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  1. Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injure...

    Authors: Hidetoshi Masumoto and Jun K. Yamashita
    Citation: Inflammation and Regeneration 2018 38:26
    Content type: Review Published on:

  5. Morphological change in endothelial cells is an initial and crucial step in the process of establishing a functional vascular network. Following or associated with differentiation and proliferation, endothelia...

    Authors: Kiyomi Tsuji-Tamura and Minetaro Ogawa
    Citation: Inflammation and Regeneration 2018 38:25
    Content type: Review Published on:

  7. Atherosclerosis and inflammation are more common in patients with diabetes than in patients without diabetes, and atherosclerosis progression contributes to inflammation. Therefore, anti-inflammatory therapy i...

    Authors: Shiho Yamadera, Yuya Nakamura, Masahiro Inagaki, Sachiyo Kenmotsu, Tetsuhito Nohara, Naoki Sato, Tatsunori Oguchi, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh, Yoshikazu Goto, Akihiko Yura, Yuji Kiuchi and Shinichi Iwai
    Citation: Inflammation and Regeneration 2018 38:13
    Content type: Research article Published on:

  8. Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli and lead to kidney fibrosis. Connective tissue g...

    Authors: Naohiro Toda, Masashi Mukoyama, Motoko Yanagita and Hideki Yokoi
    Citation: Inflammation and Regeneration 2018 38:14
    Content type: Review Published on:

  9. Cysts of the salivary glands are common lesions that occur in the context of various etiologies. Although the diagnostic importance of cysts in salivary gland diseases has been well studied, molecular mechanis...

    Authors: Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2018 38:12
    Content type: Case report Published on:

  11. Zoledronic acid (Zol), one of the bisphosphonates, is frequently utilized for the treatment of osteoporosis and bone metastasis. However, the onset of medication-related osteonecrosis of the jaw (MRONJ) follow...

    Authors: Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga and Tatsuji Nishihara
    Citation: Inflammation and Regeneration 2018 38:16
    Content type: Research article Published on:

  12. Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic i...

    Authors: Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo, Tomomi Ichikawa and Toshinori Nakayama
    Citation: Inflammation and Regeneration 2018 38:10
    Content type: Review Published on:

  13. Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic approach for geriatric disorders. The molecular mechanisms underlying age-related dysfunctions of specific types of a...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Hirotaka Kito, Aoi Matsubara, Mizuki Kaneda, Yu Katsuyama and Hayato Naka-Kaneda
    Citation: Inflammation and Regeneration 2018 38:9
    Content type: Review Published on:

  14. Periodontal diseases are chronic infectious disease in which the pathogenic bacteria initiate the host immune response leading to the destruction of tooth supporting tissue and eventually result in the tooth l...

    Authors: Gurjeet Kaur, Vishakha Grover, Nandini Bhaskar, Rose Kanwaljeet Kaur and Ashish Jain
    Citation: Inflammation and Regeneration 2018 38:8
    Content type: Review Published on:

  15. Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is ...

    Authors: Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka and Shuichi Matsuda
    Citation: Inflammation and Regeneration 2018 38:7
    Content type: Review Published on:

  16. Sjögren’s syndrome (SS) is a chronic inflammatory autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, especially the salivary and lacrimal glands. As a result of salivary gland...

    Authors: Naoto Azuma, Yoshinori Katada and Hajime Sano
    Citation: Inflammation and Regeneration 2018 38:6
    Content type: Review Published on:

  17. The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maint...

    Authors: Ryu Okumura and Kiyoshi Takeda
    Citation: Inflammation and Regeneration 2018 38:5
    Content type: Review Published on:

  19. Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of melanoma patients who showed objective responses to PD-1 blocka...

    Authors: Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2018 38:3
    Content type: Case report Published on:

  21. MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyos...

    Authors: Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura and Iwao Sekigawa
    Citation: Inflammation and Regeneration 2018 38:1
    Content type: Research article Published on:

  23. We previously reported that the mouse Ly6/Plaur domain containing 8 (mLypd8), a GPI-anchored protein highly and selectively expressed on colonic epithelia, contributes to segregation of intestinal microbiota a...

    Authors: Chiao-Ching Hsu, Ryu Okumura and Kiyoshi Takeda
    Citation: Inflammation and Regeneration 2017 37:23
    Content type: Research article Published on:

  25. Abatacept, a CTLA4-Ig fusion protein attenuates T cell activation by inhibiting the CD80/86-CD28 costimulatory pathway that is required for the proper T cell activation and thus displays beneficial effects in ...

    Authors: Toshihiro Tono, Satoko Aihara, Takayuki Hoshiyama, Yoshiyuki Arinuma, Tatsuo Nagai and Shunsei Hirohata
    Citation: Inflammation and Regeneration 2017 37:24
    Content type: Research article Published on:

  26. We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However...

    Authors: Miki Maehara, Masato Sato, Eriko Toyoda, Takumi Takahashi, Eri Okada, Tomomi Kotoku and Masahiko Watanabe
    Citation: Inflammation and Regeneration 2017 37:22
    Content type: Research article Published on:

  27. We recently developed novel cell transplantation method “cell transfer technology” utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patter...

    Authors: Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi and Ikuo Morita
    Citation: Inflammation and Regeneration 2017 37:21
    Content type: Review Published on:

  28. Short-lived reactive nitrogen species and reactive oxygen species have acquired significant attention in the field of biomedical science. Nitric oxide (NO), which was thought to be an unstable gas and pollutan...

