google Scholar
Villeda SA, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med. 2014;20(6):659–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Katsimpardi L, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014;344(6184):630–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kiss T, et al. Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood. Geroscience. 2020;42(2):727–48.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gonzalez-Armenta JL, et al. Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice. J Gerontol A Biol Sci Med Sci. 2021;76(3):434–9.
Article
CAS
PubMed
Google Scholar
Villeda SA, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011;477(7362):90–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rebo J, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun. 2016;7:13363.
Article
CAS
PubMed
PubMed Central
Google Scholar
Saenz-Pipaon G, et al. The Role of Circulating Biomarkers in Peripheral Arterial Disease. Int J Mol Sci. 2021:22(7).
O'Neill S, et al. Blood-Based Biomarkers for Metabolic Syndrome. Trends Endocrinol Metab. 2016;27(6):363–74.
Article
CAS
PubMed
Google Scholar
Triposkiadis F, Xanthopoulos A, Butler J. Cardiovascular Aging and Heart Failure JACC Review Topic of the Week. J Am Coll Cardiol. 2019;74(6):804–13.
Article
PubMed
Google Scholar
Anon-Hidalgo J, et al. Circulating GDF11 levels are decreased with age but are unchanged with obesity and type 2 diabetes. Aging (Albany NY). 2019;11(6):1733–44.
Article
CAS
Google Scholar
Loffredo FS, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013;153(4):828–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu HZ, et al. GDF11 Alleviates Pathological Myocardial Remodeling in Diabetic Cardiomyopathy Through SIRT1-Dependent Regulation of Oxidative Stress and Apoptosis. Front Cell Dev Biol. 2021;9.
Garrido-Moreno V, et al. GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication. Pharmacol Res. 2019;146.
Jiao L, et al. GDF11 replenishment protects against hypoxia-mediated apoptosis in cardiomyocytes by regulating autophagy. Eur J Pharmacol. 2020;885.
Johnen H, et al. Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(−/−) mice from the development of atherosclerosis. Cardiovasc Pathol. 2012;21(6):499–505.
Article
CAS
PubMed
Google Scholar
Garbern J, et al. Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice. Am J Phys Heart Circ Phys. 2019;317(1):H201–12.
CAS
Google Scholar
Egerman MA, et al. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab. 2015;22(1):164–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jin Q, et al. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skelet Muscle. 2019;9.
Harper SC, et al. GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death. Circ Res. 2018;123(11):1220–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smith SC, et al. GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy. Circ Res. 2015;117(11):926–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Conte M, et al. GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. Front Immunol. 2020;11.
Tavenier J, et al. Association of GDF15 With Inflammation and Physical Function During Aging and Recovery After Acute Hospitalization: A Longitudinal Study of Older Patients and Age-Matched Controls. J Gerontol A Biol Sci Med Sci. 2021;76(6):964–74.
Article
CAS
PubMed
Google Scholar
Herpich C, et al. Associations Between Serum GDF15 Concentrations, Muscle Mass, and Strength Show Sex-Specific Differences in Older Hospital Patients. Rejuvenation Res. 2021;24(1):14–9.
Article
CAS
PubMed
Google Scholar
Kempf T, et al. Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure. J Am Coll Cardiol. 2007;50(11):1054–60.
Article
CAS
PubMed
Google Scholar
Daniels LB, et al. Growth-Differentiation Factor-15 Is a Robust, Independent Predictor of 11-Year Mortality Risk in Community-Dwelling Older Adults The Rancho Bernardo Study. Circulation. 2011;123(19):2101–10.
Article
PubMed
PubMed Central
Google Scholar
Wallentin, L., et al., Growth Differentiation Factor 15, a Marker of Oxidative Stress and Inflammation, for Risk Assessment in Patients With Atrial Fibrillation Insights From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial. Circulation, 2014. 130(21): p. 1847−+.
Wollert KC, Kempf T, Wallentin L. Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease. Clin Chem. 2017;63(1):140–51.
Article
CAS
PubMed
Google Scholar
Li J, et al. Additional Diagnostic Value of Growth Differentiation Factor-15 (GDF-15) to N-Terminal B-Type Natriuretic Peptide (NT-proBNP) in Patients with Different Stages of Heart Failure. Med Sci Monit. 2018;24:4992–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rochette L, et al. GDF15 and Cardiac Cells: Current Concepts and New Insights. Int J Mol Sci. 2021:22(16).
Kempf T, et al. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res. 2006;98(3):351–60.
