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  1. Interleukin (IL)-34 acts as an alternative ligand for the colony-stimulating factor-1 receptor and controls the biology of myeloid cells, including survival, proliferation, and differentiation. IL-34 has been ...

    Authors: Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi, Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2020 40:25
  2. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in Wuhan, China, and has spread globally to most countries. In Japan, the first COVID-...

    Authors: Tokio Hoshina, Hiroka Aonuma, Manabu Ote, Tatsuya Sakurai, Erisha Saiki, Yuki Kinjo, Kazuhiro Kondo, Masataka Okabe and Hirotaka Kanuka
    Citation: Inflammation and Regeneration 2020 40:38
  3. In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world d...

    Authors: Misato Hashizume
    Citation: Inflammation and Regeneration 2020 40:24
  4. The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some...

    Authors: Shintaro Hojyo, Mona Uchida, Kumiko Tanaka, Rie Hasebe, Yuki Tanaka, Masaaki Murakami and Toshio Hirano
    Citation: Inflammation and Regeneration 2020 40:37
  5. Hair follicle (HF) formation and growth are sustained by epithelial-mesenchymal interaction via growth factors and cytokines. Pivotal roles of FGFs on HF regeneration and neogenesis have been reported mainly i...

    Authors: Misaki Kinoshita-Ise, Aki Tsukashima, Tomonari Kinoshita, Yoshimi Yamazaki and Manabu Ohyama
    Citation: Inflammation and Regeneration 2020 40:35
  6. In bone tissues, metabolic turnover through bone resorption by osteoclasts and bone formation by osteoblasts, termed bone remodeling, is strictly controlled and maintains homeostasis. Fibrinolytic factors are ...

    Authors: Kiyotaka Okada, Minoru Nishioka and Hiroshi Kaji
    Citation: Inflammation and Regeneration 2020 40:22
  7. The COVID-19 pandemic highlighted the vulnerability of every aspect of the globalized world, including R&D. Potentially critical R&D areas have been neglected because of the lack of market-driven incentives. H...

    Authors: Hiroki Nakatani, Kei Katsuno and Hayato Urabe
    Citation: Inflammation and Regeneration 2020 40:34
  8. Due to the nature of enhanced resistance to conventional chemo/radiotherapies and metastasis, highly tumorigenic cancer stem cells (CSCs) have been proposed as a promising target for cancer eradication. To tac...

    Authors: Tetsuya Taga and Kouichi Tabu
    Citation: Inflammation and Regeneration 2020 40:33
  9. It has been reported that coronavirus disease 2019 (COVID-19) causes not only pneumonia but also systemic inflammations including central nervous system (CNS) disorders. However, little is known about the mech...

    Authors: Yoshitaka Kase and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:32
  10. Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinica...

    Authors: Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2020 40:20
  11. Analysis of various genetically modified mice, with supernumerary teeth, has revealed the following two intrinsic molecular mechanisms that increase the number of teeth. One plausible explanation for supernume...

    Authors: Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata and Kazuhisa Bessho
    Citation: Inflammation and Regeneration 2020 40:21
  12. Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative ...

    Authors: So Nakagawa and Takayuki Miyazawa
    Citation: Inflammation and Regeneration 2020 40:17

    The Correction to this article has been published in Inflammation and Regeneration 2020 40:41

  13. An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating pandemic. As we have not developed curative medicine and effective vaccine, the end of this life-threatening infectious disease is...

    Authors: Ryo Otsuka and Ken-ichiro Seino
    Citation: Inflammation and Regeneration 2020 40:19
  14. Dormant chemotherapy-resistant leukemia cells can survive for an extended period before relapse. Nevertheless, the mechanisms underlying the development of chemoresistance in vivo remain unclear.

    Authors: Maho Morimatsu, Erika Yamashita, Shigeto Seno, Takao Sudo, Junichi Kikuta, Hiroki Mizuno, Daisuke Okuzaki, Daisuke Motooka and Masaru Ishii
    Citation: Inflammation and Regeneration 2020 40:15
  15. The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and the ensuing worldwide pandemic. The spread of the virus has ...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takahiro Iwasawa, Masaru Kumagai, Takeki Sato, Satoko Motegi, Yui Ishii, Youhei Koseki, Kei Tomiyoshi, Kazuki Natsui, Nobutaka Takeda, Yuki Yoshida, Fusako Yamazaki, Yuichi Kojima, Yusuke Watanabe, Naruhiro Kimura…
    Citation: Inflammation and Regeneration 2020 40:14
  16. Adult neurogenesis occurs throughout life in restricted brain regions in mammals. However, the number of neural stem cells (NSCs) that generate new neurons steadily decreases with age, resulting in a decrease ...