    Authors: Sandesh Panthi and Kripa Gautam
    Citation: Inflammation and Regeneration 2017 37:20
    Content type: Review Published on:

    The Correction to this article has been published in Inflammation and Regeneration 2019 39:1

  30. In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MS...

    Authors: Aya Fujishiro, Yasuo Miura, Masaki Iwasa, Sumie Fujii, Noriko Sugino, Akira Andoh, Hideyo Hirai, Taira Maekawa and Tatsuo Ichinohe
    Citation: Inflammation and Regeneration 2017 37:19
    Content type: Research article Published on:

  32. Bone is a metabolically active organ that undergoes continuous remodeling throughout life. However, many complex skeletal defects such as large traumatic bone defects or extensive bone loss after tumor resecti...

    Authors: Pornkawee Charoenlarp, Arun Kumar Rajendran and Sachiko Iseki
    Citation: Inflammation and Regeneration 2017 37:10
    Content type: Review Published on:

  33. Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair; however, these responses often result in extensive fibrotic remodeling with impaired systolic function. Recent reports...

    Authors: Hironori Hara, Norifumi Takeda and Issei Komuro
    Citation: Inflammation and Regeneration 2017 37:13
    Content type: Review Published on:

  34. Regulation of blood vessel permeability is essential for the homeostasis of peripheral tissues. This regulation controls the trafficking of plasma contents, including water, vitamins, ions, hormones, cytokines...

    Authors: Sachiko Ono, Gyohei Egawa and Kenji Kabashima
    Citation: Inflammation and Regeneration 2017 37:11
    Content type: Review Published on:

  35. Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functi...

    Authors: Atsunori Tsuchiya, Yuichi Kojima, Shunzo Ikarashi, Satoshi Seino, Yusuke Watanabe, Yuzo Kawata and Shuji Terai
    Citation: Inflammation and Regeneration 2017 37:16
    Content type: Review Published on:

  37. Atopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. Extensive recent studies ha...

    Authors: Pawinee Rerknimitr, Atsushi Otsuka, Chisa Nakashima and Kenji Kabashima
    Citation: Inflammation and Regeneration 2017 37:14
    Content type: Review Published on:

  38. The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply to many cancers, including liver cancer. Identifica...

    Authors: Kenly Wuputra, Chang-Shen Lin, Ming-Ho Tsai, Chia-Chen Ku, Wen-Hsin Lin, Ya-Han Yang, Kung-Kai Kuo and Kazunari K. Yokoyama
    Citation: Inflammation and Regeneration 2017 37:15
    Content type: Review Published on:

  39. The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial ro...

    Authors: Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata and Junya Masumoto
    Citation: Inflammation and Regeneration 2017 37:9
    Content type: Review Published on:

  40. Dental pulp stem cells/progenitor cells (DPSCs) can be easily obtained and can have excellent proliferative and mineralization potentials. Therefore, many studies have investigated the isolation and bone forma...

    Authors: Takazumi Yasui, Yo Mabuchi, Satoru Morikawa, Katsuhiro Onizawa, Chihiro Akazawa, Taneaki Nakagawa, Hideyuki Okano and Yumi Matsuzaki
    Citation: Inflammation and Regeneration 2017 37:8
    Content type: Review Published on:

  41. The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...

    Authors: Noriko Sugino, Tatsuo Ichinohe, Akifumi Takaori-Kondo, Taira Maekawa and Yasuo Miura
    Citation: Inflammation and Regeneration 2017 37:7
    Content type: Review Published on:

  44. Oval cells, specific liver progenitors, are activated in response to injury. The human umbilical cord blood (hUCB) is a possible source of transplantable hepatic progenitors and can be used in cases of severe ...

    Authors: Hussein Abdellatif, Gamal Shiha, Dalia M. Saleh, Huda Eltahry and Kamal G. Botros
    Citation: Inflammation and Regeneration 2017 37:5
    Content type: Research article Published on:

  46. Pericytes, surrounding the endothelium, fulfill diverse functions that are crucial for vascular homeostasis. The loss of pericytes is associated with pathologies, such as diabetic retinopathy and Alzheimer’s d...

    Authors: Jan Eglinger, Haiko Karsjens and Eckhard Lammert
    Citation: Inflammation and Regeneration 2017 37:2
    Content type: Research article Published on:

  47. Periventricular leukomalacia (PVL) is a type of multifactorial brain injury that causes cerebral palsy in premature infants. To date, effective therapies for PVL have not been available. In this study, we exam...

    Authors: Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio and Ikuo Morita
    Citation: Inflammation and Regeneration 2017 37:1
    Content type: Research article Published on:

  48. Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against car...

    Authors: Takao Ito and Tatsushi Igaki
    Citation: Inflammation and Regeneration 2016 36:25
    Content type: Review Published on:

  49. This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. MSCs show a unique function to modulate immune reaction although the molecular m...

    Authors: Ryo Tamura, Shinji Uemoto and Yasuhiko Tabata
    Citation: Inflammation and Regeneration 2016 36:26
    Content type: Research article Published on:

  50. Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increa...

    Authors: Seitaro Fujishima
    Citation: Inflammation and Regeneration 2016 36:24
    Content type: Review Published on:


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Inflammation and Regeneration

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