Article
CAS
PubMed
Google Scholar
Kempf T, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med. 2011;17(5):581–U101.
Article
CAS
PubMed
Google Scholar
Garfield BE, et al. Growth/differentiation factor 15 causes TGFbeta-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension. Thorax. 2019;74(2):164–76.
Article
PubMed
Google Scholar
Schafer MJ, et al. The senescence-associated secretome as an indicator of age and medical risk. Jci Insight. 2020:5(12).
Park H, et al. GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells. Oncotarget. 2016;7(9):9634–44.
Article
PubMed
PubMed Central
Google Scholar
Sabry M, et al. Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats. PLoS One. 2021;16(2):e0244650.
Article
CAS
PubMed
PubMed Central
Google Scholar
Signorelli SS, et al. Patients with unrecognized peripheral arterial disease (PAD) assessed by ankle-brachial index (ABI) present a defined profile of proinflammatory markers compared to healthy subjects. Cytokine. 2012;59(2):294–8.
Article
CAS
PubMed
Google Scholar
Signorelli SS, et al. Plasma Levels of Inflammatory Biomarkers in Peripheral Arterial Disease: Results of a Cohort Study. Angiology. 2016;67(9):870–4.
Article
CAS
PubMed
Google Scholar
Pasterkamp G, et al. Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery. Atherosclerosis. 2000;150(2):245–53.
Article
CAS
PubMed
Google Scholar
Wang C, et al. Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway. Int J Biochem Cell Biol. 2015;69:173–82.
Article
CAS
PubMed
Google Scholar
Kuzuya M, et al. Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26(5):1120–5.
Article
CAS
PubMed
Google Scholar
Luttun A, et al. Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth. Circulation. 2004;109(11):1408–14.
Article
CAS
PubMed
Google Scholar
Zeng B, et al. Elevated circulating levels of matrix metalloproteinase-9 and-2 in patients with symptomatic coronary artery disease. Intern Med J. 2005;35(6):331–5.
Article
CAS
PubMed
Google Scholar
Tayebjee MH, et al. Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity. J Intern Med. 2005;257(1):110–6.
Article
CAS
PubMed
Google Scholar
Takagi H, et al. Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis. Interact Cardiovasc Thorac Surg. 2009;9(3):437–40.
Article
PubMed
Google Scholar
Vianello E, et al. Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, −2, 9 and TIMP-1 circulating levels in elderly patients. Immun Ageing. 2016;13:9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Komosinska-Vassev K, et al. Age- and Gender-Dependent Changes in Connective Tissue Remodeling: Physiological Differences in Circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 Level. Gerontology. 2011;57(1):44–52.
Article
CAS
PubMed
Google Scholar
Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020:21(24).
Kaur N, et al. Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response. Front Physiol. 2021;12:694864.
Article
PubMed
PubMed Central
Google Scholar
Hanna A, Frangogiannis NG. Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure. Cardiovasc Drugs Ther. 2020;34(6):849–63.
Article
CAS
PubMed
Google Scholar
Rybtsova N, et al. Can Blood-Circulating Factors Unveil and Delay Your Biological Aging? Biomedicines. 2020;8(12).
Alvarez-Rodriguez L, et al. Aging is associated with circulating cytokine dysregulation. Cell Immunol. 2012;273(2):124–32.
Article
CAS
PubMed
Google Scholar
Kumric M, et al. Circulating Biomarkers Reflecting Destabilization Mechanisms of Coronary Artery Plaques: Are We Looking for the Impossible? Biomolecules. 2021;11(6).
Saenz-Pipaon G, et al. Functional and transcriptomic analysis of extracellular vesicles identifies calprotectin as a new prognostic marker in peripheral arterial disease (PAD). J Extracell Vesicles. 2020;9(1):1729646.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moutachakkir M, et al. Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. Ann Biol Clin (Paris). 2017;75(2):225–9.
Google Scholar
Norja S, et al. C-reactive protein in vulnerable coronary plaques. J Clin Pathol. 2007;60(5):545–8.
Article
CAS
PubMed
Google Scholar
Noren Hooten N, et al. Association of oxidative DNA damage and C-reactive protein in women at risk for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2012;32(11):2776–84.
Article
PubMed
Google Scholar
Liu Y, et al. Study on the interaction mechanism between C-reactive protein and platelets in the development of acute myocardial infarction. Ann Transl Med. 2021;9(12):1012.