    Authors: Yoshitaka Kase, Takuya Shimazaki and Hideyuki Okano
    Citation: Inflammation and Regeneration 2020 40:10
  17. Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs...

    Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada and Teruhisa Kawamura
    Citation: Inflammation and Regeneration 2020 40:8
  18. Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions i...

    Authors: Naoki Hosen
    Citation: Inflammation and Regeneration 2020 40:4
  19. Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because abnormalities in RANKL, its signalin...

    Authors: Takehito Ono, Mikihito Hayashi, Fumiyuki Sasaki and Tomoki Nakashima
    Citation: Inflammation and Regeneration 2020 40:2
  20. Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...

    Authors: Yoshikazu Kishino, Jun Fujita, Shugo Tohyama, Marina Okada, Sho Tanosaki, Shota Someya and Keiichi Fukuda
    Citation: Inflammation and Regeneration 2020 40:1
  21. Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has f...

    Authors: Yutaka Kuroda, Toshiyuki Kawai, Koji Goto and Shuichi Matsuda
    Citation: Inflammation and Regeneration 2019 39:20
  22. Mesenchymal stem cells (MSCs) can be cultured relatively easily and can be obtained not only from the bone marrow, but also from medical waste such as adipose tissue and umbilical cord tissue. Because of its l...

    Authors: Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Tomoaki Yoshida, Shunsuke Nojiri, Masahiro Ogawa and Shuji Terai
    Citation: Inflammation and Regeneration 2019 39:18
  23. Induced pluripotent stem cells (iPSCs) can be produced from various somatic cells and have the ability to differentiate into various cells and tissues of the body. Regenerative medicine using iPSCs is expected...

    Authors: Masafumi Umekage, Yoshiko Sato and Naoko Takasu
    Citation: Inflammation and Regeneration 2019 39:17
  24. Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential a...

    Authors: Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito and Takahiro Ochiya
    Citation: Inflammation and Regeneration 2019 39:13
  25. Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 fam...

    Authors: Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa and Junya Masumoto
    Citation: Inflammation and Regeneration 2019 39:12
  26. Chimeric antigen receptor (CAR) T cell therapy is a new cancer immunotherapy targeting cancer-specific cell surface antigen. CD19-CAR T cells have been already shown to be very effective to B cell leukemia/lym...

    Authors: Kana Hasegawa and Naoki Hosen
    Citation: Inflammation and Regeneration 2019 39:10
  27. During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell...

    Authors: Tomohiro Iba, Hisamichi Naito, Shota Shimizu, Fitriana Nur Rahmawati, Taku Wakabayashi and Nobuyuki Takakura
    Citation: Inflammation and Regeneration 2019 39:9
  28. Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, ...

    Authors: Koichiro Watanabe, Yasuaki Ikuno, Yumi Kakeya, Shinsuke Ikeno, Hitomi Taniura, Masayoshi Kurono, Keito Minemori, Yu Katsuyama and Hayato Naka-Kaneda
    Citation: Inflammation and Regeneration 2019 39:8
  29. TGF-β has an important role in the process of wound healing and scar formation. The aim of this study is to determine the effects of ethanolic and methanolic extracts of Calendula officinalis on the expression of...

    Authors: Maryam Hormozi, Mohammadreza Gholami, Ayda Babaniazi and Anneh Mohammad Gharravi
    Citation: Inflammation and Regeneration 2019 39:7
  30. T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are compos...

    Authors: Ryunosuke Muro, Hiroshi Takayanagi and Takeshi Nitta
    Citation: Inflammation and Regeneration 2019 39:6
  31. Tumor necrosis factor inhibitor therapy for rheumatoid arthritis (RA) patients reduces disease activity, but little is known about the factors that correlate with continuation of remission. To identify demogra...

    Authors: Noriko Kimura, Katsuya Suzuki and Tsutomu Takeuchi
    Citation: Inflammation and Regeneration 2019 39:5


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