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  1. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of the infected individuals have asymp...

    Authors: Taisho Yamada and Akinori Takaoka
    Citation: Inflammation and Regeneration 2023 43:7
  2. Wound healing depends largely on the remodeling of the extracellular matrix around and reorganization of tissue-resident cells. Matrix remodeling associated 7 (MXRA7) is a member of the matrix remodeling-assoc...

    Authors: Ying Shen, Jinling Ning, Lu Zhao, Wei Liu, Ting Wang, Jie Yu and Yiqiang Wang
    Citation: Inflammation and Regeneration 2023 43:5
  3. The coronavirus disease 2019 (COVID-19) pandemic is ongoing because of the repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, highlighting the importance of developing...

    Authors: Ryutaro Kotaki, Saya Moriyama and Yoshimasa Takahashi
    Citation: Inflammation and Regeneration 2023 43:4
  4. Blood coagulation factor XIII (FXIII) promotes cross-linking between fibrin molecules at the final stage of the blood coagulation cascade. However, its expression in cells or tissues and function, particularly...

    Authors: Hirofumi Watanabe, Sho Mokuda, Tadahiro Tokunaga, Hiroki Kohno, Michinori Ishitoku, Kei Araki, Tomohiro Sugimoto, Yusuke Yoshida, Toshihiro Yamamoto, Mayuko Matsumoto, Junya Masumoto, Shintaro Hirata and Eiji Sugiyama
    Citation: Inflammation and Regeneration 2023 43:2
  5. Subarachnoid hemorrhage (SAH) is a fatal disease, with early brain injury (EBI) occurring within 72 h of SAH injury contributes to its poor prognosis. EBI is a complicated phenomenon involving multiple mechani...

    Authors: Hiroki Yamada, Yoshitaka Kase, Yuji Okano, Doyoon Kim, Maraku Goto, Satoshi Takahashi, Hideyuki Okano and Masahiro Toda
    Citation: Inflammation and Regeneration 2022 42:61
  6. To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are preferred to ones using animal cells, because organ functions ca...

    Authors: Sayaka Deguchi and Kazuo Takayama
    Citation: Inflammation and Regeneration 2022 42:62
  7. The high transmissibility and rapid global spread of SARS-CoV-2 since 2019 has led to a huge burden on healthcare worldwide. Anti-SARS-CoV-2 neutralizing antibodies play an important role in not only protectin...

    Authors: Yafei Liu and Hisashi Arase
    Citation: Inflammation and Regeneration 2022 42:58
  8. The molecular platforms of the innate immune system are essential to recognize pathologic external factors that are crucial to differentiate these danger signals from host motifs. A set of sensors recognizing ...

    Authors: Atsushi Kawakami, Yushiro Endo, Tomohiro Koga, Koh-ichiro Yoshiura and Kiyoshi Migita
    Citation: Inflammation and Regeneration 2022 42:37

    The Correction to this article has been published in Inflammation and Regeneration 2022 42:64

  9. Brachial plexus avulsion (BPA) physically involves the detachment of spinal nerve roots themselves and the associated spinal cord segment, leading to permanent paralysis of motor function of the upper limb. Ro...

    Authors: Yanfeng Huang, Xie Zhang, Qionghui Huang, Yaoxing Dou, Chang Qu, Qingqing Xu, Qiuju Yuan, Yan-Fang Xian and Zhi-Xiu Lin
    Citation: Inflammation and Regeneration 2022 42:56
  10. Recent advances in our understanding in the immune-mediated inflammatory diseases (IMID) are explored and promoted by the targeted treatment. Among these targets, cytokines and cytokine receptors have become t...

    Authors: Tsutomu Takeuchi
    Citation: Inflammation and Regeneration 2022 42:35

    The Correction to this article has been published in Inflammation and Regeneration 2022 42:63

  11. Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease characterized by the irreversible destruction of insulin-producing β-cells in pancreatic islets. Helper and cytotoxic T-cells and cytokine producti...

    Authors: Basak Isildar, Serbay Ozkan, Merve Ercin, Selda Gezginci-Oktayoglu, Mahmut Oncul and Meral Koyuturk
    Citation: Inflammation and Regeneration 2022 42:55
  12. The coronavirus disease 2019 (COVID-19) pandemic is widespread; however, accurate predictors of refractory cases have not yet been established. Circulating extracellular vesicles, involved in many pathological...

    Authors: Takahiro Kawasaki, Yoshito Takeda, Ryuya Edahiro, Yuya Shirai, Mari Nogami-Itoh, Takanori Matsuki, Hiroshi Kida, Takatoshi Enomoto, Reina Hara, Yoshimi Noda, Yuichi Adachi, Takayuki Niitsu, Saori Amiya, Yuta Yamaguchi, Teruaki Murakami, Yasuhiro Kato…
    Citation: Inflammation and Regeneration 2022 42:53
  13. Different factors may lead to hepatitis. Among which are liver inflammation and poisoning. We chose two hepatitis models, typical for these two underlying causes. Thus, we aimed to characterize the role of pro...

    Authors: Gal Reches, Netta R. Blondheim Shraga, Florent Carrette, Assaf Malka, Natalia Saleev, Yehuda Gubbay, Offir Ertracht, Izhak Haviv, Linda M. Bradley, Fred Levine and Ron Piran
    Citation: Inflammation and Regeneration 2022 42:52
  14. As an important part of adaptive immunity, T cells are indispensable in the defense against pathogens including viruses. SARS-CoV-2 is a new human coronavirus that occurred at the end of 2019 and has caused th...