Article
CAS
PubMed
PubMed Central
Google Scholar
Akkoca M, et al. Role of microcirculatory function and plasma biomarkers in determining the development of cardiovascular adverse events in patients with peripheral arterial disease: a 5-year follow-up. Anatol J Cardiol. 2018;20(4):220–8.
CAS
PubMed
PubMed Central
Google Scholar
Ridker PM. From C-reactive protein to interleukin-6 to interleukin-1 moving upstream to identify novel targets for atheroprotection. Circ Res. 2016;118(1):145–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang B, et al. Interleukin-6 as a predictor of the risk of cardiovascular disease: a meta-analysis of prospective epidemiological studies. Immunol Investig. 2018;47(7):689–99.
Article
CAS
Google Scholar
Sarwar N, et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet. 2012;379(9822):1205–13.
Article
PubMed
Google Scholar
Edsfeldt A, et al. Circulating cytokines reflect the expression of pro-inflammatory cytokines in atherosclerotic plaques. Atherosclerosis. 2015;241(2):443–9.
Article
CAS
PubMed
Google Scholar
Ridker PM, et al. Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation. 2000;101(18):2149–53.
Article
CAS
PubMed
Google Scholar
Dunlay SM, et al. Tumor necrosis factor-alpha and mortality in heart failure: a community study. Circulation. 2008;118(6):625–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mattila P, et al. TNF alpha-induced expression of endothelial adhesion molecules, ICAM-1 and VCAM-1, is linked to protein kinase C activation. Scand J Immunol. 1992;36(2):159–65.
Article
CAS
PubMed
Google Scholar
Mark KS, Trickler WJ, Miller DW. Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. J Pharmacol Exp Ther. 2001;297(3):1051–8.
CAS
PubMed
Google Scholar
Rask-Madsen C, et al. Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation. 2003;108(15):1815–21.
Article
CAS
PubMed
Google Scholar
Moe GW, et al. In vivo TNF-alpha inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure. Am J Physiol Heart Circ Physiol. 2004;287(4):H1813–20.
Article
CAS
PubMed
Google Scholar
Bissonnette R, et al. Effects of the tumor necrosis factor-alpha antagonist adalimumab on arterial inflammation assessed by positron emission tomography in patients with psoriasis: results of a randomized controlled trial. Circ Cardiovasc Imaging. 2013;6(1):83–90.
Article
PubMed
Google Scholar
Pina T, et al. Anti-tumor necrosis factor-alpha therapy improves endothelial function and arterial stiffness in patients with moderate to severe psoriasis: a 6-month prospective study. J Dermatol. 2016;43(11):1267–72.
Article
CAS
PubMed
Google Scholar
Hurlimann D, et al. Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. Circulation. 2002;106(17):2184–7.
Article
PubMed
Google Scholar
Chung ES, et al. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation. 2003;107(25):3133–40.
Article
CAS
PubMed
Google Scholar
Ridker PM, et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 2017;377(12):1119–31.
Article
CAS
PubMed
Google Scholar
Everett BM, et al. Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure. Circulation. 2019;139(10):1289–99.
Article
CAS
PubMed
Google Scholar
Ridker PM, et al. Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1 beta inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis. Eur Heart J. 2020;41(23):2153–63.
Article
CAS
PubMed
Google Scholar
Morisaki N, et al. New indices of ischemic heart disease and aging: Studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis. 1997;131(1):43–8.
Article
CAS
PubMed
Google Scholar
Edlinger C, et al. Disease-specific characteristics of vascular cell adhesion molecule-1 levels in patients with peripheral artery disease. Heart Vessel. 2019;34(6):976–83.
Article
Google Scholar
Blann AD, et al. Circulating ICAM-1 and VCAM-1 in peripheral artery disease and hypercholesterolaemia: relationship to the location of atherosclerotic disease, smoking, and in the prediction of adverse events. Thromb Haemost. 1998;79(6):1080–5.
Article
CAS
PubMed
Google Scholar
Pradhan AD, Rifai N, Ridker PM. Soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and the development of symptomatic peripheral arterial disease in men. Circulation. 2002;106(7):820–5.
Article
CAS
PubMed
Google Scholar
Lin QY, et al. Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1(+) monocytes. Am J Phys Heart Circ Phys. 2019;317(6):H1301–11.
CAS
Google Scholar
Karnik SS, et al. International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli [corrected]. Pharmacol Rev. 2015;67(4):754–819.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang MY, Shah AM. Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries. J Mol Cell Cardiol. 2015;83:101–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aroor AR, et al. The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol (Lausanne). 2013;4:161.
Article
Google Scholar
Ferder L, et al. Biomolecular changes in the aging myocardium - the effect of enalapril. Am J Hypertens. 1998;11(11):1297–304.
Article
CAS
PubMed
Google Scholar
Benigni A, et al. Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. Age. 2013;35(3):993–1005.
Article
CAS
PubMed
Google Scholar
Campbell DJ, et al. Angiotensin peptides in spontaneously hypertensive and normotensive Donryu rats. Hypertension. 1995;25(5):928–34.
Article
CAS
PubMed
Google Scholar
Duggan J, et al. Effects of aging and hypertension on plasma angiotensin-Ii and platelet angiotensin-Il receptor density. Am J Hypertens. 1992;5(10):687–93.
Article
CAS
PubMed
Google Scholar
Li J, et al. An overview of osteocalcin progress. J Bone Miner Metab. 2016;34(4):367–79.
Article
CAS
PubMed
Google Scholar
Zoch ML, Clemens TL, Riddle RC. New insights into the biology of osteocalcin. Bone. 2016;82:42–9.
Article
CAS
PubMed
Google Scholar
Jung KY, et al. Age- and sex-specific association of circulating osteocalcin with dynamic measures of glucose homeostasis. Osteoporos Int. 2016;27(3):1021–9.
Article
CAS
PubMed
Google Scholar
Seidu S, Kunutsor SK, Khunti K. Association of circulating osteocalcin with cardiovascular disease and intermediate cardiovascular phenotypes: systematic review and meta-analysis. Scand Cardiovasc J. 2019;53(6):286–95.
Article
CAS
PubMed
Google Scholar
Kanazawa I, et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2009;94(1):45–9.
Article
CAS
PubMed
Google Scholar
Kim HL, Kim SH. Pulse wave velocity in atherosclerosis. Front Cardiovasc Med. 2019;6:41.
Article
PubMed
PubMed Central
Google Scholar
Khrimian L, et al. Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med. 2017;214(10):2859–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mera P, et al. Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab. 2016;23(6):1078–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mera P, et al. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice. Molecular Metabolism. 2016;5(10):1042–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Smith C, et al. Osteocalcin and its forms across the lifespan in adult men. Bone. 2020;130.
Dirckx N, et al. The role of osteoblasts in energy homeostasis. Nat Rev Endocrinol. 2019;15(11):651–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
De Toni L, et al. Osteocalcin: a protein hormone connecting metabolism, bone and testis function. Protein Pept Lett. 2020;27(12):1268–75.
Article
PubMed
Google Scholar
Sadek NB, et al. The potential role of undercarboxylated osteocalcin upregulation in microvascular insufficiency in a rat model of diabetic cardiomyopathy. J Cardiovasc Pharmacol Ther. 2020;25(1):86–97.
Article
CAS
PubMed
Google Scholar
Diegel CR, et al. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020;16(5):e1008361.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moriishi T, et al. Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLoS Genet. 2020;16(5):e1008586.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tacey A, et al. Association between circulating osteocalcin and cardiometabolic risk factors following a 4-week leafy green vitamin K-rich diet. Ann Nutr Metab. 2020;76(5):361–7.
Article
CAS
PubMed
Google Scholar
Liu ZX, et al. Serum Metrnl is associated with the presence and severity of coronary artery disease. J Cell Mol Med. 2019;23(1):271–80.
Article
CAS
PubMed
Google Scholar
Wang K, et al. Serum levels of Meteorin-like (Metrnl) are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance. Med Sci Monit. 2019;25:2337–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chung HS, et al. Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes. Diabetes Res Clin Pract. 2018;136:100–7.
Article
CAS
PubMed
Google Scholar
El-Ashmawy HM, et al. Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis. Diabetes Res Clin Pract. 2019;150:57–63.
Article
CAS
PubMed
Google Scholar
AlKhairi I, et al. Increased expression of Meteorin-like hormone in type 2 diabetes and obesity and its association with irisin. Cells. 2019:8(10).
Lee JH, et al. Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes. Diabetes Res Clin Pract. 2018;135:7–10.
Article
CAS
PubMed
Google Scholar
Zheng SL, et al. Evaluation of two commercial enzyme-linked immunosorbent assay kits for the detection of human circulating Metrnl. Chem Pharm Bull (Tokyo). 2018;66(4):391–8.
Article
CAS
Google Scholar
Wu Q, et al. Circulating Meteorin-like levels in patients with type 2 diabetes mellitus: a meta-analysis. Curr Pharm Des. 2020;26(44):5732–8.