    Authors: Xiuyuan Lu and Sho Yamasaki
    Citation: Inflammation and Regeneration 2022 42:51
  15. Coronaviruses regularly cause outbreaks of zoonotic diseases characterized by severe pneumonia. The new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the global pandemic...

    Authors: Shin-ichiro Fujii, Satoru Yamasaki, Tomonori Iyoda and Kanako Shimizu
    Citation: Inflammation and Regeneration 2022 42:50
  16. The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We pr...

    Authors: Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano…
    Citation: Inflammation and Regeneration 2022 42:49
  17. The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that prevents systemic autoimmune diseases and inhibits inflammation by encount...

    Authors: Yosuke Harada, Kentaro Miyamoto, Akihiko Chida, Anna Tojo Okuzawa, Yusuke Yoshimatsu, Yumi Kudo and Tomohisa Sujino
    Citation: Inflammation and Regeneration 2022 42:47
  18. Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the r...

    Authors: Kaoru Yamagata, Shingo Nakayamada, Tong Zhang, Anh Phuong Nguyen, Naoaki Ohkubo, Shigeru Iwata, Shigeaki Kato and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2022 42:46

    The Correction to this article has been published in Inflammation and Regeneration 2022 42:57

  19. The microenvironment of the thymus is composed of a group of stromal cells that include endoderm-derived thymic epithelial cells (TECs) and mesenchymal stromal cells such as fibroblasts and serves as a site fo...

    Authors: Takeshi Nitta
    Citation: Inflammation and Regeneration 2022 42:33
  20. Multiple sclerosis (MS) is a progressive autoimmune demyelinating disease of the central nervous system. To date, there is no effective therapy for it. Our study aimed to determine the potential role of platel...

    Authors: Mariam F. Farid, Yara S. Abouelela, Noha A. E. Yasin, Mohamed R. Mousa, Marwa A. Ibrahim, Abdelbary Prince and Hamdy Rizk
    Citation: Inflammation and Regeneration 2022 42:45
  21. Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable ...

    Authors: Khatereh Khorsandi, Reza Hosseinzadeh, HomaSadat Esfahani, Kavosh Zandsalimi, Fedora Khatibi Shahidi and Heidi Abrahamse
    Citation: Inflammation and Regeneration 2022 42:40
  22. Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and the most common form of dementia. Characterized by the loss of learning, memory, problem-solving, language, and other thinking abilit...

    Authors: Chongyun Wu, Luoman Yang, Shu Feng, Ling Zhu, Luodan Yang, Timon Cheng-Yi Liu and Rui Duan
    Citation: Inflammation and Regeneration 2022 42:31
  23. Rapidly expanding clones (RECs) are one of the single-cell-derived mesenchymal stem cell clones sorted from human bone marrow mononuclear cells (BMMCs), which possess advantageous features. The RECs exhibit lo...

    Authors: Takashi Suyama, Yuto Takemoto, Hiromi Miyauchi, Yuko Kato, Yumi Matsuzaki and Ryuji Kato
    Citation: Inflammation and Regeneration 2022 42:30
  24. Inflammatory response is an important characteristic affecting prognosis and therapeutic response in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory response are still under exp...

    Authors: Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong and Jiade J. Lu
    Citation: Inflammation and Regeneration 2022 42:29
  25. Fibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been widely regarded as the main barrier to axonal regeneration resulting in p...

    Authors: Fei Yao, Yang Luo, Yan-Chang Liu, Yi-Hao Chen, Yi-Teng Li, Xu-Yang Hu, Xing-Yu You, Shui-Sheng Yu, Zi-Yu Li, Lei Chen, Da-Sheng Tian, Mei-Ge Zheng, Li Cheng and Jue-Hua Jing
    Citation: Inflammation and Regeneration 2022 42:44
  26. Highly regulated gene expression program underlies osteogenesis of mesenchymal stem cells (MSCs), but the regulators in the program are not entirely identified. As enhancer RNAs (eRNAs) have recently emerged a...

    Authors: Anh Phuong Nguyen, Kaoru Yamagata, Shigeru Iwata, Gulzhan Trimova, Tong Zhang, Yu Shan, Mai-Phuong Nguyen, Koshiro Sonomoto, Shingo Nakayamada, Shigeaki Kato and Yoshiya Tanaka
    Citation: Inflammation and Regeneration 2022 42:43
  27. Helicobacter pylori (HP) is a Gram-negative bacterium that colonizes the human stomach chronically. Colonization of HP in the gastric mucosa not only causes gastrointestinal diseases, but also is associated with ...

    Authors: Ah-Mee Park and Ikuo Tsunoda
    Citation: Inflammation and Regeneration 2022 42:39
  28. During metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which is abundant in the tumor microenvironment, and acquire invasive and me...

    Authors: Miho Kobayashi, Kashio Fujiwara, Kazuki Takahashi, Yusuke Yoshioka, Takahiro Ochiya, Katarzyna A. Podyma-Inoue and Tetsuro Watabe
    Citation: Inflammation and Regeneration 2022 42:38
  29. Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasi...

    Authors: Masayuki Tsukasaki and Hiroshi Takayanagi
    Citation: Inflammation and Regeneration 2022 42:27
  30. NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extrace...

    Authors: Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin…
    Citation: Inflammation and Regeneration 2022 42:25
  31. Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP...

    Authors: Yang Mu, Tai-lang Yin, Yan Zhang, Jing Yang and Yan-ting Wu
    Citation: Inflammation and Regeneration 2022 42:24


The official journal of the Japanese Society of Inflammation and Regeneration.

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