Article
CAS
PubMed
Google Scholar
Rao RR, et al. Meteorin-like Is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014;157(6):1279–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lee JO, et al. The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK alpha 2. FEBS J. 2020;287(10):2087–104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qi Q, et al. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride. Acta Pharmacol Sin. 2020;41(12):1568–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu C, et al. Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway. Redox Biol. 2020;37.
Hu W, Wang R, Sun B. Meteorin-like ameliorates beta cell function by inhibiting beta cell apoptosis of and promoting beta cell proliferation via activating the WNT/beta-catenin pathway. Front Pharmacol. 2021;12:627147.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baht GS, et al. Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism (vol 2, pg 278, 2020). Nature Metabolism. 2020;2(8):794.
Article
PubMed
Google Scholar
Sousa-Victor P, et al. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism. 2019;1(2):276–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu T, et al. Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. J Exp Med. 2021:218(6).
Lindahl M, et al. MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep. 2014;7(2):366–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hakonen E, et al. MANF protects human pancreatic beta cells against stress-induced cell death. Diabetologia. 2018;61(10):2202–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu WL, et al. Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against neuronal apoptosis via activation of Akt/MDM2/p53 signaling pathway in a rat model of intracerebral hemorrhage. Front Mol Neurosci. 2018;11.
Tadimalla A, et al. Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart. Circ Res. 2008;103(11):1249–58.
Article
CAS
PubMed
PubMed Central
Google Scholar
Arrieta A, et al. Mesencephalic astrocyte?derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart. J Biol Chem. 2020;295(22):7566–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shen Y, et al. Serum FGF21 Is Associated with future cardiovascular events in patients with coronary artery disease. Cardiology. 2018;139(4):212–8.
Article
CAS
PubMed
Google Scholar
Li HT, et al. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol. 2010;53(5):934–40.
Article
CAS
PubMed
Google Scholar
Hanks LJ, et al. Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals. J Clin Transl Endocrinol. 2015;2(2):77–82.
PubMed
PubMed Central
Google Scholar
Taniguchi H, et al. Endurance exercise reduces hepatic fat content and serum fibroblast growth factor 21 levels in elderly men. J Clin Endocrinol Metab. 2016;101(1):190–7.
Article
Google Scholar
Sanchis-Gomar F, et al. A preliminary candidate approach identifies the combination of chemerin, fetuin-A, and fibroblast growth factors 19 and 21 as a potential biomarker panel of successful aging. Age. 2015:37(3).
Villarroya J, et al. Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue. Aging Cell. 2018:17(5).
Kharitonenkov A, et al. FGF-21 as a novel metabolic regulator. J Clin Investig. 2005;115(6):1627–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Coskun T, et al. Fibroblast Growth Factor 21 Corrects obesity in mice. Endocrinology. 2008;149(12):6018–27.
Article
CAS
PubMed
Google Scholar
Zhang Y, et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife. 2012;1.
Fang H, et al. FGF21 prevents low-protein diet-induced renal inflammation in aged mice. Am J Physiol Renal Physiol. 2021;321(3):F356–68.
Article
CAS
PubMed
Google Scholar
Kuroda M, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127(9):3496–509.
Article
PubMed
PubMed Central
Google Scholar
Charles ED, et al. Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study. Obesity. 2019;27(1):41–9.
Article
CAS
PubMed
Google Scholar
Gaich G, et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 2013;18(3):333–40.
Article
CAS
PubMed
Google Scholar
Dong JQ, et al. Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study. Br J Clin Pharmacol. 2015;80(5):1051–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baccarelli A, et al. Activin A serum levels and aging of the pituitary-gonadal axis: a cross-sectional study in middle-aged and elderly healthy subjects. Exp Gerontol. 2001;36(8):1403–12.
Article
CAS
PubMed
Google Scholar
Peng LN, et al. Association between serum activin A and metabolic syndrome in older adults: potential of activin A as a biomarker of cardiometabolic disease. Exp Gerontol. 2018;111:197–202.
Article
CAS
PubMed
Google Scholar
Kuo CS, et al. Increased activin A levels in prediabetes and association with carotid intima-media thickness: a cross-sectional analysis from I-Lan Longitudinal Aging Study. Sci Rep. 2018;8.
Bian XH, et al. Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy. BMJ Open Diabetes Res Care. 2019:7(1).
Polyzos SA, et al. Activin A and follistatin in patients with nonalcoholic fatty liver disease. Metabolism. 2016;65(10):1550–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roh JD, et al. Activin type II receptor signaling in cardiac aging and heart failure. Sci Transl Med. 2019:11(482).
Vanhoutte F, et al. Pharmacokinetics and pharmacodynamics of garetosmab (anti-activin A): results from a first-in-human phase 1 study. J Clin Pharmacol. 2020;60(11):1424–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Muller DC, et al. Insulin response during the oral glucose tolerance test: the role of age, sex, body fat and the pattern of fat distribution. Aging (Milano). 1996;8(1):13–21.
CAS
Google Scholar
Chang AM, Halter JB. Aging and insulin secretion. Am J Physiol Endocrinol Metab. 2003;284(1):E7–E12.
Article
CAS
PubMed
Google Scholar
Templeman NM, et al. Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. Cell Rep. 2017;20(2):451–63.
Article
CAS
PubMed
Google Scholar
Belke DD, et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Investig. 2002;109(5):629–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shimizu I, et al. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Investig. 2010;120(5):1506–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shimizu I, et al. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab. 2012;15(1):51–64.
Article
CAS
PubMed
Google Scholar
Hua YN, et al. Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res Cardiol. 2011;106(6):1173–91.
Article
CAS
PubMed
Google Scholar
Shimizu I, Minamino T. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016;97:245–62.
Article
CAS
PubMed
Google Scholar
Packer M. Potentiation of insulin signaling contributes to heart failure in type 2 diabetes: a hypothesis supported by both mechanistic studies and clinical trials. JACC Basic Transl Sci. 2018;3(3):415–9.
Article
PubMed
PubMed Central
Google Scholar
Juul A, et al. Serum insulin-like growth factor-I in 1030 healthy-children, adolescents, and adults - relation to age, sex, stage of puberty, testicular size, and body-mass index. J Clin Endocrinol Metab. 1994;78(3):744–52.
CAS
PubMed
Google Scholar
Zhang WB, et al. Insulin-like growth factor-1 and IGF binding proteins predict all-cause mortality and morbidity in older adults. Cells. 2020:9(6).
Toth P, et al. IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell. 2015;14(6):1034–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bailey-Downs LC, et al. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012;67(4):313–29.
Article
PubMed
Google Scholar
Xu XH, Hueckstaedt LK, Ren J. Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy. J Hepatol. 2013;59(2):308–17.
Article
CAS
PubMed
Google Scholar
Holzenberger M, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421(6919):182–7.
Article
CAS
PubMed
Google Scholar
Shiojima I, et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Investig. 2005;115(8):2108–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Izumiya Y, et al. Fast/glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008;7(2):159–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xia J, et al. Correlation of increased plasma osteoprotegerin and cardiovascular risk factors in patients with adult growth hormone deficiency. Int J Clin Exp Med. 2015;8(3):3184–92.
PubMed
PubMed Central
Google Scholar
Colao A, et al. Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab. 2001;86(5):1874–81.
CAS
PubMed
Google Scholar
Molitch ME, et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(6):1587–609.
Article
CAS
PubMed
Google Scholar
Lange KHW, et al. GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. J Clin Endocrinol Metab. 2002;87(2):513–23.
Article
CAS
PubMed
Google Scholar
Blackman MB, et al. Growth hormone and sex steroid administration in healthy aged women and men - a randomized controlled trial. JAMA. 2002;288(18):2282–92.
Article
CAS
PubMed
Google Scholar
Marcus R, et al. Effects of short-term administration of recombinant human growth-hormone to elderly people. J Clin Endocrinol Metab. 1990;70(2):519–27.
Article
CAS
PubMed
Google Scholar
Papadakis MA, et al. Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med. 1996;124(8):708.
Article
CAS
PubMed
Google Scholar
Harman SM, Blackman MR. Use of growth hormone for prevention or treatment of effects of aging. J Gerontol A Biol Sci Med Sci. 2004;59(7):652–8.
Article
PubMed
Google Scholar
Swerdlow AJ, et al. Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet. 2002;360(9329):273–7.
Article
CAS
PubMed
Google Scholar
Perls TT, Reisman NR, Olshansky SJ. Provision or distribution of growth hormone for "antiaging": clinical and legal issues. JAMA. 2005;294(16):2086–90.
Article
CAS
PubMed
Google Scholar
Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81(2):629–83.
Article
CAS
PubMed
Google Scholar
Plasencia G, et al. Plasma oxytocin and vasopressin levels in young and older men and women: functional relationships with attachment and cognition. Psychoneuroendocrinology. 2019;110.
Kunitake Y, et al. Serum oxytocin levels and logical memory in older people in rural Japan. J Geriatr Psychiatry Neurol. 2021;34(2):156–61.
Article
PubMed
Google Scholar
Elabd C, et al. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nat Commun. 2014;5.
Zhang H, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PLoS One. 2013:8(6).
Luo, D., et al., Oxytocin promotes hepatic regeneration in elderly mice. Iscience, 2021. 24(2).
Barraza JA, et al. Effects of a 10-Day oxytocin trial in older adults on health and well-being. Exp Clin Psychopharmacol. 2013;21(2):85–92.
Article
CAS
PubMed
Google Scholar
Svartberg J, et al. The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. Eur J Endocrinol. 2003;149(2):145–52.
Article
CAS
PubMed
Google Scholar
Barrettconnor E, Khaw KT. Endogenous sex-hormones and cardiovascular-disease in men - a prospective population-based study. Circulation. 1988;78(3):539–45.
Article
CAS
Google Scholar
Khaw KT, et al. Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) prospective population study. Circulation. 2007;116(23):2694–701.
Article
CAS
PubMed
Google Scholar
Smith GD, et al. Cortisol, testosterone, and coronary heart disease - prospective evidence from the Caerphilly study. Circulation. 2005;112(3):332–40.
Article
CAS
PubMed
Google Scholar
Jankowska EA, et al. Anabolic deficiency in men with chronic heart failure - prevalence and detrimental impact on survival. Circulation. 2006;114(17):1829–37.
Article
CAS
PubMed
Google Scholar
Oh JY, et al. Endogenous sex hormones predict the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes. 2001;50:A75–6.
Google Scholar
Baillargeon and Mansi, Trends in androgen prescribing in the United States, 2001 to 2011 (vol 173, pg 1465, 2013). JAMA 173(15): p. 1477–1477.
Budoff MJ, et al. Testosterone treatment and coronary artery plaque volume in older men with low testosterone. JAMA. 2017;317(7):708–16.
Article
CAS
PubMed
PubMed Central
Google Scholar
Basaria S, et al. Adverse events associated with testosterone administration. N Engl J Med. 2010;363(2):109–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Navarro-Penalver M, et al. Testosterone replacement therapy in deficient patients with chronic heart failure: a randomized double-blind controlled pilot study. J Cardiovasc Pharmacol Ther. 2018;23(6):543–50.
Article
CAS
PubMed
Google Scholar
Malkin CJ, et al. Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J. 2006;27(1):57–64.
Article
CAS
PubMed
Google Scholar
Resnick SM, et al. Testosterone treatment and cognitive function in older men with low testosterone and age-associated memory impairment. JAMA. 2017;317(7):717–27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Snyder PJ, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Storer TW, et al. Effects of testosterone supplementation for 3 years on muscle performance and physical function in older men. J Clin Endocrinol Metab. 2017;102(2):583–93.
PubMed
Google Scholar
Walsh JP, Kitchens AC. Testosterone therapy and cardiovascular risk. Trends Cardiovasc Med. 2015;25(3):250–7.
Article
CAS
PubMed
Google Scholar
MacDonell SO, et al. Vitamin D status and its predictors in New Zealand aged-care residents eligible for a government-funded universal vitamin D supplementation programme. Public Health Nutr. 2016;19(18):3349–60.
Article
PubMed
Google Scholar
Ginde AA, et al. High-dose monthly vitamin D for Prevention of acute respiratory infection in older long-term care residents: a randomized clinical trial. J Am Geriatr Soc. 2017;65(3):496–503.
Article
PubMed
Google Scholar
Anderson JL, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010;106(7):963–8.
Article
CAS
PubMed
Google Scholar
Seker T, et al. Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients. Anatol J Cardiol. 2015;15(9):744–50.
Article
CAS
PubMed
Google Scholar
Polat V, et al. Low vitamin D status associated with dilated cardiomyopathy. Int J Clin Exp Med. 2015;8(1):1356–62.
PubMed
PubMed Central
Google Scholar
Chen S, et al. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011;124(17):1838–47.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pittas AG, et al. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med. 2019;381(6):520–30.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bischoff-Ferrari HA, et al. Effect of vitamin D supplementation, omega-3 fatty acid supplementation, or a strength-training exercise program on clinical outcomes in older adults the DO-HEALTH randomized clinical trial. JAMA. 2020;324(18):1855–68.
Article
CAS
PubMed
PubMed Central
Google Scholar
Levis S, Gomez-Marin O. Vitamin D and physical function in sedentary older men. J Am Geriatr Soc. 2017;65(2):323–31.
Article
PubMed
Google Scholar
Bischoff-Ferrari HA, et al. Monthly high-dose vitamin D treatment for the prevention of functional decline a randomized clinical trial. JAMA Intern Med. 2016;176(2):175–83.
Article
PubMed
Google Scholar
Witham MD, et al. Vitamin D therapy to reduce blood pressure and left ventricular hypertrophy in resistant hypertension randomized, controlled trial. Hypertension. 2014;63(4):706–12.
Article
CAS
PubMed
Google Scholar
Shea MK, et al. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts. Am J Clin Nutr. 2020;111(6):1170–7.
Article
PubMed
PubMed Central
Google Scholar
Shea MK, et al. Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC). J Nutr. 2017;147(5):888–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shea MK, et al. Vitamin K, circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr. 2008;88(2):356–63.
Article
CAS
PubMed
Google Scholar
Shea MK, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008;167(3):313–20.
Article
PubMed
Google Scholar
Shea MK, et al. Associations between vitamin K status and haemostatic and inflammatory biomarkers in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Thromb Haemost. 2014;112(3):438–44.
CAS
PubMed
PubMed Central
Google Scholar
Zwakenberg SR, et al. Circulating Phylloquinone concentrations and risk of type 2 diabetes: a Mendelian randomization study. Diabetes. 2019;68(1):220–5.
Article
CAS
PubMed
Google Scholar
Lees JS, et al. Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart. 2019;105(12):938–45.
CAS
PubMed
Google Scholar
Brandenburg VM, et al. Slower progress of aortic valve calcification with vitamin K supplementation results from a prospective interventional proof-of-concept study. Circulation. 2017;135(21):2081–3.
Article
PubMed
Google Scholar
Beulens JWJ, et al. Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care. 2010;33(8):1699–705.
Article
CAS
PubMed
PubMed Central
Google Scholar
Witham MD, et al. Vitamin K supplementation to improve vascular stiffness in CKD: the K4Kidneys randomized controlled trial. J Am Soc Nephrol. 2020;31(10):2434–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bartstra JW, et al. Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2. Eur J Nutr. 2021;60(3):1691–9.
Article
CAS
PubMed
Google Scholar
Westerman K, et al. Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitamin K1) supplementation. Epigenetics. 2020;15(8):859–70.
Article
PubMed
PubMed Central
Google Scholar
Olivieri F, et al. Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells. Aging-Us. 2014;6(9):771–87.
Article
Google Scholar
Li P, et al. 17beta-Estradiol enhances vascular endothelial Ets-1/miR-126-3p expression: the possible mechanism for attenuation of atherosclerosis. J Clin Endocrinol Metab. 2017;102(2):594–603.
Article
PubMed
Google Scholar
Zeng P, et al. ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway. Theranostics. 2021;11(3):1129–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ameling S, et al. Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study. BMC Med Genet. 2015;8.
Luo M, et al. Circulating miR-30c as a predictive biomarker of type 2 diabetes mellitus with coronary heart disease by regulating PAI-1/VN interactions. Life Sci. 2019;239.
Olivieri F, et al. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech Ageing Dev. 2012;133(11–12):675–85.
Article
CAS
PubMed
Google Scholar
Mori MA, et al. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Olivieri F, et al. Circulating miRNAs and miRNA shuttles as biomarkers: perspective trajectories of healthy and unhealthy aging. Mech Ageing Dev. 2017;165:162–70.
Article
CAS
Google Scholar
Sha SJ, et al. Safety, tolerability, and feasibility of young plasma infusion in the Plasma for Alzheimer Symptom Amelioration Study: a randomized clinical trial. JAMA Neurol. 2019;76(1):35–40.
Article
PubMed
Google Scholar
Pandika M. Looking to young blood to treat the diseases of aging. ACS Cent Sci. 2019;5(9):1481–4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ikegami R, et al. Metabolomic analysis in heart failure. Circ J. 2018;82(1):10–6.
Article
CAS
Google Scholar
Yeri A, et al. Metabolite profiles of healthy aging index are associated with cardiovascular disease in African Americans: the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2019;74(1):68–72.
Article
CAS
PubMed
Google Scholar
Ho, T.T., et al., Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. J Exp Med, 2021. 218(7).
Ambrosi, T.H., et al., Aged skeletal stem cells generate an inflammatory degenerative niche. Nature, 2021. 597(7875): p. 256−+.